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- W2094877131 abstract "It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice." @default.
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- W2094877131 date "2008-12-01" @default.
- W2094877131 modified "2023-09-24" @default.
- W2094877131 title "Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice" @default.
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- W2094877131 doi "https://doi.org/10.1016/j.ejphar.2008.10.009" @default.
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