FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094701432> ?p ?o ?g. }

• W2094701432 endingPage "1069" @default.
• W2094701432 startingPage "1060" @default.
• W2094701432 abstract "Background The ABCD2 score improves stratification of patients with transient ischaemic attack by early stroke risk. We aimed to develop two new versions of the score: one that was based on preclinical information and one that was based on imaging and other secondary care assessments. Methods We analysed pooled data from patients with clinically defined transient ischaemic attack who were investigated while in secondary care. Items that contribute to the ABCD2 score (age, blood pressure, clinical weakness, duration, and diabetes), other clinical variables, carotid stenosis, and abnormal acute diffusion-weighted imaging (DWI) were recorded and were included in multivariate logistic regression analysis of stroke occurrence at early time intervals after onset of transient ischaemic attack. Scores based on the findings of this analysis were validated in patients with transient ischaemic attack from two independent population-based cohorts. Findings 3886 patients were included in the study: 2654 in the derivation sample and 1232 in the validation sample. We derived the ABCD3 score (range 0–9 points) by assigning 2 points for dual transient ischaemic attack (an earlier transient ischaemic attack within 7 days of the index event). C statistics (which indicate discrimination better than chance at >0·5) for the ABCD3 score were 0·78 at 2 days, 0·80 at 7 days, 0·79 at 28 days, and 0·77 at 90 days, compared with C statistics for the ABCD2 score of 0·71 at 2 days (p=0·083), 0·71 at 7 days (p=0·012), 0·71 at 28 days (p=0·021), and 0·69 at 90 days (p=0·018). We included stenosis of at least 50% on carotid imaging (2 points) and abnormal DWI (2 points) in the ABCD3-imaging (ABCD3-I) score (0–13 points). C statistics for the ABCD3-I score were 0·90 at 2 days (compared with ABCD2 score p=0·035), 0·92 at 7 days (p=0·001), 0·85 at 28 days (p=0·028), and 0·79 at 90 days (p=0·073). The 90-day net reclassification improvement compared with ABCD2 was 29·1% for ABCD3 (p=0·0003) and 39·4% for ABCD3-I (p=0·034). In the validation sample, the ABCD3 and ABCD3-I scores predicted early stroke at 7, 28, and 90 days. However, discrimination and net reclassification of patients with early stroke were similar with ABCD3 compared with ABCD2. Interpretation The ABCD3-I score can improve risk stratification after transient ischaemic attack in secondary care settings. However, use of ABCD3 cannot be recommended without further validation. Funding Health Research Board of Ireland, Irish Heart Foundation, and Irish National Lottery. The ABCD2 score improves stratification of patients with transient ischaemic attack by early stroke risk. We aimed to develop two new versions of the score: one that was based on preclinical information and one that was based on imaging and other secondary care assessments. We analysed pooled data from patients with clinically defined transient ischaemic attack who were investigated while in secondary care. Items that contribute to the ABCD2 score (age, blood pressure, clinical weakness, duration, and diabetes), other clinical variables, carotid stenosis, and abnormal acute diffusion-weighted imaging (DWI) were recorded and were included in multivariate logistic regression analysis of stroke occurrence at early time intervals after onset of transient ischaemic attack. Scores based on the findings of this analysis were validated in patients with transient ischaemic attack from two independent population-based cohorts. 3886 patients were included in the study: 2654 in the derivation sample and 1232 in the validation sample. We derived the ABCD3 score (range 0–9 points) by assigning 2 points for dual transient ischaemic attack (an earlier transient ischaemic attack within 7 days of the index event). C statistics (which indicate discrimination better than chance at >0·5) for the ABCD3 score were 0·78 at 2 days, 0·80 at 7 days, 0·79 at 28 days, and 0·77 at 90 days, compared with C statistics for the ABCD2 score of 0·71 at 2 days (p=0·083), 0·71 at 7 days (p=0·012), 0·71 at 28 days (p=0·021), and 0·69 at 90 days (p=0·018). We included stenosis of at least 50% on carotid imaging (2 points) and abnormal DWI (2 points) in the ABCD3-imaging (ABCD3-I) score (0–13 points). C statistics for the ABCD3-I score were 0·90 at 2 days (compared with ABCD2 score p=0·035), 0·92 at 7 days (p=0·001), 0·85 at 28 days (p=0·028), and 0·79 at 90 days (p=0·073). The 90-day net reclassification improvement compared with ABCD2 was 29·1% for ABCD3 (p=0·0003) and 39·4% for ABCD3-I (p=0·034). In the validation sample, the ABCD3 and ABCD3-I scores predicted early stroke at 7, 28, and 90 days. However, discrimination and net reclassification of patients with early stroke were similar with ABCD3 compared with ABCD2. The ABCD3-I score can improve risk stratification after transient ischaemic attack in secondary care settings. However, use of ABCD3 cannot be recommended without further validation." @default.
• W2094701432 created "2016-06-24" @default.
• W2094701432 creator A5004230927 @default.
• W2094701432 creator A5004980235 @default.
