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- W2094811234 endingPage "184" @default.
- W2094811234 startingPage "176" @default.
- W2094811234 abstract "Purpose of review Essential hypertension affects more than 20% of the adult population, and has a multifactorial origin arising from an interaction between susceptibility genes and environmental factors. Several strategies have been used to identify hypertension susceptibility genes. This review highlights recent efforts in genetic dissection of essential hypertension. Recent findings Recently, further chromosomal regions harboring blood pressure loci have emerged in genome-wide linkage studies. Findings from a new systematic two-dimensional genome scan are presented, as well as sex-specific loci linked to hypertension in inbred rodent models. Many case-control association studies have been carried out, but results so far have been equivocal. This review discusses some interesting studies combining linkage and association strategies using gene–gene interactions, and studies the use of haplotypes instead of SNPs. Two novel hypertension susceptibility genes are presented, and a short summary on new insights into genes of the renin–angiotensin and adrenergic systems is given. Summary To date, linkage and association studies have not been convincing. Genome-wide association studies may prove to be an effective approach to the problems posed by complex traits. Combined with candidate gene approaches, it is hoped this strategy will yield convincing evidence for genes associated with essential hypertension." @default.
- W2094811234 created "2016-06-24" @default.
- W2094811234 creator A5000012848 @default.
- W2094811234 date "2007-05-01" @default.
- W2094811234 modified "2023-10-12" @default.
- W2094811234 title "A review of the genetics of essential hypertension" @default.
- W2094811234 cites W1488559297 @default.
- W2094811234 cites W1930087082 @default.
- W2094811234 cites W1967582571 @default.
- W2094811234 cites W1969437239 @default.
- W2094811234 cites W1970493260 @default.
- W2094811234 cites W1973880725 @default.
- W2094811234 cites W1975768044 @default.
- W2094811234 cites W1976741643 @default.
- W2094811234 cites W1979069430 @default.
- W2094811234 cites W1979910363 @default.
- W2094811234 cites W1981642451 @default.
- W2094811234 cites W1987949023 @default.
- W2094811234 cites W1992970421 @default.
- W2094811234 cites W1993616653 @default.
- W2094811234 cites W1994834210 @default.
- W2094811234 cites W2011066442 @default.
- W2094811234 cites W2011377799 @default.
- W2094811234 cites W2012060608 @default.
- W2094811234 cites W2013101890 @default.
- W2094811234 cites W2015183535 @default.
- W2094811234 cites W2019373325 @default.
- W2094811234 cites W2022557753 @default.
- W2094811234 cites W2024002735 @default.
- W2094811234 cites W2029360044 @default.
- W2094811234 cites W2029461063 @default.
- W2094811234 cites W2033240204 @default.
- W2094811234 cites W2034652601 @default.
- W2094811234 cites W2036782927 @default.
- W2094811234 cites W2038099972 @default.
- W2094811234 cites W2038368878 @default.
- W2094811234 cites W2041556087 @default.
- W2094811234 cites W2041736813 @default.
- W2094811234 cites W2042103448 @default.
- W2094811234 cites W2049119185 @default.
- W2094811234 cites W2052724934 @default.
- W2094811234 cites W2053037307 @default.
- W2094811234 cites W2054868833 @default.
- W2094811234 cites W2054977086 @default.
- W2094811234 cites W2057318322 @default.
- W2094811234 cites W2057826553 @default.
- W2094811234 cites W2062945269 @default.
- W2094811234 cites W2064153978 @default.
- W2094811234 cites W2064807737 @default.
- W2094811234 cites W2067102410 @default.
- W2094811234 cites W2068203451 @default.
- W2094811234 cites W2073264424 @default.
- W2094811234 cites W2073881942 @default.
- W2094811234 cites W2080520706 @default.
- W2094811234 cites W2084073829 @default.
- W2094811234 cites W2085629494 @default.
- W2094811234 cites W2085855801 @default.
- W2094811234 cites W2087564451 @default.
- W2094811234 cites W2088886378 @default.
- W2094811234 cites W2092791310 @default.
- W2094811234 cites W2092810392 @default.
- W2094811234 cites W2094878675 @default.
- W2094811234 cites W2095631119 @default.
- W2094811234 cites W2099923659 @default.
- W2094811234 cites W2101899025 @default.
- W2094811234 cites W2104610568 @default.
- W2094811234 cites W2104823390 @default.
- W2094811234 cites W2105269157 @default.
- W2094811234 cites W2108221970 @default.
- W2094811234 cites W2108781484 @default.
- W2094811234 cites W2111099527 @default.
- W2094811234 cites W2113784410 @default.
- W2094811234 cites W2114814810 @default.
- W2094811234 cites W2114815161 @default.
- W2094811234 cites W2115655044 @default.
- W2094811234 cites W2116167198 @default.
- W2094811234 cites W2116626047 @default.
- W2094811234 cites W2119258997 @default.
- W2094811234 cites W2119287668 @default.
- W2094811234 cites W2122111235 @default.
- W2094811234 cites W2122745045 @default.
- W2094811234 cites W2123015368 @default.
- W2094811234 cites W2123170094 @default.
- W2094811234 cites W2123466824 @default.
- W2094811234 cites W2123609734 @default.
- W2094811234 cites W2123880706 @default.
- W2094811234 cites W2124663880 @default.
- W2094811234 cites W2130574974 @default.
- W2094811234 cites W2135115839 @default.
- W2094811234 cites W2135935011 @default.
- W2094811234 cites W2136461256 @default.
- W2094811234 cites W2137812180 @default.
- W2094811234 cites W2138305156 @default.
- W2094811234 cites W2139392061 @default.
- W2094811234 cites W2140853270 @default.
- W2094811234 cites W2141719916 @default.
- W2094811234 cites W2142766228 @default.
- W2094811234 cites W2144265893 @default.