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- W2094877885 abstract "Non-suppressible secondary hyperparathyroidism in chronic progressive renal disease.Secondary hyperparathyroidism is a frequent, and almost universal, concomitant of advancing chronic renal disease.When renal failure is of long standing, the degree of secondary hyperparathyroidism may be quite marked.Under such circumstances, short-term elevation of serum calcium concentration does not lead to a decrease in radioimmunoassayable parathyroid hormone to normal levels or to an increase in tubular reabsorption of phosphate (TRP) to normal levels.However, in the majority of patients sustained elevation of serum calcium for periods in excess of two weeks will lead to an increase in TRP to values in excess of 80%.A minority of patients, however, will not respond to phosphate depletion and elevation of serum calcium in the typical manner.Such patients fall into the category of so-called autonomous or tertiary hyperparathyroidism.The present studies demonstrate that patients with non-suppressible or poorly suppressible secondary hyperparathyroidism become readily suppressible following removal of approximately 80% of their parathyroid tissue.That the same tissue present in smaller amounts could be suppressed by a stimulus which had proved ineffectual when the larger mass of gland was present suggests that autonomy may be apparent rather than real and may relate to the mass of the parathyroid hormone secreting tissue present." @default.
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- W2094877885 date "1972-01-01" @default.
- W2094877885 modified "2023-09-27" @default.
- W2094877885 title "Non-suppressible secondary hyperparathyroidism in chronic progressive renal disease" @default.
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- W2094877885 doi "https://doi.org/10.1038/ki.1972.6" @default.
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