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- W2094873150 abstract "NK cells attack cells lacking MHC class I, yet MHC class I-deficient mice have normal numbers of NK cells with intact, albeit diminished, functions. Moreover, wild-type NK cells are tolerant of MHC class I-deficient cells in mixed bone marrow chimeras. In this study, we investigated how the absence of MHC class I affects NK cells. NK cells from β<sub>2</sub>-microglobulin-deficient (<i>B2m</i><sup>−/−</sup>) and wild-type mice exhibit similar phenotypic and functional characteristics. Both <i>B2m</i><sup>−/−</sup> and wild-type Ly49H<sup>+</sup> NK cells proliferated robustly and produced IFN-γ after infection with mouse CMV. NK cells in mixed wild-type:<i>B2m</i><sup>−/−</sup> chimeric mice were initially tolerant of MHC class I-deficient host cells. However, this tolerance was gradually lost over time and after mouse CMV infection was rapidly broken, with a pronounced rejection of host <i>B2m</i><sup>−/−</sup> hematopoietic cells. Thus, although NK cells can be held in check against “missing self,” acute inflammation driven by infection can rapidly break established self-tolerance." @default.
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- W2094873150 date "1983-05-01" @default.
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- W2094873150 title "Growth status and the risk of contracting primary tuberculosis." @default.
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- W2094873150 doi "https://doi.org/10.1136/adc.58.5.359" @default.
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