FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094844891> ?p ?o ?g. }

• W2094844891 endingPage "174" @default.
• W2094844891 startingPage "166" @default.
• W2094844891 abstract "In the search to detect genetic associations between complex traits and DNA variants, a practice is to select a subset of Single Nucleotide Polymorphisms (tag SNPs) in a gene or chromosomal region of interest. This allows study of untyped polymorphisms in this region through the phenomenon of linkage disequilibrium (LD). However, it is crucial in the analysis to utilize such multiple SNP markers efficiently. In this study, we present a robust testing approach (TC) that combines single marker association test statistics or p values. This combination is based on the summation of single test statistics or p values, giving greater weight to those with lower p values. We compared the powers of TC in identifying common trait loci, using tag SNPs within the same haplotype block that the trait loci reside, with competing published tests, in case-control settings. These competing tests included the Bonferroni procedure (TB), the simple permutation procedure (TP), the permutation procedure proposed by Hoh et al. (TP-H) and its revised version using ‘deflated’ statistics (TP-H_def), the traditional χ2 procedure (TCHI), the regression procedure (Hotelling T2 test) (TR) and the haplotype-based test (TH). Results of these comparisons show that our proposed combining procedure (TC) is preferred in all scenarios examined. We also apply this new test to a data set from a previously reported association study on airway responsiveness to methacholine." @default.
• W2094844891 created "2016-06-24" @default.
• W2094844891 creator A5027133672 @default.
• W2094844891 creator A5037645443 @default.
• W2094844891 creator A5065829677 @default.
• W2094844891 date "2008-01-01" @default.
• W2094844891 modified "2023-09-23" @default.
• W2094844891 title "Combining Association Tests across Multiple Genetic Markers in Case-Control Studies" @default.
• W2094844891 cites W1508985588 @default.
• W2094844891 cites W1583476286 @default.
• W2094844891 cites W1971771243 @default.
• W2094844891 cites W1972028609 @default.
• W2094844891 cites W1978136073 @default.
• W2094844891 cites W1978136801 @default.
• W2094844891 cites W1989804913 @default.
• W2094844891 cites W2012642411 @default.
• W2094844891 cites W2015408724 @default.
• W2094844891 cites W2019854250 @default.
• W2094844891 cites W2021535444 @default.
• W2094844891 cites W2021930039 @default.
• W2094844891 cites W2025306791 @default.
• W2094844891 cites W2028142113 @default.
• W2094844891 cites W2029784047 @default.
• W2094844891 cites W2031873733 @default.
• W2094844891 cites W2042103448 @default.
• W2094844891 cites W2047016358 @default.
• W2094844891 cites W2050856199 @default.
• W2094844891 cites W2090430326 @default.
• W2094844891 cites W2099324779 @default.
• W2094844891 cites W2102109283 @default.
• W2094844891 cites W2108237262 @default.
• W2094844891 cites W2109342343 @default.
• W2094844891 cites W2116260634 @default.
• W2094844891 cites W2129245687 @default.
• W2094844891 cites W2130209732 @default.
• W2094844891 cites W2135732313 @default.
• W2094844891 cites W2152664025 @default.
• W2094844891 cites W2162530578 @default.
• W2094844891 cites W2162647412 @default.
• W2094844891 cites W2217809488 @default.
• W2094844891 doi "https://doi.org/10.1159/000109733" @default.
• W2094844891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17940337" @default.
• W2094844891 hasPublicationYear "2008" @default.
• W2094844891 type Work @default.
• W2094844891 sameAs 2094844891 @default.
• W2094844891 citedByCount "2" @default.
• W2094844891 crossrefType "journal-article" @default.
• W2094844891 hasAuthorship W2094844891A5027133672 @default.
• W2094844891 hasAuthorship W2094844891A5037645443 @default.
• W2094844891 hasAuthorship W2094844891A5065829677 @default.
• W2094844891 hasConcept C104317684 @default.
• W2094844891 hasConcept C105795698 @default.
• W2094844891 hasConcept C121332964 @default.
• W2094844891 hasConcept C127808970 @default.
• W2094844891 hasConcept C135763542 @default.
• W2094844891 hasConcept C139275648 @default.
• W2094844891 hasConcept C153209595 @default.
• W2094844891 hasConcept C180754005 @default.
• W2094844891 hasConcept C183905921 @default.
• W2094844891 hasConcept C186413461 @default.
• W2094844891 hasConcept C193244246 @default.
• W2094844891 hasConcept C197754878 @default.
• W2094844891 hasConcept C21308566 @default.
• W2094844891 hasConcept C24890656 @default.
• W2094844891 hasConcept C33923547 @default.
• W2094844891 hasConcept C35605836 @default.
• W2094844891 hasConcept C54355233 @default.
• W2094844891 hasConcept C55060382 @default.
• W2094844891 hasConcept C86803240 @default.
• W2094844891 hasConceptScore W2094844891C104317684 @default.
• W2094844891 hasConceptScore W2094844891C105795698 @default.
• W2094844891 hasConceptScore W2094844891C121332964 @default.
• W2094844891 hasConceptScore W2094844891C127808970 @default.
• W2094844891 hasConceptScore W2094844891C135763542 @default.
• W2094844891 hasConceptScore W2094844891C139275648 @default.
• W2094844891 hasConceptScore W2094844891C153209595 @default.
• W2094844891 hasConceptScore W2094844891C180754005 @default.
• W2094844891 hasConceptScore W2094844891C183905921 @default.
• W2094844891 hasConceptScore W2094844891C186413461 @default.
• W2094844891 hasConceptScore W2094844891C193244246 @default.
• W2094844891 hasConceptScore W2094844891C197754878 @default.
• W2094844891 hasConceptScore W2094844891C21308566 @default.
• W2094844891 hasConceptScore W2094844891C24890656 @default.
• W2094844891 hasConceptScore W2094844891C33923547 @default.
• W2094844891 hasConceptScore W2094844891C35605836 @default.
• W2094844891 hasConceptScore W2094844891C54355233 @default.
• W2094844891 hasConceptScore W2094844891C55060382 @default.
• W2094844891 hasConceptScore W2094844891C86803240 @default.
• W2094844891 hasIssue "3" @default.
• W2094844891 hasLocation W20948448911 @default.
• W2094844891 hasLocation W20948448912 @default.
• W2094844891 hasOpenAccess W2094844891 @default.
• W2094844891 hasPrimaryLocation W20948448911 @default.
• W2094844891 hasRelatedWork W1966708416 @default.
• W2094844891 hasRelatedWork W2059137285 @default.
• W2094844891 hasRelatedWork W2071146638 @default.
• W2094844891 hasRelatedWork W2075926380 @default.
• W2094844891 hasRelatedWork W2091502902 @default.

• next