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- W2094853010 abstract "Abstract Recently, in order to improve drug permeation through the skin, penetration enhancers have attracted a great deal of interest in increasing percutaneous absorption. Natural compounds like terpenes have been suggested as promising non-toxic, non-irritating transdermal penetration enhancers. This investigation aimed to study the effect of extract and essential oil of Eryngium bungei (as a traditional anti-inflammatory and antinociceptive) on the transdermal absorption of piroxicam. The stable gel was chosen and enhancing effects of plant extract and essential oil with different concentrations (0.5 - 3.0 and 0.25 - 5.0 % w/w respectively) on the permeation of piroxicam were evaluated. The results showed that the greatest enhancement of the skin transport occurs at the highest concentration of the enhancer (P < 0.01). The most outstanding penetration enhancer was plant essential oil in 5 % w/w, providing an almost 9.17-fold increase in permeability coefficient of piroxicam. Key words: Penetration enhancer E. bungei extractessential oilpiroxicampercutaneousGC-MS" @default.
- W2094853010 created "2016-06-24" @default.
- W2094853010 creator A5033544451 @default.
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- W2094853010 date "2009-01-01" @default.
- W2094853010 modified "2023-09-27" @default.
- W2094853010 title "Penetration-Enhancing Effect of the Essential Oil and Methanolic Extract of<i>Eryngium bungei</i>on Percutaneous Absorption of Piroxicam through Rat Skin" @default.
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- W2094853010 doi "https://doi.org/10.1080/0972060x.2009.10643782" @default.
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