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- W2094710532 abstract "Hydroxyapatite (HA)-coated metallic prostheses, which combine the osteoconductivity of HA and high strength of metallic alloys, have been increasingly the choice of joint replacement prostheses by surgeons as the general population lives longer. Surface modification of metallic implant surfaces is one of the key focal points to implantation technology. In addition to material chemistry, surface topography has been found to positively impact cellular response and is able to enhance the life time of the implant. Recently, a new technique, template-assisted electrohydrodynamic atomization (TAEA) spraying, developed using the principles of electrohydrodynamic atomization spraying, which is an electrically driven jet-based deposition method, is of considerable interest in surface topography formation. The process offers the attractive advantages of compatibility with micro-fabrication technology and versatility in pattern specification for advanced implant designs. This technology incorporates nanosized calcium phosphate to mimic the size and chemical composition of bone mineral in a micrometer-dimension pattern configuration to guide cellular responses. In vitro studies showed that both pillar and track nano Silicon-substituted HA (SiHA) patterns were able to encourage the attachment and growth of osteoblast cells, the track patterns provided the favourite surface for the initial cell attachment while a fast cell proliferation rate was found on the pillar pattern from day 1 to day 5 in comparison with that of a SiHA-coated surface. The alignment of actin cytoskeleton of osteoblast cells matched the orientation of the entire cell. The shear peel strength of the patterned interlocking nano-HA coating was found to be at least an order of magnitude higher than the conventional HA coating. Therefore, TAEA offers great potential for producing new coatings with a tailored surface topography, on both the micro- and nano-scale in a more cost effective way to enhance the performance of medical implants." @default.
- W2094710532 created "2016-06-24" @default.
- W2094710532 creator A5041736397 @default.
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- W2094710532 date "2012-03-01" @default.
- W2094710532 modified "2023-09-23" @default.
- W2094710532 title "ELECTROHYDRODYNAMIC PROCESSING OF CALCIUM PHOSPHATES: COATING AND PATTERNING FOR MEDICAL IMPLANTS" @default.
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- W2094710532 doi "https://doi.org/10.1142/s1793984411000426" @default.
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