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• W2094771204 endingPage "7256" @default.
• W2094771204 startingPage "7251" @default.
• W2094771204 abstract "An antibody generated to an alpha-keto amide containing hapten 1 catalyzes the cis-trans isomerization of peptidyl-prolyl amide bonds in peptides and in the protein RNase T1. The antibody-catalyzed peptide isomerization reaction showed saturation kinetics for the cis-substrate, Suc-Ala-Ala-Pro-Phe-pNA, with a kcat/Km value of 883 s-1.M-1; the reaction was inhibited by the hapten analog 13 (Ki = 3. 0 +/- 0.4 microM). Refolding of denatured RNase T1 to its native conformation also was catalyzed by the antibody, with the antibody-catalyzed folding reaction inhibitable both by the hapten 1 and hapten analog 13. These results demonstrate that antibodies can catalyze conformational changes in protein structure, a transformation involved in many cellular processes." @default.
• W2094771204 created "2016-06-24" @default.
• W2094771204 creator A5012554206 @default.
• W2094771204 creator A5066008654 @default.
• W2094771204 creator A5083547801 @default.
• W2094771204 date "1998-06-23" @default.
• W2094771204 modified "2023-10-13" @default.
• W2094771204 title "Antibody catalysis of peptidyl-prolyl <i>cis-trans</i> isomerization in the folding of RNase T1" @default.
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• W2094771204 doi "https://doi.org/10.1073/pnas.95.13.7251" @default.
• W2094771204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22581" @default.
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