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- W2094777788 abstract "Guinea-pig embryo cells were transformed in vitro by the Kirsten strain of mouse sarcoma virus (Ki-MSV). The transformed cells were found to release infectious virus continuously and produced high titers of group-specific, complement-fixing antigen characteristic of the murine leukemia—sarcoma virus complex. Foci of transformed cells were similar in appearance to those obtained with Ki-MSV in mouse and rat cells. The transformed cells produced RNA-dependent DNA polymerase and type-C virus particles with a density of approximately 1.15 g/ml in sucrose gradients by 3H-uridine labelling. The transformed cells from one line produced tumors when transplanted into newborn guinea-pigs. A number of focus-derived clonal lines and “normal cells” derived from infected cells were isolated and characterized. All the focus-derived lines were found to be MSV producers. The Ki-MSV grown in guinea-pig cells replicated efficiently in guineapig and NRK cells but very poorly in mouse cells. A non-cytopathic type-C virus-producing line (clone No. 2) was isolated. A non-focus-forming virus grown in guinea-pig embryo cells (clone No. 2) rescued infectious MSV by direct cocultivation with Ki-MSK non-producer NRK cells. The rescued MSV virus was neutralized by Ki-MSV antiserum and produced foci readily in mouse, rat and guinea-pig cells." @default.
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- W2094777788 date "1973-11-15" @default.
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- W2094777788 title "Characterization of guinea-pig embryo cells transformed by Kirsten mouse sarcoma virus." @default.
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- W2094777788 doi "https://doi.org/10.1002/ijc.2910120307" @default.
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