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• W2094865207 endingPage "440" @default.
• W2094865207 startingPage "430" @default.
• W2094865207 abstract "Data from animal and human studies suggest that the rate of progression of renal insufficiency can be retarded with careful control of blood pressure, institution of a low-protein diet, and the use of lipid-lowering agents. These therapeutic interventions become important when managing patients with renal insufficiency secondary to autosomal dominant polycystic kidney disease (PKD) and autosomal recessive polycystic kidney disease, in which end-stage renal disease is present in nearly 17,000 individuals per year. Several dietary and pharmacologic intervention strategies including blood pressure control, dietary modification, and the use of antioxidants as well as lipid-lowering agents have been studied in humans and animals with PKD in an effort to slow the rate of renal progression. This article reviews the current understanding of the effectiveness of these conventional therapies, as well as novel therapies that specifically target the mediators of cyst formation in PKD using tyrosine kinase inhibitors and gene therapy in an effort to identify potential strategies for retarding cyst formation and parenchymal injury in PKD. Current pharmacologic and dietary strategies fail to show any consistent benefits in preserving renal function and reducing renal injury in human PKD. The therapeutic potential for exciting new gene therapies and pharmacologic agents designed to target the pathophysiologic pathways involved in cyst formation are promising. Randomized, controlled trials in children and adults with early PKD are necessary to evaluate the effectiveness of these therapeutic interventions." @default.
• W2094865207 created "2016-06-24" @default.
• W2094865207 creator A5072484694 @default.
• W2094865207 creator A5080213741 @default.
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• W2094865207 creator A5087152545 @default.
• W2094865207 date "2001-09-01" @default.
• W2094865207 modified "2023-10-18" @default.
• W2094865207 title "Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented?" @default.
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