FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094723475> ?p ?o ?g. }

• W2094723475 endingPage "3876" @default.
• W2094723475 startingPage "3866" @default.
• W2094723475 abstract "The X-linked mouse Rhox gene cluster contains more than 30 homeobox genes that are candidates to regulate multiple steps in male and female gametogenesis. The founding member of the Rhox gene cluster, Rhox5, is an androgen-dependent gene expressed in Sertoli cells that promotes the survival and differentiation of the adjacent male germ cells. Here, we report the first identification and characterization of a Rhox5-regulated gene. This gene, Unc5c, encodes a pro-apoptotic receptor with tumor suppressor activity that we found is negatively regulated by Rhox5 in the testis in vivo. Transfection analyses in cell lines of different origin indicated that Rhox5-dependent down-regulation of Unc5c requires another Sertoli cell-specific cofactor. Examination of other mouse Rhox family members revealed that mouse RHOX2 and RHOX3 also have the ability to down-regulate Unc5c expression. The human RHOX protein PEPP2 (RHOXF2) also had this ability, indicating that Unc5c repression is a conserved RHOX-dependent response. Deletion analysis identified a Rhox5-responsive element in the Unc5c 5'-untranslated region. Although 5'-untranslated regions typically house post-transcriptional elements, several lines of evidence indicated that Rhox5 down-regulates Unc5c at the transcriptional level. The repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis, as we found that Unc5c mutant mice have decreased germ cell apoptosis in the testis. Along with our other data, these findings led us to propose a model in which Rhox5 is a negative regulator upstream of Unc5c in a Sertoli-cell pathway that promotes germ-cell survival." @default.
• W2094723475 created "2016-06-24" @default.
• W2094723475 creator A5014757042 @default.
• W2094723475 creator A5023541010 @default.
• W2094723475 creator A5024721800 @default.
• W2094723475 creator A5028641640 @default.
• W2094723475 creator A5030531465 @default.
• W2094723475 date "2008-02-01" @default.
• W2094723475 modified "2023-10-17" @default.
• W2094723475 title "The RHOX5 Homeodomain Protein Mediates Transcriptional Repression of the Netrin-1 Receptor Gene Unc5c" @default.
• W2094723475 cites W126580904 @default.
• W2094723475 cites W1494537911 @default.
• W2094723475 cites W1519055237 @default.
• W2094723475 cites W1788268544 @default.
• W2094723475 cites W1922240536 @default.
• W2094723475 cites W1941286715 @default.
• W2094723475 cites W1964652829 @default.
• W2094723475 cites W1966272997 @default.
• W2094723475 cites W1970749764 @default.
• W2094723475 cites W1972893638 @default.
• W2094723475 cites W1977021493 @default.
• W2094723475 cites W1978797592 @default.
• W2094723475 cites W1984120207 @default.
• W2094723475 cites W1985375719 @default.
• W2094723475 cites W1987654400 @default.
• W2094723475 cites W1987868089 @default.
• W2094723475 cites W1990262503 @default.
• W2094723475 cites W1991591664 @default.
• W2094723475 cites W1993978015 @default.
• W2094723475 cites W1995722234 @default.
• W2094723475 cites W200744680 @default.
• W2094723475 cites W2008597649 @default.
• W2094723475 cites W2010950394 @default.
• W2094723475 cites W2011081704 @default.
• W2094723475 cites W2024646850 @default.
• W2094723475 cites W2026539310 @default.
• W2094723475 cites W2028346256 @default.
• W2094723475 cites W2034728925 @default.
• W2094723475 cites W2037697367 @default.
• W2094723475 cites W2039706200 @default.
• W2094723475 cites W2041547991 @default.
• W2094723475 cites W2042947886 @default.
• W2094723475 cites W2045172642 @default.
• W2094723475 cites W2046477359 @default.
• W2094723475 cites W2049168357 @default.
• W2094723475 cites W2053620687 @default.
• W2094723475 cites W2054267639 @default.
• W2094723475 cites W2055421069 @default.
• W2094723475 cites W2055965454 @default.
• W2094723475 cites W2071522549 @default.
• W2094723475 cites W2072113406 @default.
• W2094723475 cites W2074212982 @default.
• W2094723475 cites W2075086498 @default.
• W2094723475 cites W2075415508 @default.
• W2094723475 cites W2080627177 @default.
• W2094723475 cites W2080651889 @default.
• W2094723475 cites W2082059784 @default.
• W2094723475 cites W2084217794 @default.
• W2094723475 cites W2090295813 @default.
• W2094723475 cites W2094226065 @default.
• W2094723475 cites W2095683952 @default.
• W2094723475 cites W2095925603 @default.
• W2094723475 cites W2096439960 @default.
• W2094723475 cites W2103648398 @default.
• W2094723475 cites W2109840664 @default.
• W2094723475 cites W2109971484 @default.
• W2094723475 cites W2112153902 @default.
• W2094723475 cites W2112985008 @default.
• W2094723475 cites W2113129387 @default.
• W2094723475 cites W2117713674 @default.
• W2094723475 cites W2119888224 @default.
• W2094723475 cites W2121387694 @default.
• W2094723475 cites W2129279490 @default.
• W2094723475 cites W2131918846 @default.
• W2094723475 cites W2145290390 @default.
• W2094723475 cites W2149859911 @default.
• W2094723475 cites W2152000407 @default.
• W2094723475 cites W2166834644 @default.
• W2094723475 doi "https://doi.org/10.1074/jbc.m706717200" @default.
• W2094723475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18077458" @default.
• W2094723475 hasPublicationYear "2008" @default.
• W2094723475 type Work @default.
• W2094723475 sameAs 2094723475 @default.
• W2094723475 citedByCount "28" @default.
• W2094723475 countsByYear W20947234752012 @default.
• W2094723475 countsByYear W20947234752013 @default.
• W2094723475 countsByYear W20947234752014 @default.
• W2094723475 countsByYear W20947234752015 @default.
• W2094723475 countsByYear W20947234752016 @default.
• W2094723475 countsByYear W20947234752021 @default.
• W2094723475 countsByYear W20947234752022 @default.
• W2094723475 crossrefType "journal-article" @default.
• W2094723475 hasAuthorship W2094723475A5014757042 @default.
• W2094723475 hasAuthorship W2094723475A5023541010 @default.
• W2094723475 hasAuthorship W2094723475A5024721800 @default.
• W2094723475 hasAuthorship W2094723475A5028641640 @default.
• W2094723475 hasAuthorship W2094723475A5030531465 @default.
• W2094723475 hasBestOaLocation W20947234751 @default.

• next