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• W2094677489 abstract "Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates (NDPs) to deoxynucleoside diphosphates (dNDPs). This RNR is composed of two homodimeric subunits: R1 and R2. R1 binds the NDPs in the active site, and R2 harbors the essential di-iron tyrosyl radical (Y*) cofactor. In this paper, we used PELDOR, a method that detects weak electron-electron dipolar coupling, to make the first direct measurement of the distance between the two Y*'s on each monomer of R2. In the crystal structure of R2, the Y*'s are reduced to tyrosines, and consequently R2 is inactive. In R2, where the Y*'s assume a well-defined geometry with respect to the protein backbone, the PELDOR method allows measurement of a distance of 33.1 +/- 0.2 A that compares favorably to the distance (32.4 A) between the center of mass of the spin density distribution of each Y* on each R2 monomer from the structure. The experiments provide the first direct experimental evidence for two Y*'s in a single R2 in solution." @default.
• W2094677489 created "2016-06-24" @default.
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• W2094677489 date "2003-11-12" @default.
• W2094677489 modified "2023-10-14" @default.
• W2094677489 title "Pulsed ELDOR Spectroscopy Measures the Distance between the Two Tyrosyl Radicals in the R2 Subunit of the <i>E. coli</i> Ribonucleotide Reductase" @default.
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• W2094677489 doi "https://doi.org/10.1021/ja0362095" @default.
• W2094677489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14653724" @default.
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