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- W2094845811 abstract "<h3>Context</h3>The pathogenesis of depression is not fully understood, but studies suggest that low-grade systemic inflammation contributes to the development of depression.<h3>Objective</h3>To test whether elevated plasma levels of C-reactive protein (CRP) are associated with psychological distress and depression.<h3>Design</h3>We performed cross-sectional and prospective analyses of CRP levels in 4 clinically relevant categories using data from 2 general population studies.<h3>Setting</h3>The Copenhagen General Population and the Copenhagen City Heart studies.<h3>Participants</h3>We examined 73 131 men and women aged 20 to 100 years.<h3>Main Outcome Measures</h3>We ascertained psychological distress with 2 single-item self-reports and depression using self-reported antidepressant use, register-based prescription of antidepressants, and register-based hospitalization with depression.<h3>Results</h3>In cross-sectional analyses, increasing CRP levels were associated with increasing risk for psychological distress and depression (P = 3 × 10<sup>−8</sup> to P = 4 × 10<sup>−105</sup> for trend). For self-reported use of antidepressants, the odds ratio was 1.38 (95% CI, 1.23-1.55) for CRP levels of 1.01 to 3.00 mg/L, 2.02 (1.77-2.30) for 3.01 to 10.00 mg/L, and 2.70 (2.25-3.25) for greater than 10.00 mg/L compared with 0.01 to 1.00 mg/L. For prescription of antidepressants, the corresponding odds ratios were 1.08 (95% CI, 0.99-1.17), 1.47 (1.33-1.62), and 1.77 (1.52-2.05), respectively; for hospitalization with depression, 1.30 (1.01-1.67), 1.84 (1.39-2.43), and 2.27 (1.54-3.32), respectively. In prospective analyses, increasing CRP levels were also associated with increasing risk for hospitalization with depression (P = 4 × 10<sup>−8</sup> for trend).<h3>Conclusions</h3>Elevated levels of CRP are associated with increased risk for psychological distress and depression in the general population." @default.
- W2094845811 created "2016-06-24" @default.
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- W2094845811 date "2013-02-01" @default.
- W2094845811 modified "2023-10-01" @default.
- W2094845811 title "Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals" @default.
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- W2094845811 doi "https://doi.org/10.1001/2013.jamapsychiatry.102" @default.
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