FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094838462> ?p ?o ?g. }

• W2094838462 endingPage "201" @default.
• W2094838462 startingPage "194" @default.
• W2094838462 abstract "Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages and dendritic cells. TREM-2 functions as a phagocytic receptor for bacteria as well as an inhibitor of Toll like receptors (TLR) induced inflammatory cytokines. However, the role of TREM-2 in Brucella intracellular growth remains unknown. To investigate whether TREM-2 is involved in Brucella intracellular survival, we chose bone marrow derived macrophages (BMDMs), in which TREM-2 is stably expressed, as cell model. Colony formation Units (CFUs) assay suggests that TREM-2 is involved in the internalization of Brucella abortus (B. abortus) by macrophages, while silencing of TREM-2 decreases intracellular survival of B. abortus. To further study the underlying mechanisms of TREM-2-mediated bacterial intracellular survival, we examined the activation of B. abortus-infected macrophages through determining the kinetics of activation of the three MAPKs, including ERK, JNK and p38, and measuring TNFα production in response to lipopolysaccharide (LPS) of Brucella (BrLPS) or B. abortus stimulation. Our data show that TREM-2 deficiency promotes activation of Brucella-infected macrophages. Moreover, our data also demonstrate that macrophage activation promotes killing of Brucella by enhancing nitric oxygen (NO), but not reactive oxygen species (ROS) production, macrophage apoptosis or cellular death. Taken together, these findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages." @default.
• W2094838462 created "2016-06-24" @default.
• W2094838462 creator A5001641032 @default.
• W2094838462 creator A5007758018 @default.
• W2094838462 creator A5015082334 @default.
• W2094838462 creator A5021409915 @default.
• W2094838462 creator A5052239051 @default.
• W2094838462 creator A5058278649 @default.
• W2094838462 creator A5058590640 @default.
• W2094838462 creator A5073143460 @default.
• W2094838462 date "2015-02-01" @default.
• W2094838462 modified "2023-09-24" @default.
• W2094838462 title "The role of TREM-2 in internalization and intracellular survival of Brucella abortus in murine macrophages" @default.
• W2094838462 cites W1563292811 @default.
• W2094838462 cites W1967840133 @default.
• W2094838462 cites W1987529403 @default.
• W2094838462 cites W1991218047 @default.
• W2094838462 cites W1996115289 @default.
• W2094838462 cites W2015918044 @default.
• W2094838462 cites W2041239222 @default.
• W2094838462 cites W2053175419 @default.
• W2094838462 cites W2071891769 @default.
• W2094838462 cites W2083428358 @default.
• W2094838462 cites W2083574264 @default.
• W2094838462 cites W2083674522 @default.
• W2094838462 cites W2083799755 @default.
• W2094838462 cites W2087749142 @default.
• W2094838462 cites W2090106964 @default.
• W2094838462 cites W2098478833 @default.
• W2094838462 cites W2101372125 @default.
• W2094838462 cites W2109491705 @default.
• W2094838462 cites W2118751252 @default.
• W2094838462 cites W2120747728 @default.
• W2094838462 cites W2121590561 @default.
• W2094838462 cites W2133084626 @default.
• W2094838462 cites W2149200346 @default.
• W2094838462 cites W2153478371 @default.
• W2094838462 cites W2166797590 @default.
• W2094838462 cites W2168525870 @default.
• W2094838462 cites W2170392236 @default.
• W2094838462 cites W2170841408 @default.
• W2094838462 cites W2283385829 @default.
• W2094838462 doi "https://doi.org/10.1016/j.vetimm.2014.12.007" @default.
• W2094838462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25563793" @default.
• W2094838462 hasPublicationYear "2015" @default.
• W2094838462 type Work @default.
• W2094838462 sameAs 2094838462 @default.
• W2094838462 citedByCount "15" @default.
• W2094838462 countsByYear W20948384622015 @default.
• W2094838462 countsByYear W20948384622016 @default.
• W2094838462 countsByYear W20948384622017 @default.
• W2094838462 countsByYear W20948384622018 @default.
• W2094838462 countsByYear W20948384622019 @default.
• W2094838462 countsByYear W20948384622020 @default.
• W2094838462 countsByYear W20948384622021 @default.
• W2094838462 countsByYear W20948384622022 @default.
• W2094838462 crossrefType "journal-article" @default.
• W2094838462 hasAuthorship W2094838462A5001641032 @default.
• W2094838462 hasAuthorship W2094838462A5007758018 @default.
• W2094838462 hasAuthorship W2094838462A5015082334 @default.
• W2094838462 hasAuthorship W2094838462A5021409915 @default.
• W2094838462 hasAuthorship W2094838462A5052239051 @default.
• W2094838462 hasAuthorship W2094838462A5058278649 @default.
• W2094838462 hasAuthorship W2094838462A5058590640 @default.
• W2094838462 hasAuthorship W2094838462A5073143460 @default.
• W2094838462 hasConcept C139770010 @default.
• W2094838462 hasConcept C153726182 @default.
• W2094838462 hasConcept C170493617 @default.
• W2094838462 hasConcept C202751555 @default.
• W2094838462 hasConcept C203014093 @default.
• W2094838462 hasConcept C2779244956 @default.
• W2094838462 hasConcept C2780767784 @default.
• W2094838462 hasConcept C2781429187 @default.
• W2094838462 hasConcept C55493867 @default.
• W2094838462 hasConcept C79879829 @default.
• W2094838462 hasConcept C86803240 @default.
• W2094838462 hasConcept C89423630 @default.
• W2094838462 hasConcept C95444343 @default.
• W2094838462 hasConceptScore W2094838462C139770010 @default.
• W2094838462 hasConceptScore W2094838462C153726182 @default.
• W2094838462 hasConceptScore W2094838462C170493617 @default.
• W2094838462 hasConceptScore W2094838462C202751555 @default.
• W2094838462 hasConceptScore W2094838462C203014093 @default.
• W2094838462 hasConceptScore W2094838462C2779244956 @default.
• W2094838462 hasConceptScore W2094838462C2780767784 @default.
• W2094838462 hasConceptScore W2094838462C2781429187 @default.
• W2094838462 hasConceptScore W2094838462C55493867 @default.
• W2094838462 hasConceptScore W2094838462C79879829 @default.
• W2094838462 hasConceptScore W2094838462C86803240 @default.
• W2094838462 hasConceptScore W2094838462C89423630 @default.
• W2094838462 hasConceptScore W2094838462C95444343 @default.
• W2094838462 hasFunder F4320321001 @default.
• W2094838462 hasFunder F4320322300 @default.
• W2094838462 hasIssue "3-4" @default.
• W2094838462 hasLocation W20948384621 @default.
• W2094838462 hasLocation W20948384622 @default.
• W2094838462 hasOpenAccess W2094838462 @default.
• W2094838462 hasPrimaryLocation W20948384621 @default.

• next