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• W2094787046 abstract "Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β, which critically regulates the function of this molecule, has remained mysterious for some 30 years following its discovery, the identification of a new cytoplasmic complex of proteins regulating IL-1β activation and secretion has carried our understanding of the role of IL1 in biology and disease one big step further. The inflammasomes, recently identified innate immune complexes that sense intracellular danger- (e.g. uric acid, ATP, cytoplasmic DNA) or pathogen-associated molecular patterns (e.g. muramyl dipeptide, flagellin, anthrax lethal toxin), are now known to be responsible for triggering inflammation in response to several molecular patterns, including, for example, uric acid, a danger-associated molecular pattern and trigger of gout. Dysregulation of inflammasome function is however also the cause of a family of genetic autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS) characterised by recurrent episodes of fever, urticarial-like skin lesions, systemic inflammation and arthritis. In mouse models recapitulating mutations observed in CAPS, neutrophilic inflammation of the skin is a cardinal feature, in a manner similar to several autoinflammatory diseases with skin involvement such as PAPA (pyoderma gangrenosum, acne and pyogenic arthritis) and Schnitzler’s syndrome, in which IL-1β very probably plays a pathogenic role. In this article the role of the inflammasome in IL-1 biology, autoinflammation and disease is reviewed, together with new avenues for the therapy of these diseases. Key words: inflammation; interleukin-1; innate immunity; inflammasome; skin; fever" @default.
• W2094787046 created "2016-06-24" @default.
• W2094787046 creator A5017961900 @default.
• W2094787046 creator A5021314690 @default.
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• W2094787046 date "2012-05-31" @default.
• W2094787046 modified "2023-10-02" @default.
• W2094787046 title "Interleukin-1, inflammasomes, autoinflammation and the skin" @default.
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• W2094787046 cites W1553859547 @default.
• W2094787046 cites W1568477959 @default.
• W2094787046 cites W1590190082 @default.
• W2094787046 cites W1607784912 @default.
• W2094787046 cites W1701460655 @default.
• W2094787046 cites W1963492948 @default.
• W2094787046 cites W1967436988 @default.
• W2094787046 cites W1968057560 @default.
• W2094787046 cites W1972452655 @default.
• W2094787046 cites W1972483153 @default.
• W2094787046 cites W1974079188 @default.
• W2094787046 cites W1976926965 @default.
• W2094787046 cites W1977884267 @default.
• W2094787046 cites W1978462186 @default.
• W2094787046 cites W1985970823 @default.
• W2094787046 cites W1986843662 @default.
• W2094787046 cites W1987287925 @default.
• W2094787046 cites W1990535077 @default.
• W2094787046 cites W1998514739 @default.
• W2094787046 cites W1999276471 @default.
• W2094787046 cites W2005358484 @default.
• W2094787046 cites W2009347072 @default.
• W2094787046 cites W2012270515 @default.
• W2094787046 cites W2018563185 @default.
• W2094787046 cites W2018607502 @default.
• W2094787046 cites W2020954282 @default.
• W2094787046 cites W2028772793 @default.
• W2094787046 cites W2031084334 @default.
• W2094787046 cites W2038636068 @default.
• W2094787046 cites W2042194530 @default.
• W2094787046 cites W2048032544 @default.
• W2094787046 cites W2049652467 @default.
• W2094787046 cites W2050449334 @default.
• W2094787046 cites W2050870561 @default.
• W2094787046 cites W2051384021 @default.
• W2094787046 cites W2063894714 @default.
• W2094787046 cites W2064159268 @default.
• W2094787046 cites W2064512362 @default.
• W2094787046 cites W2065330071 @default.
• W2094787046 cites W2065635384 @default.
• W2094787046 cites W2067374467 @default.
• W2094787046 cites W2087050793 @default.
• W2094787046 cites W2092360953 @default.
• W2094787046 cites W2093329656 @default.
• W2094787046 cites W2093429458 @default.
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• W2094787046 cites W2097714951 @default.
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• W2094787046 cites W2102429140 @default.
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• W2094787046 doi "https://doi.org/10.4414/smw.2012.13590" @default.
• W2094787046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22653747" @default.
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