FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094892629> ?p ?o ?g. }

• W2094892629 endingPage "11706" @default.
• W2094892629 startingPage "11700" @default.
• W2094892629 abstract "The membranous labyrinth of the inner ear establishes a precise geometrical topology so that it may subserve the functions of hearing and balance. How this geometry arises from a simple ectodermal placode is under active investigation. The placode invaginates to form the otic cup, which deepens before pinching off to form the otic vesicle. By the vesicle stage many genes expressed in the developing ear have assumed broad, asymmetrical expression domains. We have been exploring the possibility that these domains may reflect developmental compartments that are instrumental in specifying the location and identity of different parts of the ear. The boundaries between compartments are proposed to be the site of inductive interactions required for this specification. Our work has shown that sensory organs and the endolymphatic duct each arise near the boundaries of broader gene expression domains, lending support to this idea. A further prediction of the model, that the compartment boundaries will also represent lineage-restriction compartments, is supported in part by fate mapping the otic cup. Our data suggest that two lineage-restriction boundaries intersect at the dorsal pole of the otocyst, a convergence that may be critical for the specification of endolymphatic duct outgrowth. We speculate that the patterning information necessary to establish these two orthogonal boundaries may emanate, in part, from the hindbrain. The compartment boundary model of ear development now needs to be tested through a variety of experimental perturbations, such as the removal of boundaries, the generation of ectopic boundaries, and/or changes in compartment identity." @default.
• W2094892629 created "2016-06-24" @default.
• W2094892629 creator A5003932847 @default.
• W2094892629 creator A5023969163 @default.
• W2094892629 creator A5055156340 @default.
• W2094892629 creator A5063753662 @default.
• W2094892629 creator A5068382420 @default.
• W2094892629 date "2000-10-24" @default.
• W2094892629 modified "2023-09-24" @default.
• W2094892629 title "Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?" @default.
• W2094892629 cites W1487878476 @default.
• W2094892629 cites W149600209 @default.
• W2094892629 cites W1527331090 @default.
• W2094892629 cites W1601043516 @default.
• W2094892629 cites W1822449379 @default.
• W2094892629 cites W1852660910 @default.
• W2094892629 cites W1881443426 @default.
• W2094892629 cites W1910819802 @default.
• W2094892629 cites W1919390978 @default.
• W2094892629 cites W1936954588 @default.
• W2094892629 cites W1939766922 @default.
• W2094892629 cites W1964009055 @default.
• W2094892629 cites W1976053867 @default.
• W2094892629 cites W1978272861 @default.
• W2094892629 cites W1981544525 @default.
• W2094892629 cites W1983066989 @default.
• W2094892629 cites W1983954230 @default.
• W2094892629 cites W1988744516 @default.
• W2094892629 cites W2000646745 @default.
• W2094892629 cites W2006666611 @default.
• W2094892629 cites W2015799439 @default.
• W2094892629 cites W2017873922 @default.
• W2094892629 cites W2019943259 @default.
• W2094892629 cites W2024435992 @default.
• W2094892629 cites W2024635756 @default.
• W2094892629 cites W2027169221 @default.
• W2094892629 cites W2031842041 @default.
• W2094892629 cites W2038894508 @default.
• W2094892629 cites W2052895234 @default.
• W2094892629 cites W2053609696 @default.
• W2094892629 cites W2053700844 @default.
• W2094892629 cites W2054429098 @default.
• W2094892629 cites W2064963621 @default.
• W2094892629 cites W2068796796 @default.
• W2094892629 cites W2071517371 @default.
• W2094892629 cites W2072493946 @default.
• W2094892629 cites W2073498126 @default.
• W2094892629 cites W2080493586 @default.
• W2094892629 cites W2081748379 @default.
• W2094892629 cites W2086972110 @default.
• W2094892629 cites W2088535127 @default.
• W2094892629 cites W2097894273 @default.
• W2094892629 cites W2102428207 @default.
• W2094892629 cites W2102565376 @default.
• W2094892629 cites W2123396085 @default.
• W2094892629 cites W2125246072 @default.
• W2094892629 cites W2126122570 @default.
• W2094892629 cites W2129589628 @default.
• W2094892629 cites W2131929240 @default.
• W2094892629 cites W2135144225 @default.
• W2094892629 cites W2139722243 @default.
• W2094892629 cites W2150120961 @default.
• W2094892629 cites W2154279879 @default.
• W2094892629 cites W2169861463 @default.
• W2094892629 cites W2182697631 @default.
• W2094892629 cites W2184559181 @default.
• W2094892629 cites W2188932417 @default.
• W2094892629 cites W2431267004 @default.
• W2094892629 cites W4236770317 @default.
• W2094892629 cites W9842050 @default.
• W2094892629 doi "https://doi.org/10.1073/pnas.97.22.11700" @default.
• W2094892629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/34338" @default.
• W2094892629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11050198" @default.
• W2094892629 hasPublicationYear "2000" @default.
• W2094892629 type Work @default.
• W2094892629 sameAs 2094892629 @default.
• W2094892629 citedByCount "113" @default.
• W2094892629 countsByYear W20948926292012 @default.
• W2094892629 countsByYear W20948926292013 @default.
• W2094892629 countsByYear W20948926292014 @default.
• W2094892629 countsByYear W20948926292015 @default.
• W2094892629 countsByYear W20948926292016 @default.
• W2094892629 countsByYear W20948926292017 @default.
• W2094892629 countsByYear W20948926292018 @default.
• W2094892629 countsByYear W20948926292019 @default.
• W2094892629 countsByYear W20948926292020 @default.
• W2094892629 countsByYear W20948926292021 @default.
• W2094892629 countsByYear W20948926292022 @default.
• W2094892629 countsByYear W20948926292023 @default.
• W2094892629 crossrefType "journal-article" @default.
• W2094892629 hasAuthorship W2094892629A5003932847 @default.
• W2094892629 hasAuthorship W2094892629A5023969163 @default.
• W2094892629 hasAuthorship W2094892629A5055156340 @default.
• W2094892629 hasAuthorship W2094892629A5063753662 @default.
• W2094892629 hasAuthorship W2094892629A5068382420 @default.
• W2094892629 hasBestOaLocation W20948926292 @default.
• W2094892629 hasConcept C104317684 @default.
• W2094892629 hasConcept C105702510 @default.

• next