FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094703974> ?p ?o ?g. }

• W2094703974 endingPage "6714" @default.
• W2094703974 startingPage "6701" @default.
• W2094703974 abstract "CtBP2, as a transcriptional corepressor of epithelial-specific genes, has been reported to promote tumor due to upregulating epithelial-mesenchymal transition (EMT) in cancer cells. CtBP2 was also demonstrated to contribute to the proliferation of esophageal squamous cell carcinoma (ESCC) cells through a negative transcriptional regulation of p16(INK4A). In this study, for the first time, we reported that CtBP2 expression, along with CCNH/CDK7, was higher in ESCC tissues with lymph node metastases than in those without lymph node metastases. Moreover, both CtBP2 and CCNH/CDK7 were positively correlated with E-cadherin, tumor grade, and tumor metastasis. However, the concrete mechanism of CtBP2's role in enhancing ESCC migration remains incompletely understood. We confirmed that CCNH/CDK7 could directly interact with CtBP2 in ESCC cells in vivo and in vitro. Furthermore, our data demonstrate for the first time that CtBP2 enhanced the migration of ESCC cells in a CCNH/CDK7-dependent manner. Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of ESCC." @default.
• W2094703974 created "2016-06-24" @default.
• W2094703974 creator A5004596969 @default.
• W2094703974 creator A5035181295 @default.
• W2094703974 creator A5047499885 @default.
• W2094703974 creator A5056798927 @default.
• W2094703974 creator A5072492963 @default.
• W2094703974 creator A5086368135 @default.
• W2094703974 creator A5087617944 @default.
• W2094703974 creator A5090818171 @default.
• W2094703974 date "2015-03-29" @default.
• W2094703974 modified "2023-10-18" @default.
• W2094703974 title "Interaction with CCNH/CDK7 facilitates CtBP2 promoting esophageal squamous cell carcinoma (ESCC) metastasis via upregulating epithelial-mesenchymal transition (EMT) progression" @default.
• W2094703974 cites W1040915469 @default.
• W2094703974 cites W1565231771 @default.
• W2094703974 cites W1964093831 @default.
• W2094703974 cites W1977730161 @default.
• W2094703974 cites W1979417455 @default.
• W2094703974 cites W1991739980 @default.
• W2094703974 cites W1996741456 @default.
• W2094703974 cites W2002761920 @default.
• W2094703974 cites W2012572985 @default.
• W2094703974 cites W2035568982 @default.
• W2094703974 cites W2038162228 @default.
• W2094703974 cites W2047283411 @default.
• W2094703974 cites W2047455690 @default.
• W2094703974 cites W2048122656 @default.
• W2094703974 cites W2050775651 @default.
• W2094703974 cites W2061449441 @default.
• W2094703974 cites W2061543344 @default.
• W2094703974 cites W2062111117 @default.
• W2094703974 cites W2067086789 @default.
• W2094703974 cites W2069806246 @default.
• W2094703974 cites W2073320389 @default.
• W2094703974 cites W2076590245 @default.
• W2094703974 cites W2077462602 @default.
• W2094703974 cites W2078958831 @default.
• W2094703974 cites W2084254567 @default.
• W2094703974 cites W2104462121 @default.
• W2094703974 cites W2104584000 @default.
• W2094703974 cites W2106787323 @default.
• W2094703974 cites W2111365962 @default.
• W2094703974 cites W2125443005 @default.
• W2094703974 cites W2137530154 @default.
• W2094703974 cites W2140551998 @default.
• W2094703974 cites W2146678830 @default.
• W2094703974 cites W2172083228 @default.
• W2094703974 cites W2326889571 @default.
• W2094703974 cites W4252560545 @default.
• W2094703974 doi "https://doi.org/10.1007/s13277-015-3354-x" @default.
• W2094703974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25820824" @default.
• W2094703974 hasPublicationYear "2015" @default.
• W2094703974 type Work @default.
• W2094703974 sameAs 2094703974 @default.
• W2094703974 citedByCount "20" @default.
• W2094703974 countsByYear W20947039742016 @default.
• W2094703974 countsByYear W20947039742017 @default.
• W2094703974 countsByYear W20947039742018 @default.
• W2094703974 countsByYear W20947039742019 @default.
• W2094703974 countsByYear W20947039742020 @default.
• W2094703974 countsByYear W20947039742021 @default.
• W2094703974 countsByYear W20947039742022 @default.
• W2094703974 countsByYear W20947039742023 @default.
• W2094703974 crossrefType "journal-article" @default.
• W2094703974 hasAuthorship W2094703974A5004596969 @default.
• W2094703974 hasAuthorship W2094703974A5035181295 @default.
• W2094703974 hasAuthorship W2094703974A5047499885 @default.
• W2094703974 hasAuthorship W2094703974A5056798927 @default.
• W2094703974 hasAuthorship W2094703974A5072492963 @default.
• W2094703974 hasAuthorship W2094703974A5086368135 @default.
• W2094703974 hasAuthorship W2094703974A5087617944 @default.
• W2094703974 hasAuthorship W2094703974A5090818171 @default.
• W2094703974 hasConcept C104317684 @default.
• W2094703974 hasConcept C121608353 @default.
• W2094703974 hasConcept C127561419 @default.
• W2094703974 hasConcept C2779013556 @default.
• W2094703974 hasConcept C502942594 @default.
• W2094703974 hasConcept C54355233 @default.
• W2094703974 hasConcept C76419328 @default.
• W2094703974 hasConcept C86803240 @default.
• W2094703974 hasConceptScore W2094703974C104317684 @default.
• W2094703974 hasConceptScore W2094703974C121608353 @default.
• W2094703974 hasConceptScore W2094703974C127561419 @default.
• W2094703974 hasConceptScore W2094703974C2779013556 @default.
• W2094703974 hasConceptScore W2094703974C502942594 @default.
• W2094703974 hasConceptScore W2094703974C54355233 @default.
• W2094703974 hasConceptScore W2094703974C76419328 @default.
• W2094703974 hasConceptScore W2094703974C86803240 @default.
• W2094703974 hasIssue "9" @default.
• W2094703974 hasLocation W20947039741 @default.
• W2094703974 hasLocation W20947039742 @default.
• W2094703974 hasOpenAccess W2094703974 @default.
• W2094703974 hasPrimaryLocation W20947039741 @default.
• W2094703974 hasRelatedWork W2002597275 @default.
• W2094703974 hasRelatedWork W2176631918 @default.
• W2094703974 hasRelatedWork W2295552376 @default.
• W2094703974 hasRelatedWork W2801632896 @default.
• W2094703974 hasRelatedWork W2988003569 @default.

• next