FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094792326> ?p ?o ?g. }

• W2094792326 endingPage "220" @default.
• W2094792326 startingPage "211" @default.
• W2094792326 abstract "This study evaluated the ‘evoked’ expression of Krox-24 protein in the lumbar spinal cord after peripheral carrageenan-induced inflammation and its modification by preadministration of indomethacin, a non-steroidal anti-inflammatory drug, in freely moving rats. Three h after intraplantar carrageenan (6 mg/150 μl saline) a maximal ‘evoked’ Krox-24 expression was observed in L2–L6 segments of the dorsal horn ipsilateral to carrageenan inflammation. A maximal number of ‘evoked’ Krox-24 neurons was observed in L4–L5 segments, predominantly in the superficial laminae (I–II) and to a lesser extent in the medial part of neck (laminae V–VI) of the dorsal horn. Such an increase was not observed after an intraplantar injection of control vehicle saline. Increasing doses of carrageenan (1,3 and 6 mg) induced a dose-dependent increase (r2 = 0.617, P < 0.0001) in the number of ‘evoked’ Krox-24 neurons observed in the superficial dorsal horn 3 h after carrageenan. Systemic preadministration of indomethacin (1, 2.5 and 5 mg/kg) dose-dependently reduced (r2 = 0.508, P < 0.0001) the total number of carrageenan (6 mg at 3 h)-‘evoked’ Krox-24 neurons (29 ± 5, 45 ± 4 and 57 ± 2% reduction as compared with control, respectively). Systemic indomethacin dose-dependently reduced the inflamed paw and ankle diameter (16 ± 8, 34 ± 12, 54 ± 6% and 48 ± 14, 75 ± 16, 90 ± 7% reduction as compared with the control carrageenan inflammation, respectively). There was a positive correlation between the effect of systemic indomethacin on both ‘evoked’ Krox-24 expression in superficial laminae and the inflammatory signs (r2 = 0.25, P < 0.01 for the paw diameter; r2 = 0.22, P < 0.05 for the ankle diameter). In addition, the total number of ‘evoked’ Krox-24 neurons was significantly reduced (43 ± 5% reduction as compared with control) by an oral pretreatment of indomethacin (10 + 10 mg/kg). Oral indomethacin totally blocked the ankle diameter and reduced the paw diameter (100 ± 14 and 30 ± 6% reduction of the control carrageenan inflammation, respectively)." @default.
• W2094792326 created "2016-06-24" @default.
• W2094792326 creator A5040757035 @default.
• W2094792326 creator A5056963078 @default.
• W2094792326 creator A5078518818 @default.
• W2094792326 date "1995-03-01" @default.
• W2094792326 modified "2023-09-26" @default.
• W2094792326 title "Indomethacin reduces both Krox-24 expression in the rat lumbar spinal cord and inflammatory signs following intraplantar carrageenan" @default.
• W2094792326 cites W1512090235 @default.
• W2094792326 cites W1761965274 @default.
• W2094792326 cites W1868814633 @default.
• W2094792326 cites W1900996360 @default.
• W2094792326 cites W1958508359 @default.
• W2094792326 cites W1965584870 @default.
• W2094792326 cites W1967739579 @default.
• W2094792326 cites W1970474009 @default.
• W2094792326 cites W1984767179 @default.
• W2094792326 cites W1984862078 @default.
• W2094792326 cites W1988727926 @default.
• W2094792326 cites W1990044337 @default.
• W2094792326 cites W1991681848 @default.
• W2094792326 cites W1996462445 @default.
• W2094792326 cites W1997662455 @default.
• W2094792326 cites W2001026574 @default.
• W2094792326 cites W2004371641 @default.
• W2094792326 cites W2008574207 @default.
• W2094792326 cites W2014007136 @default.
• W2094792326 cites W2020632098 @default.
• W2094792326 cites W2022536454 @default.
• W2094792326 cites W2023430164 @default.
• W2094792326 cites W2033667415 @default.
• W2094792326 cites W2035274118 @default.
• W2094792326 cites W2035598134 @default.
• W2094792326 cites W2041272952 @default.
• W2094792326 cites W2047327104 @default.
• W2094792326 cites W2052840755 @default.
• W2094792326 cites W2060645936 @default.
• W2094792326 cites W2062250586 @default.
• W2094792326 cites W2064175661 @default.
• W2094792326 cites W2073134794 @default.
• W2094792326 cites W2075868413 @default.
• W2094792326 cites W2079154359 @default.
• W2094792326 cites W2081244369 @default.
• W2094792326 cites W2082895851 @default.
• W2094792326 cites W2084080149 @default.
• W2094792326 cites W2087454739 @default.
• W2094792326 cites W2089406505 @default.
• W2094792326 cites W2092996221 @default.
• W2094792326 cites W2096397256 @default.
• W2094792326 cites W2096428903 @default.
• W2094792326 cites W2098553579 @default.
• W2094792326 cites W2101033679 @default.
• W2094792326 cites W2107359522 @default.
• W2094792326 cites W2158067363 @default.
• W2094792326 cites W2161400543 @default.
• W2094792326 cites W2167604659 @default.
• W2094792326 cites W2170809837 @default.
• W2094792326 cites W4239425129 @default.
• W2094792326 doi "https://doi.org/10.1016/0006-8993(95)00009-f" @default.
• W2094792326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7796099" @default.
• W2094792326 hasPublicationYear "1995" @default.
• W2094792326 type Work @default.
• W2094792326 sameAs 2094792326 @default.
• W2094792326 citedByCount "17" @default.
• W2094792326 countsByYear W20947923262013 @default.
• W2094792326 countsByYear W20947923262014 @default.
• W2094792326 countsByYear W20947923262016 @default.
• W2094792326 countsByYear W20947923262019 @default.
• W2094792326 countsByYear W20947923262020 @default.
• W2094792326 crossrefType "journal-article" @default.
• W2094792326 hasAuthorship W2094792326A5040757035 @default.
• W2094792326 hasAuthorship W2094792326A5056963078 @default.
• W2094792326 hasAuthorship W2094792326A5078518818 @default.
• W2094792326 hasConcept C105702510 @default.
• W2094792326 hasConcept C118552586 @default.
• W2094792326 hasConcept C126322002 @default.
• W2094792326 hasConcept C134018914 @default.
• W2094792326 hasConcept C15490471 @default.
• W2094792326 hasConcept C170493617 @default.
• W2094792326 hasConcept C2776914184 @default.
• W2094792326 hasConcept C2777397205 @default.
• W2094792326 hasConcept C2780775167 @default.
• W2094792326 hasConcept C2781227287 @default.
• W2094792326 hasConcept C2909382400 @default.
• W2094792326 hasConcept C42219234 @default.
• W2094792326 hasConcept C44575665 @default.
• W2094792326 hasConcept C529278444 @default.
• W2094792326 hasConcept C71924100 @default.
• W2094792326 hasConcept C98274493 @default.
• W2094792326 hasConceptScore W2094792326C105702510 @default.
• W2094792326 hasConceptScore W2094792326C118552586 @default.
• W2094792326 hasConceptScore W2094792326C126322002 @default.
• W2094792326 hasConceptScore W2094792326C134018914 @default.
• W2094792326 hasConceptScore W2094792326C15490471 @default.
• W2094792326 hasConceptScore W2094792326C170493617 @default.
• W2094792326 hasConceptScore W2094792326C2776914184 @default.
• W2094792326 hasConceptScore W2094792326C2777397205 @default.
• W2094792326 hasConceptScore W2094792326C2780775167 @default.

• next