FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094842938> ?p ?o ?g. }

• W2094842938 endingPage "843" @default.
• W2094842938 startingPage "834" @default.
• W2094842938 abstract "Sugar consumption and subsequent sugar metabolism are known to regulate the expression of genes involved in intestinal sugar absorption and delivery. Here we investigate the hypothesis that sugar-sensing detectors in membranes facing the intestinal lumen or the bloodstream can also modulate intestinal sugar absorption. We used wild-type and GLUT2-null mice, to show that dietary sugars stimulate the expression of sucrase-isomaltase (SI) and L-pyruvate kinase (L-PK) by GLUT2-dependent mechanisms, whereas the expression of GLUT5 and SGLT1, did not rely on the presence of GLUT2. By providing sugar metabolites, sugar transporters, including GLUT2, fuelled a sensing pathway. In Caco2/TC7 enterocytes, we could disconnect the sensing triggered by detector from that produced by metabolism, and found that GLUT2 generated a metabolism-independent pathway to stimulate the expression of SI and L-PK. In cultured enterocytes, both apical and basolateral fructose could increase the expression of GLUT5, conversely, basolateral sugar administration could stimulate the expression of GLUT2. Finally, we located the sweet-taste receptors T1R3 and T1R2 in plasma membranes, and we measured their cognate G alpha Gustducin mRNA levels. Furthermore, we showed that a T1R3 inhibitor altered the fructose-induced expression of SGLT1, GLUT5, and L-PK. Intestinal gene expression is thus controlled by a combination of at least three sugar-signaling pathways triggered by sugar metabolites and membrane sugar receptors that, according to membrane location, determine sugar-sensing polarity. This provides a rationale for how intestine adapts sugar delivery to blood and dietary sugar provision." @default.
• W2094842938 created "2016-06-24" @default.
• W2094842938 creator A5005648054 @default.
• W2094842938 creator A5021138568 @default.
• W2094842938 creator A5034908400 @default.
• W2094842938 creator A5065190347 @default.
• W2094842938 creator A5073466945 @default.
• W2094842938 creator A5090873496 @default.
• W2094842938 date "2007-09-04" @default.
• W2094842938 modified "2023-10-10" @default.
• W2094842938 title "Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism" @default.
• W2094842938 cites W1516591406 @default.
• W2094842938 cites W1811863214 @default.
• W2094842938 cites W1841510558 @default.
• W2094842938 cites W1849405398 @default.
• W2094842938 cites W1885267328 @default.
• W2094842938 cites W1954362441 @default.
• W2094842938 cites W1960694886 @default.
• W2094842938 cites W1964137071 @default.
• W2094842938 cites W1975927357 @default.
• W2094842938 cites W1980747853 @default.
• W2094842938 cites W1982350812 @default.
• W2094842938 cites W1985233399 @default.
• W2094842938 cites W1998742561 @default.
• W2094842938 cites W2000045912 @default.
• W2094842938 cites W2005614924 @default.
• W2094842938 cites W2023326549 @default.
• W2094842938 cites W2023939486 @default.
• W2094842938 cites W2027162538 @default.
• W2094842938 cites W2029154514 @default.
• W2094842938 cites W2030769846 @default.
• W2094842938 cites W2032619610 @default.
• W2094842938 cites W2037028566 @default.
• W2094842938 cites W2037338352 @default.
• W2094842938 cites W2043973752 @default.
• W2094842938 cites W2054842789 @default.
• W2094842938 cites W2058924440 @default.
• W2094842938 cites W2072707799 @default.
• W2094842938 cites W2073115006 @default.
• W2094842938 cites W2077820110 @default.
• W2094842938 cites W2080393543 @default.
• W2094842938 cites W2082824826 @default.
• W2094842938 cites W2083715780 @default.
• W2094842938 cites W2083819344 @default.
• W2094842938 cites W2086812198 @default.
• W2094842938 cites W2090847725 @default.
• W2094842938 cites W2091277139 @default.
• W2094842938 cites W2092971843 @default.
• W2094842938 cites W2097088760 @default.
• W2094842938 cites W2116233022 @default.
• W2094842938 cites W2121864128 @default.
• W2094842938 cites W2121973484 @default.
• W2094842938 cites W2132725991 @default.
• W2094842938 cites W2134948484 @default.
• W2094842938 cites W2147920556 @default.
• W2094842938 cites W2150899357 @default.
• W2094842938 cites W2153160690 @default.
• W2094842938 cites W2155375136 @default.
• W2094842938 cites W2159036256 @default.
• W2094842938 cites W2171142773 @default.
• W2094842938 cites W2182875022 @default.
• W2094842938 cites W2224734909 @default.
• W2094842938 cites W2404082640 @default.
• W2094842938 cites W4233931883 @default.
• W2094842938 cites W4249590403 @default.
• W2094842938 doi "https://doi.org/10.1002/jcp.21245" @default.
• W2094842938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17786952" @default.
• W2094842938 hasPublicationYear "2007" @default.
• W2094842938 type Work @default.
• W2094842938 sameAs 2094842938 @default.
• W2094842938 citedByCount "63" @default.
• W2094842938 countsByYear W20948429382012 @default.
• W2094842938 countsByYear W20948429382013 @default.
• W2094842938 countsByYear W20948429382014 @default.
• W2094842938 countsByYear W20948429382015 @default.
• W2094842938 countsByYear W20948429382016 @default.
• W2094842938 countsByYear W20948429382017 @default.
• W2094842938 countsByYear W20948429382018 @default.
• W2094842938 countsByYear W20948429382021 @default.
• W2094842938 crossrefType "journal-article" @default.
• W2094842938 hasAuthorship W2094842938A5005648054 @default.
• W2094842938 hasAuthorship W2094842938A5021138568 @default.
• W2094842938 hasAuthorship W2094842938A5034908400 @default.
• W2094842938 hasAuthorship W2094842938A5065190347 @default.
• W2094842938 hasAuthorship W2094842938A5073466945 @default.
• W2094842938 hasAuthorship W2094842938A5090873496 @default.
• W2094842938 hasBestOaLocation W20948429381 @default.
• W2094842938 hasConcept C104317684 @default.
• W2094842938 hasConcept C134018914 @default.
• W2094842938 hasConcept C150194340 @default.
• W2094842938 hasConcept C161573976 @default.
• W2094842938 hasConcept C17093226 @default.
• W2094842938 hasConcept C185592680 @default.
• W2094842938 hasConcept C2776970464 @default.
• W2094842938 hasConcept C2777108408 @default.
• W2094842938 hasConcept C2777901630 @default.
• W2094842938 hasConcept C2779306644 @default.
• W2094842938 hasConcept C55493867 @default.

• next