Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094732087> ?p ?o ?g. }
- W2094732087 endingPage "56" @default.
- W2094732087 startingPage "51" @default.
- W2094732087 abstract "Azadirachtin is a botanical insecticide that affects various biological processes. The effects of azadirachtin on the digital gene expression profile and growth inhibition in Drosophila larvae have not been investigated. In this study, we applied high-throughput sequencing technology to detect the differentially expressed genes of Drosophila larvae regulated by azadirachtin. A total of 15,322 genes were detected, and 28 genes were found to be significantly regulated by azadirachtin. Biological process and pathway analysis showed that azadirachtin affected starch and sucrose metabolism, defense response, signal transduction, instar larval or pupal development, and chemosensory behavior processes. The genes regulated by azadirachtin were mainly enriched in starch and sucrose metabolism. This study provided a general digital gene expression profile of dysregulated genes in response to azadirachtin and showed that azadirachtin provoked potent growth inhibitory effects in Drosophila larvae by regulating the genes of cuticular protein, amylase, and odorant-binding protein. Finally, we propose a potential mechanism underlying the dysregulation of the insulin/insulin-like growth factor signaling pathway by azadirachtin." @default.
- W2094732087 created "2016-06-24" @default.
- W2094732087 creator A5000234832 @default.
- W2094732087 creator A5006914695 @default.
- W2094732087 creator A5043153389 @default.
- W2094732087 creator A5043372064 @default.
- W2094732087 creator A5090614836 @default.
- W2094732087 date "2014-09-01" @default.
- W2094732087 modified "2023-10-14" @default.
- W2094732087 title "Gene expression profile change and growth inhibition in Drosophila larvae treated with azadirachtin" @default.
- W2094732087 cites W1483949175 @default.
- W2094732087 cites W1552133914 @default.
- W2094732087 cites W1965675775 @default.
- W2094732087 cites W1973420196 @default.
- W2094732087 cites W1977936945 @default.
- W2094732087 cites W1984703686 @default.
- W2094732087 cites W1987377822 @default.
- W2094732087 cites W1987942547 @default.
- W2094732087 cites W1989911454 @default.
- W2094732087 cites W2002403131 @default.
- W2094732087 cites W2004791359 @default.
- W2094732087 cites W2010154023 @default.
- W2094732087 cites W2011867387 @default.
- W2094732087 cites W2012257160 @default.
- W2094732087 cites W2023986253 @default.
- W2094732087 cites W2024381567 @default.
- W2094732087 cites W2025718559 @default.
- W2094732087 cites W2030191622 @default.
- W2094732087 cites W2031653450 @default.
- W2094732087 cites W2032491298 @default.
- W2094732087 cites W2038622947 @default.
- W2094732087 cites W2045210487 @default.
- W2094732087 cites W2048724726 @default.
- W2094732087 cites W2049231048 @default.
- W2094732087 cites W2059000522 @default.
- W2094732087 cites W2079395662 @default.
- W2094732087 cites W2089705979 @default.
- W2094732087 cites W2095666435 @default.
- W2094732087 cites W2097065948 @default.
- W2094732087 cites W2098223459 @default.
- W2094732087 cites W2109120287 @default.
- W2094732087 cites W2114570899 @default.
- W2094732087 cites W2117939265 @default.
- W2094732087 cites W2119356879 @default.
- W2094732087 cites W2124985265 @default.
- W2094732087 cites W2127108219 @default.
- W2094732087 cites W2152239989 @default.
- W2094732087 cites W2154431984 @default.
- W2094732087 cites W2158217645 @default.
- W2094732087 cites W2171641097 @default.
- W2094732087 cites W2177840302 @default.
- W2094732087 cites W2334595206 @default.
- W2094732087 cites W2413904369 @default.
- W2094732087 doi "https://doi.org/10.1016/j.jbiotec.2014.06.014" @default.
- W2094732087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24956222" @default.
- W2094732087 hasPublicationYear "2014" @default.
- W2094732087 type Work @default.
- W2094732087 sameAs 2094732087 @default.
- W2094732087 citedByCount "33" @default.
- W2094732087 countsByYear W20947320872015 @default.
- W2094732087 countsByYear W20947320872016 @default.
- W2094732087 countsByYear W20947320872017 @default.
- W2094732087 countsByYear W20947320872018 @default.
- W2094732087 countsByYear W20947320872019 @default.
- W2094732087 countsByYear W20947320872020 @default.
- W2094732087 countsByYear W20947320872021 @default.
- W2094732087 countsByYear W20947320872022 @default.
- W2094732087 countsByYear W20947320872023 @default.
- W2094732087 crossrefType "journal-article" @default.
- W2094732087 hasAuthorship W2094732087A5000234832 @default.
- W2094732087 hasAuthorship W2094732087A5006914695 @default.
- W2094732087 hasAuthorship W2094732087A5043153389 @default.
- W2094732087 hasAuthorship W2094732087A5043372064 @default.
- W2094732087 hasAuthorship W2094732087A5090614836 @default.
- W2094732087 hasConcept C104317684 @default.
- W2094732087 hasConcept C150194340 @default.
- W2094732087 hasConcept C161176658 @default.
- W2094732087 hasConcept C162317418 @default.
- W2094732087 hasConcept C2779955036 @default.
- W2094732087 hasConcept C55493867 @default.
- W2094732087 hasConcept C6557445 @default.
- W2094732087 hasConcept C86803240 @default.
- W2094732087 hasConceptScore W2094732087C104317684 @default.
- W2094732087 hasConceptScore W2094732087C150194340 @default.
- W2094732087 hasConceptScore W2094732087C161176658 @default.
- W2094732087 hasConceptScore W2094732087C162317418 @default.
- W2094732087 hasConceptScore W2094732087C2779955036 @default.
- W2094732087 hasConceptScore W2094732087C55493867 @default.
- W2094732087 hasConceptScore W2094732087C6557445 @default.
- W2094732087 hasConceptScore W2094732087C86803240 @default.
- W2094732087 hasLocation W20947320871 @default.
- W2094732087 hasLocation W20947320872 @default.
- W2094732087 hasOpenAccess W2094732087 @default.
- W2094732087 hasPrimaryLocation W20947320871 @default.
- W2094732087 hasRelatedWork W1971972549 @default.
- W2094732087 hasRelatedWork W1976510917 @default.
- W2094732087 hasRelatedWork W1995940918 @default.
- W2094732087 hasRelatedWork W2005057264 @default.