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- W2094697910 abstract "Platelet (plt) and vascular prostaglandins are important regulators of normal hemostasis. Plts produce endoperoxides and thromboxanes which are proaggregatory and prothrombotic, whereas vessels produce PGI2 which is antiaggregatory and antithrombotic. Since the IDM has an increased predisposition to thrombosis, we evaluated arachidonic acid (AA) metabolism and PGI2 production in the umbilical vessels of 12 control infants and 9 IDM of similar gestational age. Mean uptake of 14CAA into vascular tissue of controls and IDM were similar at 9157 ± 1096 (1SE) and 12036 ± 1691 cpm per 30 mgm vascular tissue resp. Thrombin stimulated release of 14CAA was similar in the controls (5.0 ± 0.7) when compared to IDM (5.5 ± 1.3). However in the IDM, the production of vascular 6-Keto-PGF1α (the stable end product of PGI2) was decreased (p<0.02). Controls incorporated 5003 ± 533 cpm (5.2 ± 0.4%) into 6-Keto-PGF1α when compared to 3033 ± 490 cpm (3.2 ± 0.6%) in the IDM. A significant inverse correlation (r=0.87; p<0.02) was observed between maternal HbA1c levels and the conversion of AA to 6-Keto-PGF1α in the IDM. Rigorous control of maternal diabetes appears to be the best prophylaxis against the decrease in PGI2 in the IDM. We have previously shown that plt. endoperoxides are increased in the IDM. Thus, the normal balance between proaggregatory (plt) and antiaggregatory (vascular) prostaglandins is disrupted in the IDM, a factor which favors thrombosis." @default.
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- W2094697910 date "1981-04-01" @default.
- W2094697910 modified "2023-09-26" @default.
- W2094697910 title "882 DECREASED PROSTACYCLIN OR PGI2 PRODUCTION IN THE INFANT OF THE DIABETIC MOTHER (IDM). CORRELATION WITH MATERNAL HbA1c" @default.
- W2094697910 doi "https://doi.org/10.1203/00006450-198104001-00907" @default.
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