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• W2094692279 abstract "Neutropenia can often be corrected by treatment with granulocyte-colony stimulating factor (G-CSF) and off-label use of commercial human G-CSF (HuG-CSF) is a commonly used treatment for neutropenic animals. However, long-term HuG-CSF treatment can be associated with adverse effects, including neutropenia. Here, feline (Fe) G-CSF was produced in Pichia pastoris , pegylated (Peg) FeG-CSF and tested in cats. A randomized controlled clinical trial was conducted to evaluate the efficacy of PegFeG-CSF compared to FeG-CSF or HuG-CSF in FIV-infected ( n = 14), FIV-uninfected healthy cats ( n = 19), and in HuG-CSF-induced neutropenic cats ( n = 4). Daily FeG-CSF doses induced higher neutrophil production than HuG-CSF after the second week of treatment ( P ⩽ 0.002). Weekly doses of PegFeG-CSF induced higher neutrophil counts and showed greater sustained activity than weekly doses of FeG-CSF. PegFeG-CSF provided the most therapeutic and sustainable neutrophil production ( P < 0.001) in both FIV-uninfected and FIV-infected cats, without the development of neutralizing antibodies . Conversely, all HuG-CSF-treated cats developed neutralizing antibodies, suggesting cross-reactive antibodies to endogenous G-CSF in a majority of the cases with severe neutropenia. Strikingly, when PegFeG-CSF was used to rescue cats with HuG-CSF-induced neutropenia, clinically normal neutrophil numbers returned. Thus, PegFeG-CSF appears to be a superior treatment for neutropenia in feline patients." @default.
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• W2094692279 date "2014-04-01" @default.
• W2094692279 modified "2023-10-16" @default.
• W2094692279 title "Pegylated feline granulocyte colony-stimulating factor increases neutrophil levels in cats" @default.
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• W2094692279 doi "https://doi.org/10.1016/j.tvjl.2014.01.019" @default.
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