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- W2094868137 abstract "By screening of cDNA and genomic libraries of Plasmodium falciparum with a DNA probe derived from the cognate β-tubulin gene, gene Pfγtub has been identified that codes for γ-tubulin, a newly discovered member of the tubulin superfamily that is indispensible for nuclear division and microtubule assembly [12]. Gene Pfγtub is not interrupted by introns and only present as a single-copy in the parasite genome. Its encoded amino acid sequence (452 amino acids; Mr 50 560) has a 63% similarity to the γ-tubulins encoded by Aspergillus nidulans, Schizosaccharomyces pombe, Drosophila melanogaster, Xenopus laevis and Homo sapiens. This figure is significantly (approx. 8%) lower than the average identity between the γ-tubulins of the latter five species suggesting that during evolution the genes have been exposed to different selection pressures. The identity of γ-tubulin to the Plasmodium falciparum encoded α- and β-tubulins is 30 and 33%, respectively." @default.
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- W2094868137 date "1993-07-01" @default.
- W2094868137 modified "2023-10-18" @default.
- W2094868137 title "The γ-tubulin gene of the malaria parasite Plasmodium falciparum" @default.
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- W2094868137 doi "https://doi.org/10.1016/0166-6851(93)90025-s" @default.
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