FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094872917> ?p ?o ?g. }

• W2094872917 endingPage "1155" @default.
• W2094872917 startingPage "1146" @default.
• W2094872917 abstract "Beta2-glycoprotein I (beta2GPI) is an important autoantigen in the antiphospholipid syndrome (APS). In vitro studies suggest that it may have multifaceted physiologic functions, since it displays both anticoagulant and procoagulant properties. We have previously reported that beta2GPI can directly bind thrombin, a key serine protease in the coagulation pathway. The present study was undertaken to examine the influence of beta2GPI on thrombin inactivation by the serpin heparin cofactor II (HCII). The effect of anti-beta2GPI antibodies was also examined.HCII inactivation of thrombin was assessed using chromogenic and various platelet functional assays. The influence of intact and proteolytically cleaved beta2GPI and anti-beta2GPI antibodies was determined in these systems.beta2GPI protected thrombin against inactivation by HCII/heparin. Cleavage of beta2GPI at Lys317-Thr318 abrogated its protective effect. Patient polyclonal IgG and murine monoclonal anti-beta2GPI antibodies potentiated the procoagulant influence of beta2GPI in this system.These novel findings suggest that beta2GPI may regulate thrombin inactivation by HCII/heparin. The observation that anti-beta2GPI antibodies potentiate the protective effect of beta2GPI on thrombin in this system, thereby promoting a procoagulant response, may potentially delineate one of the pathophysiologic mechanisms contributing to the prothrombotic tendency in patients with APS." @default.
• W2094872917 created "2016-06-24" @default.
• W2094872917 creator A5000847295 @default.
• W2094872917 creator A5020410868 @default.
• W2094872917 creator A5023534456 @default.
• W2094872917 creator A5037672064 @default.
• W2094872917 creator A5060781990 @default.
• W2094872917 creator A5064603976 @default.
• W2094872917 creator A5068301084 @default.
• W2094872917 date "2008-03-27" @default.
• W2094872917 modified "2023-10-12" @default.
• W2094872917 title "Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: Potentiation of this effect in the presence of anti-β2-glycoprotein I autoantibodies" @default.
• W2094872917 cites W1520470614 @default.
• W2094872917 cites W1556646709 @default.
• W2094872917 cites W1574269074 @default.
• W2094872917 cites W1585291040 @default.
• W2094872917 cites W1921944506 @default.
• W2094872917 cites W1939870037 @default.
• W2094872917 cites W1964476611 @default.
• W2094872917 cites W1974727307 @default.
• W2094872917 cites W1979501351 @default.
• W2094872917 cites W1995342106 @default.
• W2094872917 cites W1998325637 @default.
• W2094872917 cites W1998849190 @default.
• W2094872917 cites W2002600260 @default.
• W2094872917 cites W2005905458 @default.
• W2094872917 cites W2007254026 @default.
• W2094872917 cites W2010012477 @default.
• W2094872917 cites W2014456395 @default.
• W2094872917 cites W2039905764 @default.
• W2094872917 cites W2046838002 @default.
• W2094872917 cites W2047362281 @default.
• W2094872917 cites W2054330426 @default.
• W2094872917 cites W2056894234 @default.
• W2094872917 cites W2059711439 @default.
• W2094872917 cites W2062466582 @default.
• W2094872917 cites W2068600199 @default.
• W2094872917 cites W2074479987 @default.
• W2094872917 cites W2075501249 @default.
• W2094872917 cites W2077094496 @default.
• W2094872917 cites W2094940976 @default.
• W2094872917 cites W2100163592 @default.
• W2094872917 cites W2101831374 @default.
• W2094872917 cites W2111607779 @default.
• W2094872917 cites W2113891001 @default.
• W2094872917 cites W2122450058 @default.
• W2094872917 cites W2133441668 @default.
• W2094872917 cites W2135649522 @default.
• W2094872917 cites W2141930863 @default.
• W2094872917 cites W2142268216 @default.
• W2094872917 cites W2143086319 @default.
• W2094872917 cites W2154400398 @default.
• W2094872917 cites W2162044940 @default.
• W2094872917 cites W2285342383 @default.
• W2094872917 cites W2414195045 @default.
• W2094872917 cites W2418417920 @default.
• W2094872917 cites W4210663131 @default.
• W2094872917 cites W4240067294 @default.
• W2094872917 cites W4298354788 @default.
• W2094872917 cites W4313333858 @default.
• W2094872917 doi "https://doi.org/10.1002/art.23387" @default.
• W2094872917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18383370" @default.
• W2094872917 hasPublicationYear "2008" @default.
• W2094872917 type Work @default.
• W2094872917 sameAs 2094872917 @default.
• W2094872917 citedByCount "23" @default.
• W2094872917 countsByYear W20948729172012 @default.
• W2094872917 countsByYear W20948729172013 @default.
• W2094872917 countsByYear W20948729172014 @default.
• W2094872917 countsByYear W20948729172015 @default.
• W2094872917 countsByYear W20948729172016 @default.
• W2094872917 countsByYear W20948729172017 @default.
• W2094872917 countsByYear W20948729172018 @default.
• W2094872917 countsByYear W20948729172020 @default.
• W2094872917 countsByYear W20948729172021 @default.
• W2094872917 crossrefType "journal-article" @default.
• W2094872917 hasAuthorship W2094872917A5000847295 @default.
• W2094872917 hasAuthorship W2094872917A5020410868 @default.
• W2094872917 hasAuthorship W2094872917A5023534456 @default.
• W2094872917 hasAuthorship W2094872917A5037672064 @default.
• W2094872917 hasAuthorship W2094872917A5060781990 @default.
• W2094872917 hasAuthorship W2094872917A5064603976 @default.
• W2094872917 hasAuthorship W2094872917A5068301084 @default.
• W2094872917 hasConcept C104317684 @default.
• W2094872917 hasConcept C153911025 @default.
• W2094872917 hasConcept C159654299 @default.
• W2094872917 hasConcept C181199279 @default.
• W2094872917 hasConcept C185592680 @default.
• W2094872917 hasConcept C202751555 @default.
• W2094872917 hasConcept C203014093 @default.
• W2094872917 hasConcept C2776714187 @default.
• W2094872917 hasConcept C2777292125 @default.
• W2094872917 hasConcept C2777557582 @default.
• W2094872917 hasConcept C2777807008 @default.
• W2094872917 hasConcept C2778162025 @default.
• W2094872917 hasConcept C2778271848 @default.
• W2094872917 hasConcept C2778965386 @default.
• W2094872917 hasConcept C2779026020 @default.

• next