FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094839530> ?p ?o ?g. }

• W2094839530 endingPage "470" @default.
• W2094839530 startingPage "464" @default.
• W2094839530 abstract "Introduction In addition to acquired and inherited risk factors, the growth of venous thrombus under static conditions and endothelial injury play important roles in the development of deep venous thrombosis (DVT), for which risk factors include increased plasma levels of coagulation factor XI (FXI). The aim of this study is to understand the role of FXI in venous thrombus formation under conditions of endothelial denudation and/or blood stasis. Materials and methods The contribution of FXI to venous thrombus formation was investigated in a rabbit model and a flow chamber system. Thrombi were induced in the rabbit jugular veins by (1) endothelial denudation, (2) vessel ligation (blood stasis) or (3) by combined endothelial denudation and vessel ligation. Blood samples were perfused on immobilized type III collagen at a wall shear rate of 70/s and then the surface area covered by platelets and fibrin was morphometrically evaluated. Prothrombin fragment 1+2 (F1+2) generation was also measured before and after perfusion. Results All thrombi induced in rabbit jugular veins were composed of platelets, fibrin and erythrocytes. Anti-FXI antibody significantly reduced ex vivo plasma thrombin generation initiated by ellagic acid but not by tissue factor, and in vivo thrombus formation under endothelial denudation and/or vessel ligation. The antibody significantly reduced surface areas covered by platelets and fibrin, as well as F1+2 generation at a wall shear rate of 70/s in flow chambers. Conclusion These results suggest that FXI contributes to venous thrombus growth under conditions of endothelial denudation and/or blood stasis, and that thrombin generation by FXI interaction promotes further platelet aggregation and fibrin formation at low shear rates." @default.
• W2094839530 created "2016-06-24" @default.
• W2094839530 creator A5010392419 @default.
• W2094839530 creator A5010659470 @default.
• W2094839530 creator A5011382201 @default.
• W2094839530 creator A5013907733 @default.
• W2094839530 creator A5017307924 @default.
• W2094839530 creator A5050121484 @default.
• W2094839530 creator A5050458359 @default.
• W2094839530 creator A5051382077 @default.
• W2094839530 creator A5072777516 @default.
• W2094839530 creator A5077363907 @default.
• W2094839530 creator A5081554573 @default.
• W2094839530 date "2010-05-01" @default.
• W2094839530 modified "2023-10-06" @default.
• W2094839530 title "Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis" @default.
• W2094839530 cites W1493020617 @default.
• W2094839530 cites W1531288520 @default.
• W2094839530 cites W1550445291 @default.
• W2094839530 cites W1599640293 @default.
• W2094839530 cites W1757375456 @default.
• W2094839530 cites W1828989025 @default.
• W2094839530 cites W1971784860 @default.
• W2094839530 cites W1976892879 @default.
• W2094839530 cites W1982752835 @default.
• W2094839530 cites W1985416926 @default.
• W2094839530 cites W1987671820 @default.
• W2094839530 cites W1992989611 @default.
• W2094839530 cites W2000971803 @default.
• W2094839530 cites W2004761712 @default.
• W2094839530 cites W2015228310 @default.
• W2094839530 cites W2019414888 @default.
• W2094839530 cites W2025166282 @default.
• W2094839530 cites W2027503402 @default.
• W2094839530 cites W2031677121 @default.
• W2094839530 cites W2067224456 @default.
• W2094839530 cites W2072299517 @default.
• W2094839530 cites W2072344433 @default.
• W2094839530 cites W2087350779 @default.
• W2094839530 cites W2092401570 @default.
• W2094839530 cites W2116400438 @default.
• W2094839530 cites W2117944864 @default.
• W2094839530 cites W2120677427 @default.
• W2094839530 cites W2130735492 @default.
• W2094839530 cites W2132984496 @default.
• W2094839530 cites W2133926184 @default.
• W2094839530 cites W2138712613 @default.
• W2094839530 cites W2140193483 @default.
• W2094839530 cites W2143201729 @default.
• W2094839530 cites W2168719124 @default.
• W2094839530 cites W2226999514 @default.
• W2094839530 cites W2338854794 @default.
• W2094839530 cites W295511661 @default.
• W2094839530 cites W4249053801 @default.
• W2094839530 doi "https://doi.org/10.1016/j.thromres.2009.12.013" @default.
• W2094839530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20089298" @default.
• W2094839530 hasPublicationYear "2010" @default.
• W2094839530 type Work @default.
• W2094839530 sameAs 2094839530 @default.
• W2094839530 citedByCount "29" @default.
• W2094839530 countsByYear W20948395302012 @default.
• W2094839530 countsByYear W20948395302013 @default.
• W2094839530 countsByYear W20948395302014 @default.
• W2094839530 countsByYear W20948395302015 @default.
• W2094839530 countsByYear W20948395302016 @default.
• W2094839530 countsByYear W20948395302018 @default.
• W2094839530 countsByYear W20948395302019 @default.
• W2094839530 countsByYear W20948395302020 @default.
• W2094839530 countsByYear W20948395302022 @default.
• W2094839530 countsByYear W20948395302023 @default.
• W2094839530 crossrefType "journal-article" @default.
• W2094839530 hasAuthorship W2094839530A5010392419 @default.
• W2094839530 hasAuthorship W2094839530A5010659470 @default.
• W2094839530 hasAuthorship W2094839530A5011382201 @default.
• W2094839530 hasAuthorship W2094839530A5013907733 @default.
• W2094839530 hasAuthorship W2094839530A5017307924 @default.
• W2094839530 hasAuthorship W2094839530A5050121484 @default.
• W2094839530 hasAuthorship W2094839530A5050458359 @default.
• W2094839530 hasAuthorship W2094839530A5051382077 @default.
• W2094839530 hasAuthorship W2094839530A5072777516 @default.
• W2094839530 hasAuthorship W2094839530A5077363907 @default.
• W2094839530 hasAuthorship W2094839530A5081554573 @default.
• W2094839530 hasConcept C126322002 @default.
• W2094839530 hasConcept C142724271 @default.
• W2094839530 hasConcept C150903083 @default.
• W2094839530 hasConcept C164705383 @default.
• W2094839530 hasConcept C203014093 @default.
• W2094839530 hasConcept C207001950 @default.
• W2094839530 hasConcept C26291073 @default.
• W2094839530 hasConcept C2777956836 @default.
• W2094839530 hasConcept C2779036427 @default.
• W2094839530 hasConcept C2780868729 @default.
• W2094839530 hasConcept C2781362458 @default.
• W2094839530 hasConcept C54173615 @default.
• W2094839530 hasConcept C71924100 @default.
• W2094839530 hasConcept C86803240 @default.
• W2094839530 hasConcept C89560881 @default.
• W2094839530 hasConceptScore W2094839530C126322002 @default.

• next