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- W2094902012 abstract "The biological effects of DNA‐damaging agents are codetermined by the structural characteristics of the lesions, the quality and extent of the local distortion of DNA and chromatin structure, and the mode(s) of damage processing used by a given type of cell. Persistent damage (i.e., damage that is not removed before it is reached by DNA replication) may be mostly responsible for metagenesis and carcinogenesis. To understand the effects of environmental physical and chemical DNA‐damaging agents on human health, the mechanisms of damage processing used by human cells have to be elucidated. We report our studies of the excision of gamma‐ray products of the 5,6‐dihydroxydihydrothymine type (tγ o2) in normal human fibroblasts and in fibroblasts from patients with the hereditary diseases Fanconi's anemia (FA) and ataxia telangiectasia (AT). Both diseases are characterized by chromosomal instability and increased susceptibility for the development of cancer. Decreased capacities of nuclear and whole cell sonicat..." @default.
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- W2094902012 date "1977-07-01" @default.
- W2094902012 modified "2023-10-18" @default.
- W2094902012 title "Repair of DNA damage induced by ionizing radiation and benzo[α]pyrene in mammalian cells" @default.
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- W2094902012 doi "https://doi.org/10.1080/15287397709529537" @default.
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