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- W2094710367 abstract "The interaction of peroxidized cardiolipin with ferrocytochrome c induces two kinetically and chemically distinct processes. The first is a rapid oxidation of ferrocytochrome c, followed by a slower, irreversible disruption of heme c. The oxidation of ferrocytochrome c by peroxidized cardiolipin is explained by a Fenton-type reaction. Heme scission is a consequence of the radical-mediated reactions initiated by the interaction of ferric heme iron with peroxidized cardiolipin. Simultaneously with the heme c disruption, generation of hydroxyl radical is detected by EPR spectroscopy using the spin trapping technique. The resulting apocytochrome c sediments as a heterogeneous mixture of high aggregates, as judged by sedimentation analysis. Both the oxidative process and the destructive process were suppressed by nonionic detergents and/or high ionic strength. The mechanism for generating radicals and heme rupture is presented." @default.
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- W2094710367 date "2012-11-18" @default.
- W2094710367 modified "2023-09-25" @default.
- W2094710367 title "Elucidating the mechanism of ferrocytochrome c heme disruption by peroxidized cardiolipin" @default.
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- W2094710367 doi "https://doi.org/10.1007/s00775-012-0958-0" @default.
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