• W2094701432 creator A5009588075 @default.
• W2094701432 creator A5013990412 @default.
• W2094701432 creator A5018531683 @default.
• W2094701432 creator A5018651754 @default.
• W2094701432 creator A5020373936 @default.
• W2094701432 creator A5023091399 @default.
• W2094701432 creator A5026157924 @default.
• W2094701432 creator A5027926967 @default.
• W2094701432 creator A5030528983 @default.
• W2094701432 creator A5033574822 @default.
• W2094701432 creator A5051252423 @default.
• W2094701432 creator A5051280520 @default.
• W2094701432 creator A5055469105 @default.
• W2094701432 creator A5068362864 @default.
• W2094701432 creator A5069080787 @default.
• W2094701432 creator A5075359983 @default.
• W2094701432 creator A5079863121 @default.
• W2094701432 creator A5087721576 @default.
• W2094701432 creator A5088863284 @default.
• W2094701432 creator A5091213325 @default.
• W2094701432 date "2010-11-01" @default.
• W2094701432 modified "2023-10-10" @default.
• W2094701432 title "Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study" @default.
• W2094701432 cites W1968789965 @default.
• W2094701432 cites W1977815164 @default.
• W2094701432 cites W1978446763 @default.
• W2094701432 cites W1983241227 @default.
• W2094701432 cites W2016997057 @default.
• W2094701432 cites W2018152980 @default.
• W2094701432 cites W2021949514 @default.
• W2094701432 cites W2024433903 @default.
• W2094701432 cites W2051036958 @default.
• W2094701432 cites W2051411536 @default.
• W2094701432 cites W2059985067 @default.
• W2094701432 cites W2071044146 @default.
• W2094701432 cites W2077005391 @default.
• W2094701432 cites W2078063083 @default.
• W2094701432 cites W2084959658 @default.
• W2094701432 cites W2086098494 @default.
• W2094701432 cites W2096428391 @default.
• W2094701432 cites W2096807144 @default.
• W2094701432 cites W2099777808 @default.
• W2094701432 cites W2101530807 @default.
• W2094701432 cites W2110077551 @default.
• W2094701432 cites W2111089169 @default.
• W2094701432 cites W2112316706 @default.
• W2094701432 cites W2116677542 @default.
• W2094701432 cites W2118663843 @default.
• W2094701432 cites W2120088424 @default.
• W2094701432 cites W2120531185 @default.
• W2094701432 cites W2128298992 @default.
• W2094701432 cites W2130234815 @default.
• W2094701432 cites W2148919757 @default.
• W2094701432 cites W2150724158 @default.
• W2094701432 cites W2152924629 @default.
• W2094701432 cites W2155947014 @default.
• W2094701432 cites W2158379591 @default.
• W2094701432 cites W2163691192 @default.
• W2094701432 cites W2165920141 @default.
• W2094701432 cites W2170765765 @default.
• W2094701432 cites W2767911074 @default.
• W2094701432 doi "https://doi.org/10.1016/s1474-4422(10)70240-4" @default.
• W2094701432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20934388" @default.
• W2094701432 hasPublicationYear "2010" @default.
• W2094701432 type Work @default.
• W2094701432 sameAs 2094701432 @default.
• W2094701432 citedByCount "253" @default.
• W2094701432 countsByYear W20947014322012 @default.
• W2094701432 countsByYear W20947014322013 @default.
• W2094701432 countsByYear W20947014322014 @default.
• W2094701432 countsByYear W20947014322015 @default.
• W2094701432 countsByYear W20947014322016 @default.
• W2094701432 countsByYear W20947014322017 @default.
• W2094701432 countsByYear W20947014322018 @default.
• W2094701432 countsByYear W20947014322019 @default.
• W2094701432 countsByYear W20947014322020 @default.
• W2094701432 countsByYear W20947014322021 @default.
• W2094701432 countsByYear W20947014322022 @default.
• W2094701432 countsByYear W20947014322023 @default.
• W2094701432 crossrefType "journal-article" @default.
• W2094701432 hasAuthorship W2094701432A5004230927 @default.
• W2094701432 hasAuthorship W2094701432A5004980235 @default.
• W2094701432 hasAuthorship W2094701432A5009588075 @default.
• W2094701432 hasAuthorship W2094701432A5013990412 @default.
• W2094701432 hasAuthorship W2094701432A5018531683 @default.
• W2094701432 hasAuthorship W2094701432A5018651754 @default.
• W2094701432 hasAuthorship W2094701432A5020373936 @default.
• W2094701432 hasAuthorship W2094701432A5023091399 @default.
• W2094701432 hasAuthorship W2094701432A5026157924 @default.
• W2094701432 hasAuthorship W2094701432A5027926967 @default.
• W2094701432 hasAuthorship W2094701432A5030528983 @default.
• W2094701432 hasAuthorship W2094701432A5033574822 @default.
• W2094701432 hasAuthorship W2094701432A5051252423 @default.
• W2094701432 hasAuthorship W2094701432A5051280520 @default.

• next