FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094808217> ?p ?o ?g. }

• W2094808217 endingPage "1178" @default.
• W2094808217 startingPage "1164" @default.
• W2094808217 abstract "Glial-derived neurotrophic factor (GDNF) promotes the survival and proliferation of enteric neurons. Neuropeptide Y (NPY) is an important peptide regulating gastrointestinal motility. The role of NPY on the survival and proliferation of enteric neurons is not known. We examined the effects of GDNF on the expression and release of NPY from enteric neurons and the role of NPY in promoting enteric neuronal proliferation and survival.Studies were performed in primary enteric neuronal cultures and NPY knockout mice (NPY(-/-)). GDNF-induced expression of NPY was assessed by reverse-transcription polymerase chain reaction (RT-PCR), immunocytochemistry, and enzyme-linked immunosorbent assay. Using NPY-siRNA and NPY-Y1 receptor antagonist, we examined the role of NPY in mediating the survival and proliferation effects of GDNF. Gastrointestinal motility was assessed by measuring gastric emptying, intestinal transit, and isometric muscle recording from intestinal muscle strips.GDNF induced a significant increase in NPY messenger RNA and protein expression in primary enteric neurons and the release of NPY into the culture medium. NPY (1 mumol/L) significantly increased proliferation of neurons and reduced apoptosis. In the presence of NPY-siRNA and NPY-Y1 receptor antagonist or in enteric neurons cultured from NPY(-/-) mice, GDNF-mediated neuronal proliferation and survival was reduced. NPY increased the phosphorylation of Akt, a downstream target of the PI-3-kinase pathway. In NPY(-/-) mice, there were significantly fewer nNOS-containing enteric neurons compared with wild-type (WT) mice. NPY(-/-) mice had accelerated gastric emptying and delayed intestinal transit compared with WT mice.We demonstrate that NPY acts as an autocrine neurotrophic factor for enteric neurons." @default.
• W2094808217 created "2016-06-24" @default.
• W2094808217 creator A5010433764 @default.
• W2094808217 creator A5012188262 @default.
• W2094808217 creator A5019353620 @default.
• W2094808217 creator A5039143614 @default.
• W2094808217 creator A5058978645 @default.
• W2094808217 creator A5063302307 @default.
• W2094808217 creator A5091361579 @default.
• W2094808217 date "2006-10-01" @default.
• W2094808217 modified "2023-09-30" @default.
• W2094808217 title "Glial-Derived Neurotrophic Factor Modulates Enteric Neuronal Survival and Proliferation Through Neuropeptide Y" @default.
• W2094808217 cites W1937309249 @default.
• W2094808217 cites W1963818675 @default.
• W2094808217 cites W1971208141 @default.
• W2094808217 cites W1978202073 @default.
• W2094808217 cites W1982144815 @default.
• W2094808217 cites W1983376554 @default.
• W2094808217 cites W1987566228 @default.
• W2094808217 cites W1990339051 @default.
• W2094808217 cites W1996246254 @default.
• W2094808217 cites W1997345434 @default.
• W2094808217 cites W1997706857 @default.
• W2094808217 cites W2002294810 @default.
• W2094808217 cites W2027322371 @default.
• W2094808217 cites W2027365233 @default.
• W2094808217 cites W2027379343 @default.
• W2094808217 cites W2030827743 @default.
• W2094808217 cites W2032996236 @default.
• W2094808217 cites W2034241069 @default.
• W2094808217 cites W2034939906 @default.
• W2094808217 cites W2036321843 @default.
• W2094808217 cites W2036781343 @default.
• W2094808217 cites W2037023832 @default.
• W2094808217 cites W2037787041 @default.
• W2094808217 cites W2040276280 @default.
• W2094808217 cites W2041025408 @default.
• W2094808217 cites W2043072647 @default.
• W2094808217 cites W2044278186 @default.
• W2094808217 cites W2049005201 @default.
• W2094808217 cites W2050772732 @default.
• W2094808217 cites W2051998916 @default.
• W2094808217 cites W2055952563 @default.
• W2094808217 cites W2058039522 @default.
• W2094808217 cites W2061482115 @default.
• W2094808217 cites W2064110992 @default.
• W2094808217 cites W2068634777 @default.
• W2094808217 cites W2068884677 @default.
• W2094808217 cites W2072159468 @default.
• W2094808217 cites W2072295587 @default.
• W2094808217 cites W2079474973 @default.
• W2094808217 cites W2079908366 @default.
• W2094808217 cites W2082584428 @default.
• W2094808217 cites W2085655953 @default.
• W2094808217 cites W2095765492 @default.
• W2094808217 cites W2105946812 @default.
• W2094808217 cites W2112454216 @default.
• W2094808217 cites W2122295014 @default.
• W2094808217 cites W2124312577 @default.
• W2094808217 cites W2128008306 @default.
• W2094808217 cites W2135872102 @default.
• W2094808217 cites W2136781148 @default.
• W2094808217 cites W2150094887 @default.
• W2094808217 cites W2155008473 @default.
• W2094808217 cites W2158346027 @default.
• W2094808217 cites W2163146547 @default.
• W2094808217 cites W2163520260 @default.
• W2094808217 cites W2168329818 @default.
• W2094808217 cites W2222118668 @default.
• W2094808217 doi "https://doi.org/10.1053/j.gastro.2006.07.019" @default.
• W2094808217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2349982" @default.
• W2094808217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17030186" @default.
• W2094808217 hasPublicationYear "2006" @default.
• W2094808217 type Work @default.
• W2094808217 sameAs 2094808217 @default.
• W2094808217 citedByCount "46" @default.
• W2094808217 countsByYear W20948082172012 @default.
• W2094808217 countsByYear W20948082172013 @default.
• W2094808217 countsByYear W20948082172014 @default.
• W2094808217 countsByYear W20948082172015 @default.
• W2094808217 countsByYear W20948082172016 @default.
• W2094808217 countsByYear W20948082172017 @default.
• W2094808217 countsByYear W20948082172019 @default.
• W2094808217 countsByYear W20948082172021 @default.
• W2094808217 countsByYear W20948082172022 @default.
• W2094808217 countsByYear W20948082172023 @default.
• W2094808217 crossrefType "journal-article" @default.
• W2094808217 hasAuthorship W2094808217A5010433764 @default.
• W2094808217 hasAuthorship W2094808217A5012188262 @default.
• W2094808217 hasAuthorship W2094808217A5019353620 @default.
• W2094808217 hasAuthorship W2094808217A5039143614 @default.
• W2094808217 hasAuthorship W2094808217A5058978645 @default.
• W2094808217 hasAuthorship W2094808217A5063302307 @default.
• W2094808217 hasAuthorship W2094808217A5091361579 @default.
• W2094808217 hasBestOaLocation W20948082172 @default.
• W2094808217 hasConcept C118303440 @default.
• W2094808217 hasConcept C126322002 @default.
• W2094808217 hasConcept C134018914 @default.

• next