FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094831080> ?p ?o ?g. }

• W2094831080 abstract "Apoptosis has been implicated in the pathophysiology of various forms of heart disease. Acute cellular rejection leads to morbidity after heart transplantation and invasive techniques are needed for its diagnosis. We investigated the presence of cardiomyocyte apoptosis in transplanted hearts, its progression, its relationship with rejection, and the possibility that serological markers of apoptosis can be used to detect rejection noninvasively.Overall, 130 endomyocardial biopsies obtained sequentially from 14 consecutive patients during the first 6 months following heart transplantation underwent histochemical analysis. The degree of acute rejection was determined, myocyte apoptosis was assessed using the TUNEL method, and caspase-3 activity was measured. In the first 10 patients, soluble Fas, tumor necrosis factor-alpha (TNFα) and interleukin 6 levels were determined in serum collected at biopsy.Apoptotic cells were detected in 81.5% of biopsies. No significant correlation was found between the apoptotic index and either the degree of rejection or the time from transplantation; there was only a trend to higher values during prolonged episodes of rejection, which did not reach statistical significance. An inverse correlation was observed between the degree of rejection and the TNFα level (rs=-0.33; P=.003). There was no correlation with any other variable.Cardiomyocyte loss due to apoptosis was observed in transplanted hearts, but no correlation was observed with either acute rejection or the time from transplantation. Our findings suggest there could be an inverse correlation between rejection and the serum TNFα level. No serum parameter evaluated was regarded as suitable for the noninvasive diagnosis of acute rejection." @default.
• W2094831080 created "2016-06-24" @default.
• W2094831080 creator A5003131400 @default.
• W2094831080 creator A5027382318 @default.
• W2094831080 creator A5050346471 @default.
• W2094831080 creator A5056388372 @default.
• W2094831080 creator A5059733947 @default.
• W2094831080 creator A5062257154 @default.
• W2094831080 date "2010-01-01" @default.
• W2094831080 modified "2023-09-29" @default.
• W2094831080 title "Apoptosis and Acute Cellular Rejection in Human Heart Transplants" @default.
• W2094831080 cites W123007742 @default.
• W2094831080 cites W1490480018 @default.
• W2094831080 cites W1607777232 @default.
• W2094831080 cites W1972185183 @default.
• W2094831080 cites W1973525716 @default.
• W2094831080 cites W1985202241 @default.
• W2094831080 cites W2023220359 @default.
• W2094831080 cites W2030538956 @default.
• W2094831080 cites W2044244138 @default.
• W2094831080 cites W2060018918 @default.
• W2094831080 cites W2064584294 @default.
• W2094831080 cites W2072699474 @default.
• W2094831080 cites W2075504429 @default.
• W2094831080 cites W2078413887 @default.
• W2094831080 cites W2085960789 @default.
• W2094831080 cites W2088749722 @default.
• W2094831080 cites W2108085416 @default.
• W2094831080 cites W2120278715 @default.
• W2094831080 cites W2123639044 @default.
• W2094831080 cites W2134221475 @default.
• W2094831080 cites W2146409834 @default.
• W2094831080 cites W2341478304 @default.
• W2094831080 cites W2409415937 @default.
• W2094831080 cites W2412566280 @default.
• W2094831080 cites W71378148 @default.
• W2094831080 doi "https://doi.org/10.1016/s1885-5857(10)70210-3" @default.
• W2094831080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20804702" @default.
• W2094831080 hasPublicationYear "2010" @default.
• W2094831080 type Work @default.
• W2094831080 sameAs 2094831080 @default.
• W2094831080 citedByCount "2" @default.
• W2094831080 countsByYear W20948310802014 @default.
• W2094831080 countsByYear W20948310802016 @default.
• W2094831080 crossrefType "journal-article" @default.
• W2094831080 hasAuthorship W2094831080A5003131400 @default.
• W2094831080 hasAuthorship W2094831080A5027382318 @default.
• W2094831080 hasAuthorship W2094831080A5050346471 @default.
• W2094831080 hasAuthorship W2094831080A5056388372 @default.
• W2094831080 hasAuthorship W2094831080A5059733947 @default.
• W2094831080 hasAuthorship W2094831080A5062257154 @default.
• W2094831080 hasConcept C10162356 @default.
• W2094831080 hasConcept C126322002 @default.
• W2094831080 hasConcept C142724271 @default.
• W2094831080 hasConcept C164705383 @default.
• W2094831080 hasConcept C17991360 @default.
• W2094831080 hasConcept C190283241 @default.
• W2094831080 hasConcept C196795494 @default.
• W2094831080 hasConcept C203014093 @default.
• W2094831080 hasConcept C204232928 @default.
• W2094831080 hasConcept C2775934546 @default.
• W2094831080 hasConcept C2778849806 @default.
• W2094831080 hasConcept C2780074459 @default.
• W2094831080 hasConcept C2911091166 @default.
• W2094831080 hasConcept C3019189323 @default.
• W2094831080 hasConcept C503630168 @default.
• W2094831080 hasConcept C55493867 @default.
• W2094831080 hasConcept C71924100 @default.
• W2094831080 hasConcept C86803240 @default.
• W2094831080 hasConceptScore W2094831080C10162356 @default.
• W2094831080 hasConceptScore W2094831080C126322002 @default.
• W2094831080 hasConceptScore W2094831080C142724271 @default.
• W2094831080 hasConceptScore W2094831080C164705383 @default.
• W2094831080 hasConceptScore W2094831080C17991360 @default.
• W2094831080 hasConceptScore W2094831080C190283241 @default.
• W2094831080 hasConceptScore W2094831080C196795494 @default.
• W2094831080 hasConceptScore W2094831080C203014093 @default.
• W2094831080 hasConceptScore W2094831080C204232928 @default.
• W2094831080 hasConceptScore W2094831080C2775934546 @default.
• W2094831080 hasConceptScore W2094831080C2778849806 @default.
• W2094831080 hasConceptScore W2094831080C2780074459 @default.
• W2094831080 hasConceptScore W2094831080C2911091166 @default.
• W2094831080 hasConceptScore W2094831080C3019189323 @default.
• W2094831080 hasConceptScore W2094831080C503630168 @default.
• W2094831080 hasConceptScore W2094831080C55493867 @default.
• W2094831080 hasConceptScore W2094831080C71924100 @default.
• W2094831080 hasConceptScore W2094831080C86803240 @default.
• W2094831080 hasLocation W20948310801 @default.
• W2094831080 hasLocation W20948310802 @default.
• W2094831080 hasOpenAccess W2094831080 @default.
• W2094831080 hasPrimaryLocation W20948310801 @default.
• W2094831080 hasRelatedWork W1564545013 @default.
• W2094831080 hasRelatedWork W1972197677 @default.
• W2094831080 hasRelatedWork W2016826747 @default.
• W2094831080 hasRelatedWork W2037258362 @default.
• W2094831080 hasRelatedWork W2039211841 @default.
• W2094831080 hasRelatedWork W2068489847 @default.
• W2094831080 hasRelatedWork W2312770960 @default.
• W2094831080 hasRelatedWork W2349728812 @default.
• W2094831080 hasRelatedWork W2375668620 @default.

• next