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• W2094831008 startingPage "1549" @default.
• W2094831008 abstract "From Wnt Signals to Telomerase Activity Telomerase activity is associated with stem cell renewal and cancers, whereas a decrease in telomerase activity is seen during cell differentiation and senescence. Wnt/β-catenin signaling is also a critical regulator of stem cells, and deregulation of the pathway is associated with cancer. Now, Hoffmeyer et al. (p. 1549 ; see the Perspective by Greider ) have found a link between these two pathways. In embryonic stem cells, β-catenin was able to regulate telomerase expression and activity directly. Similar observations were obtained in adult stem cells, a model of intestinal tumors, and human cancer cells." @default.
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• W2094831008 date "2012-06-22" @default.
• W2094831008 modified "2023-10-14" @default.
• W2094831008 title "Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells" @default.
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• W2094831008 doi "https://doi.org/10.1126/science.1218370" @default.
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