Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094775982> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2094775982 endingPage "407" @default.
- W2094775982 startingPage "405" @default.
- W2094775982 abstract "The recent emergence of variant Creutzfeldt-Jakob disease (vCJD) in the UK, and demonstration that vCJD is caused by the same prion strain that causes bovine spongiform encephalopathy, have led to concerns about the possibility of a human epidemic. Although only 79 cases of vCJD have occurred to date, it is likely that hundreds of thousands of infected cattle entered the human food chain in the late 1980s and early 1990s, and the average incubation period of vCJD is unknown. Mathematical models have not yet been able to give useful predictions of future numbers of cases, and in the absence of a blood test for vCJD, current attempts to reduce uncertainties about future numbers of cases are based on the accumulation of PrPSc in lymphoreticular tissues. Extensive lymphoreticular PrPSc accumulation has been seen in all cases of symptomatic vCJD so far examined, and in one case 8 months prior to the onset of symptoms. Animal models of prion disease suggest that lymphoreticular involvement occurs early in the incubation period and reliably predicts future neurological disease. Based on these data, large scale anonymous studies looking for PrP accumulation in surgically removed tonsillectomy and appendicectomy specimens are underway. Examination of the first 3000 specimens has not revealed any positive samples, but at the moment the significance of negative findings is uncertain. It is anticipated that by the time these studies are complete more data will be available on how early PrP can be demonstrated in lymphoreticular tissue in vCJD, which together with the results from examination of further samples, will allow some comment as to the likelihood of a large human vCJD epidemic." @default.
- W2094775982 created "2016-06-24" @default.
- W2094775982 creator A5049574370 @default.
- W2094775982 date "2000-10-01" @default.
- W2094775982 modified "2023-10-16" @default.
- W2094775982 title "vCJD - predicting the future?" @default.
- W2094775982 cites W1557724928 @default.
- W2094775982 cites W1829344915 @default.
- W2094775982 cites W1964395953 @default.
- W2094775982 cites W1967999280 @default.
- W2094775982 cites W1968485623 @default.
- W2094775982 cites W1975922727 @default.
- W2094775982 cites W2012066076 @default.
- W2094775982 cites W2013696290 @default.
- W2094775982 cites W2047361413 @default.
- W2094775982 cites W2048076949 @default.
- W2094775982 cites W2052672262 @default.
- W2094775982 cites W2061975225 @default.
- W2094775982 cites W2062076246 @default.
- W2094775982 cites W2064722614 @default.
- W2094775982 cites W2082573664 @default.
- W2094775982 cites W2091350553 @default.
- W2094775982 cites W2113193658 @default.
- W2094775982 cites W2135237151 @default.
- W2094775982 cites W2155913624 @default.
- W2094775982 doi "https://doi.org/10.1046/j.1365-2990.2000.00281.x" @default.
- W2094775982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054179" @default.
- W2094775982 hasPublicationYear "2000" @default.
- W2094775982 type Work @default.
- W2094775982 sameAs 2094775982 @default.
- W2094775982 citedByCount "22" @default.
- W2094775982 countsByYear W20947759822014 @default.
- W2094775982 countsByYear W20947759822020 @default.
- W2094775982 crossrefType "journal-article" @default.
- W2094775982 hasAuthorship W2094775982A5049574370 @default.
- W2094775982 hasConcept C142724271 @default.
- W2094775982 hasConcept C143701427 @default.
- W2094775982 hasConcept C25642318 @default.
- W2094775982 hasConcept C2779134260 @default.
- W2094775982 hasConcept C2781131914 @default.
- W2094775982 hasConcept C2910731194 @default.
- W2094775982 hasConcept C3019804061 @default.
- W2094775982 hasConcept C55493867 @default.
- W2094775982 hasConcept C71924100 @default.
- W2094775982 hasConcept C86803240 @default.
- W2094775982 hasConceptScore W2094775982C142724271 @default.
- W2094775982 hasConceptScore W2094775982C143701427 @default.
- W2094775982 hasConceptScore W2094775982C25642318 @default.
- W2094775982 hasConceptScore W2094775982C2779134260 @default.
- W2094775982 hasConceptScore W2094775982C2781131914 @default.
- W2094775982 hasConceptScore W2094775982C2910731194 @default.
- W2094775982 hasConceptScore W2094775982C3019804061 @default.
- W2094775982 hasConceptScore W2094775982C55493867 @default.
- W2094775982 hasConceptScore W2094775982C71924100 @default.
- W2094775982 hasConceptScore W2094775982C86803240 @default.
- W2094775982 hasIssue "5" @default.
- W2094775982 hasLocation W20947759821 @default.
- W2094775982 hasLocation W20947759822 @default.
- W2094775982 hasOpenAccess W2094775982 @default.
- W2094775982 hasPrimaryLocation W20947759821 @default.
- W2094775982 hasRelatedWork W1602785695 @default.
- W2094775982 hasRelatedWork W1964790210 @default.
- W2094775982 hasRelatedWork W2042488383 @default.
- W2094775982 hasRelatedWork W2062076246 @default.
- W2094775982 hasRelatedWork W2067737392 @default.
- W2094775982 hasRelatedWork W2080313251 @default.
- W2094775982 hasRelatedWork W2154511973 @default.
- W2094775982 hasRelatedWork W2185850025 @default.
- W2094775982 hasRelatedWork W2399535365 @default.
- W2094775982 hasRelatedWork W2412499894 @default.
- W2094775982 hasVolume "26" @default.
- W2094775982 isParatext "false" @default.
- W2094775982 isRetracted "false" @default.
- W2094775982 magId "2094775982" @default.
- W2094775982 workType "article" @default.