FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094799995> ?p ?o ?g. }

• W2094799995 endingPage "421" @default.
• W2094799995 startingPage "414" @default.
• W2094799995 abstract "Polygalae radix, the root of Polygala tenuifolia Willd, has commonly been used for the treatment of amnesia and anxiety in traditional Korean medicine. The aim of this study was to investigate its neuroprotective effects and possible mechanisms of action in models of Parkinson's disease. This study utilized a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, a reactive oxygen species (ROS) assay, a nitric oxide (NO) production assay, and a caspase-3 activity test as measures of cell viability in PC12 cells damaged by 6-hydroxydopamine (6-OHDA). The protective effects of PRE against 1-methyl-4-phenylpyridium (MPP+)-induced neurotoxicity were assessed in rat primary dopaminergic neurons and in a mouse PD model in which PRE was administered (100 mg/kg/day, 3 days, p.o.) before acute 1-mehtyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity. Finally, TH immunohistochemistry tests were conducted in the substantia nigra pars compacta (SNpc) and striatum (ST). PRE significantly inhibited 6-OHDA-induced cell damage at doses of 0.05–1 μg/ml with a maximal effect at 0.1 μg/ml. Caspase-3 activity and the production of ROS and NO were alleviated at 0.1 μg/ml. Also at this dose, PRE protected mesencephalic dopaminergic neurons from MPP+-induced toxicity. In an in vivo mouse model of PD, PRE protected dopaminergic neurons and fibers from MPTP-induced toxicity in the SNpc and ST. These results demonstrate that PRE has protective effects on dopaminergic neurons via its anti-oxidant and anti-apoptotic activity." @default.
• W2094799995 created "2016-06-24" @default.
• W2094799995 creator A5002179767 @default.
• W2094799995 creator A5012503420 @default.
• W2094799995 creator A5028095065 @default.
• W2094799995 creator A5041899584 @default.
• W2094799995 creator A5043061210 @default.
• W2094799995 creator A5051035208 @default.
• W2094799995 creator A5075115537 @default.
• W2094799995 date "2011-03-01" @default.
• W2094799995 modified "2023-10-17" @default.
• W2094799995 title "Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models" @default.
• W2094799995 cites W1982003799 @default.
• W2094799995 cites W1986402135 @default.
• W2094799995 cites W1993400038 @default.
• W2094799995 cites W1994990146 @default.
• W2094799995 cites W1998596454 @default.
• W2094799995 cites W2002506451 @default.
• W2094799995 cites W2004280801 @default.
• W2094799995 cites W2009706073 @default.
• W2094799995 cites W2011341174 @default.
• W2094799995 cites W2013713870 @default.
• W2094799995 cites W2036587359 @default.
• W2094799995 cites W2044269925 @default.
• W2094799995 cites W2051610473 @default.
• W2094799995 cites W2051761123 @default.
• W2094799995 cites W2055563997 @default.
• W2094799995 cites W2057323378 @default.
• W2094799995 cites W2057630288 @default.
• W2094799995 cites W2058016798 @default.
• W2094799995 cites W2058137293 @default.
• W2094799995 cites W2066548957 @default.
• W2094799995 cites W2070895853 @default.
• W2094799995 cites W2070945575 @default.
• W2094799995 cites W2087790613 @default.
• W2094799995 cites W2096298540 @default.
• W2094799995 cites W2109676963 @default.
• W2094799995 cites W2109893157 @default.
• W2094799995 cites W2111065594 @default.
• W2094799995 cites W2115818366 @default.
• W2094799995 cites W2129788038 @default.
• W2094799995 cites W2149959669 @default.
• W2094799995 cites W2152165298 @default.
• W2094799995 cites W2155124532 @default.
• W2094799995 cites W2157365984 @default.
• W2094799995 cites W2428475139 @default.
• W2094799995 cites W2952649964 @default.
• W2094799995 cites W62603772 @default.
• W2094799995 doi "https://doi.org/10.1016/j.jep.2010.12.030" @default.
• W2094799995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21195155" @default.
• W2094799995 hasPublicationYear "2011" @default.
• W2094799995 type Work @default.
• W2094799995 sameAs 2094799995 @default.
• W2094799995 citedByCount "72" @default.
• W2094799995 countsByYear W20947999952012 @default.
• W2094799995 countsByYear W20947999952013 @default.
• W2094799995 countsByYear W20947999952014 @default.
• W2094799995 countsByYear W20947999952015 @default.
• W2094799995 countsByYear W20947999952016 @default.
• W2094799995 countsByYear W20947999952017 @default.
• W2094799995 countsByYear W20947999952018 @default.
• W2094799995 countsByYear W20947999952019 @default.
• W2094799995 countsByYear W20947999952020 @default.
• W2094799995 countsByYear W20947999952021 @default.
• W2094799995 countsByYear W20947999952022 @default.
• W2094799995 countsByYear W20947999952023 @default.
• W2094799995 crossrefType "journal-article" @default.
• W2094799995 hasAuthorship W2094799995A5002179767 @default.
• W2094799995 hasAuthorship W2094799995A5012503420 @default.
• W2094799995 hasAuthorship W2094799995A5028095065 @default.
• W2094799995 hasAuthorship W2094799995A5041899584 @default.
• W2094799995 hasAuthorship W2094799995A5043061210 @default.
• W2094799995 hasAuthorship W2094799995A5051035208 @default.
• W2094799995 hasAuthorship W2094799995A5075115537 @default.
• W2094799995 hasConcept C126322002 @default.
• W2094799995 hasConcept C137183658 @default.
• W2094799995 hasConcept C185592680 @default.
• W2094799995 hasConcept C190283241 @default.
• W2094799995 hasConcept C25498285 @default.
• W2094799995 hasConcept C2776773494 @default.
• W2094799995 hasConcept C2778674702 @default.
• W2094799995 hasConcept C2779491297 @default.
• W2094799995 hasConcept C2780062018 @default.
• W2094799995 hasConcept C2780358027 @default.
• W2094799995 hasConcept C2780938664 @default.
• W2094799995 hasConcept C29730261 @default.
• W2094799995 hasConcept C48349386 @default.
• W2094799995 hasConcept C513476851 @default.
• W2094799995 hasConcept C53227056 @default.
• W2094799995 hasConcept C55493867 @default.
• W2094799995 hasConcept C71924100 @default.
• W2094799995 hasConcept C86803240 @default.
• W2094799995 hasConcept C98274493 @default.
• W2094799995 hasConceptScore W2094799995C126322002 @default.
• W2094799995 hasConceptScore W2094799995C137183658 @default.
• W2094799995 hasConceptScore W2094799995C185592680 @default.
• W2094799995 hasConceptScore W2094799995C190283241 @default.
• W2094799995 hasConceptScore W2094799995C25498285 @default.

• next