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• W2094865272 abstract "We quantified the binding potentials ( BP ND ) of [ 11 C]yohimbine binding in rat brain to alpha-2 adrenoceptors to evaluate [ 11 C]yohimbine as an in vivo marker of noradrenergic neurotransmission and to examine its sensitivity to the level of noradrenaline. Dual [ 11 C]yohimbine dynamic positron emission tomography (PET) recordings were applied to five Sprague Dawley rats at baseline, followed by acute amphetamine administration (2 mg/kg) to induce elevation of the endogenous level of noradrenaline. The volume of distribution ( V T ) of [ 11 C]yohimbine was obtained using Logan plot with arterial plasma input. Because alpha-2 adrenoceptors are distributed throughout the brain, the estimation of the BP ND is complicated by the absence of an anatomic region of no displaceable binding. We used the Inhibition plot to acquire the reference volume, V ND , from which we calculated the BP ND . Acute pharmacological challenge with amphetamine induced a significant decline of [ 11 C]yohimbine BP ND of ∼38% in all volumes of interest. The BP ND was greatest in the thalamus and striatum, followed in descending order by, frontal cortex, pons, and cerebellum. The experimental data demonstrate that [ 11 C]yohimbine binding is sensitive to a challenge known to increase the extracellular level of noradrenaline, which can benefit future PET investigations of pathologic conditions related to disrupted noradrenergic neurotransmission." @default.
• W2094865272 created "2016-06-24" @default.
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• W2094865272 date "2015-03-01" @default.
• W2094865272 modified "2023-10-17" @default.
• W2094865272 title "Quantification of [¹¹C]yohimbine Binding to α₂ Adrenoceptors in Rat Brain <i>in vivo</i>" @default.
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• W2094865272 doi "https://doi.org/10.1038/jcbfm.2014.225" @default.
• W2094865272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4348393" @default.
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