FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094890404> ?p ?o ?g. }

• W2094890404 endingPage "16" @default.
• W2094890404 startingPage "1" @default.
• W2094890404 abstract "In this unifying hypothesis directed to the etiology and pathogenesis of atherosclerosis, the importance of focal arterial lesion-prone sites has been emphasized. Key initial participants in these sites include the focal intimal influx and accumulation of low-density lipoprotein (LDL) and a preferential recruitment of blood monocytes. Both are further enhanced in the presence of hyperlipidemia, when the quantity of intimal LDL and the oxidative potential of the intima exceed the capacity of macrophages to remove, via the non-down-regulating scavenger receptor, cytotoxic anionic (Ox-LDL) macromolecules. Foam cells, pathognomonic of the fatty streak, form during the receptor-mediated uptake of Ox-LDL by the macrophages. Interstitial free radicals and the excess of Ox-LDL particles injure and kill cells, including the foam cells, with the formation of the necrotic extracellular lipid core, a key transitional step in lesion progression. Monocyte-macrophage recruitment to the intima is likely to be regulated not only by a multiplicity of endothelial adhesive cytokines, integrins, and selectins, but also by the monocyte-specific chemoattractant, MCP-1, constitutively synthesized and secreted by intimal smooth muscle and endothelial cells. Its synthesis and secretion is augmented by mildly oxidized LDL. Free radicals, pivotal in the oxidation of LDL, and derived from activated macrophages, and also endothelial and smooth muscle cells. Smooth muscle cells migrate from the media through the intimal endothelial layer (IEL) and proliferate under the regulation of a number of mitogens, including platelet-derived growth factor (PDGF). Collagen synthesis by smooth muscle cells is substantial. Lymphocytes, as a source of interferons, invade the plaque and are present in the adventitia in substantial numbers, likely representing an autoimmune response in the later stages of plaque development. Platelets and mural thrombosis directly contribute to subsequent plaque growth, particularly after plaque rupture or fissure and disruption of the thrombo-resistant endothelial cells (EC). Plaque regression in all likelihood involves the conversion of the inert pool of extracellular lipid to a metabolically active intracellular pool and subsequent clearance by the high-density lipoprotein mediated reverse cholesterol transport system. The atherogenic cascades so described conceptually represent arterial inflammatory and healing processes occurring in a hyperlipidemic environment. Many components of pathogenesis are the targets for modulation by genetic, hemodynamic and selected risk factors. The prevention and treatment of the disease should logically target reduction in plasma LDL levels, the inhibition of the oxidative modification of lipoproteins, including LDL, by free radical scavengers, and augmentation of the reverse cholesterol transport system." @default.
• W2094890404 created "2016-06-24" @default.
• W2094890404 creator A5034515720 @default.
• W2094890404 creator A5055819112 @default.
• W2094890404 creator A5064279421 @default.
• W2094890404 creator A5073419719 @default.
• W2094890404 creator A5090468990 @default.
• W2094890404 date "1991-02-01" @default.
• W2094890404 modified "2023-10-16" @default.
• W2094890404 title "The pathogenesis of atherosclerosis: An overview" @default.
• W2094890404 cites W122471107 @default.
• W2094890404 cites W1497622633 @default.
• W2094890404 cites W1531305061 @default.
• W2094890404 cites W1546909579 @default.
• W2094890404 cites W1547338001 @default.
• W2094890404 cites W1578027966 @default.
• W2094890404 cites W1578600946 @default.
• W2094890404 cites W1583489560 @default.
• W2094890404 cites W1638048546 @default.
• W2094890404 cites W1871621847 @default.
• W2094890404 cites W1945199177 @default.
• W2094890404 cites W1964752630 @default.
• W2094890404 cites W1968679020 @default.
• W2094890404 cites W1969413677 @default.
• W2094890404 cites W1972334156 @default.
• W2094890404 cites W1975342147 @default.
• W2094890404 cites W1976800433 @default.
• W2094890404 cites W1977778060 @default.
• W2094890404 cites W1994360551 @default.
• W2094890404 cites W1994801308 @default.
• W2094890404 cites W1996309481 @default.
• W2094890404 cites W1996570657 @default.
• W2094890404 cites W1999083451 @default.
• W2094890404 cites W1999520846 @default.
• W2094890404 cites W2000377675 @default.
• W2094890404 cites W2000548860 @default.
• W2094890404 cites W2001132215 @default.
• W2094890404 cites W2005230846 @default.
• W2094890404 cites W2005910570 @default.
• W2094890404 cites W2008819827 @default.
• W2094890404 cites W2011494513 @default.
• W2094890404 cites W2011785451 @default.
• W2094890404 cites W2021412823 @default.
• W2094890404 cites W2028916006 @default.
• W2094890404 cites W2030720809 @default.
• W2094890404 cites W2036852690 @default.
• W2094890404 cites W2037599912 @default.
• W2094890404 cites W2038484123 @default.
• W2094890404 cites W2040536713 @default.
• W2094890404 cites W2040579726 @default.
• W2094890404 cites W2042819132 @default.
• W2094890404 cites W2048250248 @default.
• W2094890404 cites W2048954947 @default.
• W2094890404 cites W2049401036 @default.
• W2094890404 cites W2050033263 @default.
• W2094890404 cites W2056481007 @default.
• W2094890404 cites W2057190622 @default.
• W2094890404 cites W2058773932 @default.
• W2094890404 cites W2059960157 @default.
• W2094890404 cites W2061755142 @default.
• W2094890404 cites W2063813098 @default.
• W2094890404 cites W2064179373 @default.
• W2094890404 cites W2065591461 @default.
• W2094890404 cites W2065964038 @default.
• W2094890404 cites W2066603840 @default.
• W2094890404 cites W2068925035 @default.
• W2094890404 cites W2070951814 @default.
• W2094890404 cites W2071328111 @default.
• W2094890404 cites W2072745706 @default.
• W2094890404 cites W2073737700 @default.
• W2094890404 cites W2074632434 @default.
• W2094890404 cites W2076451751 @default.
• W2094890404 cites W2076588706 @default.
• W2094890404 cites W2078915564 @default.
• W2094890404 cites W2080993700 @default.
• W2094890404 cites W2082494120 @default.
• W2094890404 cites W2084073097 @default.
• W2094890404 cites W2086230745 @default.
• W2094890404 cites W2086231394 @default.
• W2094890404 cites W2091562229 @default.
• W2094890404 cites W2093927588 @default.
• W2094890404 cites W2103342908 @default.
• W2094890404 cites W2104573407 @default.
• W2094890404 cites W2113504642 @default.
• W2094890404 cites W2117774408 @default.
• W2094890404 cites W2120344355 @default.
• W2094890404 cites W2127696028 @default.
• W2094890404 cites W2136057441 @default.
• W2094890404 cites W2137703092 @default.
• W2094890404 cites W2140193538 @default.
• W2094890404 cites W2145799136 @default.
• W2094890404 cites W2148371225 @default.
• W2094890404 cites W2162458714 @default.
• W2094890404 cites W2165773709 @default.
• W2094890404 cites W2216300142 @default.
• W2094890404 cites W2316453626 @default.
• W2094890404 cites W2317358310 @default.
• W2094890404 cites W38858686 @default.

• next