Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094777384> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2094777384 endingPage "171" @default.
- W2094777384 startingPage "161" @default.
- W2094777384 abstract "Abstract Human fibrinogen, a dimeric structure with a molecular weight of 340,000, is composed of three polypeptide chains: α (A), β (B), and γ, linked by S-S bridges. Following reduction with dithiothreitol and alkylation with tritiated iodoacetic acid, the three chains have been separated on CM-cellulose. Their molecular weights, determined by SDS-polyacrylamide gel electrophoresis were determined to be: α (A) = 64,000; β (B) = 57,000; and γ = 48,000. In preparation for amino acid sequence analysis, each purified chain derivative was cleaved with BrCN, and the fragments chromatographed on Sephadex G-100. Each chain had a characteristic radioactivity and optical density profile. This approach is helpful in isolating the carboxymethylated fragments of each chain. The N-terminal fragment of the α (A) chain, containing 51 amino acid residues, has been isolated and characterized by amino acid analysis, N-terminal analysis, and peptide mapping. Each chain derivative was digested with plasmin. Polyacrylamide gel electrophoresis and titration in the pH stat indicate that the α (A) chain is the preferred substrate for plasmin, a phenomenon previously observed in the intact fibrinogen molecule. This may explain the appearance of a heterogeneous population of α (A) chains upon chromatography of reduced alkylated fibrinogen (from pooled plasma) on CM-cellulose." @default.
- W2094777384 created "2016-06-24" @default.
- W2094777384 creator A5039179394 @default.
- W2094777384 creator A5043765840 @default.
- W2094777384 creator A5086877550 @default.
- W2094777384 date "1972-04-01" @default.
- W2094777384 modified "2023-10-01" @default.
- W2094777384 title "Human fibrinogen: Some characteristics of its S-carboxymethyl derivative chains" @default.
- W2094777384 cites W134566939 @default.
- W2094777384 cites W1528159964 @default.
- W2094777384 cites W1588733323 @default.
- W2094777384 cites W1974808520 @default.
- W2094777384 cites W1977886322 @default.
- W2094777384 cites W1992896821 @default.
- W2094777384 cites W2009732054 @default.
- W2094777384 cites W2029137488 @default.
- W2094777384 cites W2035178202 @default.
- W2094777384 cites W2039845615 @default.
- W2094777384 cites W2057477600 @default.
- W2094777384 cites W2085861396 @default.
- W2094777384 cites W2088282977 @default.
- W2094777384 cites W2093447025 @default.
- W2094777384 cites W2160805842 @default.
- W2094777384 cites W2313048249 @default.
- W2094777384 cites W2342291198 @default.
- W2094777384 doi "https://doi.org/10.1016/0049-3848(72)90048-5" @default.
- W2094777384 hasPublicationYear "1972" @default.
- W2094777384 type Work @default.
- W2094777384 sameAs 2094777384 @default.
- W2094777384 citedByCount "20" @default.
- W2094777384 crossrefType "journal-article" @default.
- W2094777384 hasAuthorship W2094777384A5039179394 @default.
- W2094777384 hasAuthorship W2094777384A5043765840 @default.
- W2094777384 hasAuthorship W2094777384A5086877550 @default.
- W2094777384 hasConcept C101660505 @default.
- W2094777384 hasConcept C116084860 @default.
- W2094777384 hasConcept C181199279 @default.
- W2094777384 hasConcept C185592680 @default.
- W2094777384 hasConcept C193363816 @default.
- W2094777384 hasConcept C2777824588 @default.
- W2094777384 hasConcept C2780197888 @default.
- W2094777384 hasConcept C2781071845 @default.
- W2094777384 hasConcept C43617362 @default.
- W2094777384 hasConcept C50476208 @default.
- W2094777384 hasConcept C515207424 @default.
- W2094777384 hasConcept C55493867 @default.
- W2094777384 hasConcept C58121356 @default.
- W2094777384 hasConceptScore W2094777384C101660505 @default.
- W2094777384 hasConceptScore W2094777384C116084860 @default.
- W2094777384 hasConceptScore W2094777384C181199279 @default.
- W2094777384 hasConceptScore W2094777384C185592680 @default.
- W2094777384 hasConceptScore W2094777384C193363816 @default.
- W2094777384 hasConceptScore W2094777384C2777824588 @default.
- W2094777384 hasConceptScore W2094777384C2780197888 @default.
- W2094777384 hasConceptScore W2094777384C2781071845 @default.
- W2094777384 hasConceptScore W2094777384C43617362 @default.
- W2094777384 hasConceptScore W2094777384C50476208 @default.
- W2094777384 hasConceptScore W2094777384C515207424 @default.
- W2094777384 hasConceptScore W2094777384C55493867 @default.
- W2094777384 hasConceptScore W2094777384C58121356 @default.
- W2094777384 hasIssue "2" @default.
- W2094777384 hasLocation W20947773841 @default.
- W2094777384 hasOpenAccess W2094777384 @default.
- W2094777384 hasPrimaryLocation W20947773841 @default.
- W2094777384 hasRelatedWork W1507628595 @default.
- W2094777384 hasRelatedWork W1529521595 @default.
- W2094777384 hasRelatedWork W1533436380 @default.
- W2094777384 hasRelatedWork W1562590055 @default.
- W2094777384 hasRelatedWork W1605067347 @default.
- W2094777384 hasRelatedWork W1625660792 @default.
- W2094777384 hasRelatedWork W1968034923 @default.
- W2094777384 hasRelatedWork W1992896821 @default.
- W2094777384 hasRelatedWork W2012694860 @default.
- W2094777384 hasRelatedWork W2024558695 @default.
- W2094777384 hasRelatedWork W2029786429 @default.
- W2094777384 hasRelatedWork W2039845615 @default.
- W2094777384 hasRelatedWork W2059723436 @default.
- W2094777384 hasRelatedWork W2075009329 @default.
- W2094777384 hasRelatedWork W2085861396 @default.
- W2094777384 hasRelatedWork W2093147401 @default.
- W2094777384 hasRelatedWork W2093447025 @default.
- W2094777384 hasRelatedWork W2096674223 @default.
- W2094777384 hasRelatedWork W2150131232 @default.
- W2094777384 hasRelatedWork W2160805842 @default.
- W2094777384 hasVolume "1" @default.
- W2094777384 isParatext "false" @default.
- W2094777384 isRetracted "false" @default.
- W2094777384 magId "2094777384" @default.
- W2094777384 workType "article" @default.