Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094771737> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2094771737 endingPage "3757" @default.
- W2094771737 startingPage "3753" @default.
- W2094771737 abstract "Considering the importance of developing selective COX-2 inhibitors, the present paper explores selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using electrotopological state (E-state) index. The study also shows the utility of E-state index in developing statistically acceptable model having direct physicochemical significance: electron density distribution of different atoms of the oxazolone ring and attached two phenyl rings are important for the selective binding with COX-2 over COX-1. Moreover, the use of indicator variable shows that presence of ortho R(1) substituent (except fluoro) on the N(3)-phenyl ring decreases COX-2 selectivity. Further, an amino substituent at R(2) position (i.e., sulfonamide compound) is favorable for increasing COX-2 selectivity when the R(3) position is unsubstituted." @default.
- W2094771737 created "2016-06-24" @default.
- W2094771737 creator A5076454638 @default.
- W2094771737 creator A5077571004 @default.
- W2094771737 creator A5087029647 @default.
- W2094771737 date "2003-11-01" @default.
- W2094771737 modified "2023-09-24" @default.
- W2094771737 title "Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-Diaryloxazolones using E-State index" @default.
- W2094771737 cites W1572120776 @default.
- W2094771737 cites W180197682 @default.
- W2094771737 cites W1965103420 @default.
- W2094771737 cites W1966186845 @default.
- W2094771737 cites W1999518162 @default.
- W2094771737 cites W2017745795 @default.
- W2094771737 cites W2023703189 @default.
- W2094771737 cites W2048312836 @default.
- W2094771737 cites W2049433363 @default.
- W2094771737 cites W2050437429 @default.
- W2094771737 cites W2114616098 @default.
- W2094771737 cites W2129496997 @default.
- W2094771737 cites W2950196349 @default.
- W2094771737 cites W2951657858 @default.
- W2094771737 cites W84597076 @default.
- W2094771737 doi "https://doi.org/10.1016/j.bmcl.2003.07.002" @default.
- W2094771737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14552773" @default.
- W2094771737 hasPublicationYear "2003" @default.
- W2094771737 type Work @default.
- W2094771737 sameAs 2094771737 @default.
- W2094771737 citedByCount "17" @default.
- W2094771737 countsByYear W20947717372015 @default.
- W2094771737 crossrefType "journal-article" @default.
- W2094771737 hasAuthorship W2094771737A5076454638 @default.
- W2094771737 hasAuthorship W2094771737A5077571004 @default.
- W2094771737 hasAuthorship W2094771737A5087029647 @default.
- W2094771737 hasConcept C118792377 @default.
- W2094771737 hasConcept C161790260 @default.
- W2094771737 hasConcept C178790620 @default.
- W2094771737 hasConcept C185592680 @default.
- W2094771737 hasConcept C2778689049 @default.
- W2094771737 hasConcept C2779790080 @default.
- W2094771737 hasConcept C2780378348 @default.
- W2094771737 hasConcept C71240020 @default.
- W2094771737 hasConceptScore W2094771737C118792377 @default.
- W2094771737 hasConceptScore W2094771737C161790260 @default.
- W2094771737 hasConceptScore W2094771737C178790620 @default.
- W2094771737 hasConceptScore W2094771737C185592680 @default.
- W2094771737 hasConceptScore W2094771737C2778689049 @default.
- W2094771737 hasConceptScore W2094771737C2779790080 @default.
- W2094771737 hasConceptScore W2094771737C2780378348 @default.
- W2094771737 hasConceptScore W2094771737C71240020 @default.
- W2094771737 hasIssue "21" @default.
- W2094771737 hasLocation W20947717371 @default.
- W2094771737 hasLocation W20947717372 @default.
- W2094771737 hasOpenAccess W2094771737 @default.
- W2094771737 hasPrimaryLocation W20947717371 @default.
- W2094771737 hasRelatedWork W2094771737 @default.
- W2094771737 hasRelatedWork W2105666742 @default.
- W2094771737 hasRelatedWork W2120251111 @default.
- W2094771737 hasRelatedWork W2128093567 @default.
- W2094771737 hasRelatedWork W2129735191 @default.
- W2094771737 hasRelatedWork W2186439402 @default.
- W2094771737 hasRelatedWork W2950838670 @default.
- W2094771737 hasRelatedWork W2951185896 @default.
- W2094771737 hasRelatedWork W3007446011 @default.
- W2094771737 hasRelatedWork W3015795223 @default.
- W2094771737 hasVolume "13" @default.
- W2094771737 isParatext "false" @default.
- W2094771737 isRetracted "false" @default.
- W2094771737 magId "2094771737" @default.
- W2094771737 workType "article" @default.