FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094902392> ?p ?o ?g. }

• W2094902392 abstract "The Na(+)/K(+)-ATPase inhibitor ouabain has been shown to trigger hypertrophic growth of cultured cardiomyocytes; however, the significance of endogenous ouabain-like compound (OLC) in the hypertrophic process in vivo is unknown. Here we characterized the involvement of OLC in left ventricular (LV) hypertrophy induced by norepinephrine (NE) and angiotensin II (Ang II) infusions in rats. Administration of NE (300 microg/kg/h) via subcutanously implanted osmotic minipumps for 72 h resulted in a significant increase in left ventricular weight to body weight (LVW/BW) ratio (P<0.001) and a substantial up-regulation of atrial natriuretic peptide (ANP) gene expression (13.2-fold, P<0.001). NE infusion induced a transient increase in plasma OLC levels at 12 h (P<0.05), which returned to control levels by 72 h. Adrenalectomy markedly reduced both basal and NE-induced increase in plasma OLC levels. LVW/BW ratio was not modulated by adrenalectomy; however, ANP gene expression was blunted by 44% (P<0.01) and 47% (P<0.05) at 12 and 72 h, respectively. In agreement, adrenalectomy reduced up-regulation of ANP without affecting LV mass in rats infused with Ang II (33 microg/kg/h). Administration of exogenous ouabain (1 nM to 100 microM) for 24 h had no effect on ANP gene expression in cultured neonatal rat ventricular myocytes. However, the up-regulation of ANP mRNA levels induced by the alpha-adrenergic agonist phenylephrine (1 microM) was markedly enhanced by ouabain (100 microM) (5.6-fold vs. 9.6-fold, P<0.01). These data show that OLC as an adrenal-derived factor may be required for the induction LV ANP gene expression during the hypertrophic process." @default.
• W2094902392 created "2016-06-24" @default.
• W2094902392 creator A5010201455 @default.
• W2094902392 creator A5011122165 @default.
• W2094902392 creator A5018593288 @default.
• W2094902392 creator A5020102435 @default.
• W2094902392 creator A5021612103 @default.
• W2094902392 creator A5027435870 @default.
• W2094902392 creator A5033605795 @default.
• W2094902392 creator A5036012653 @default.
• W2094902392 creator A5036810318 @default.
• W2094902392 creator A5051431561 @default.
• W2094902392 creator A5059562776 @default.
• W2094902392 creator A5063619700 @default.
• W2094902392 creator A5069650608 @default.
• W2094902392 creator A5089869480 @default.
• W2094902392 date "2007-03-01" @default.
• W2094902392 modified "2023-10-18" @default.
• W2094902392 title "Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo" @default.
• W2094902392 cites W1576990557 @default.
• W2094902392 cites W1970128059 @default.
• W2094902392 cites W1970260922 @default.
• W2094902392 cites W1976293393 @default.
• W2094902392 cites W1982240282 @default.
• W2094902392 cites W1983692570 @default.
• W2094902392 cites W1984687894 @default.
• W2094902392 cites W1987534461 @default.
• W2094902392 cites W1993679911 @default.
• W2094902392 cites W1997819382 @default.
• W2094902392 cites W1998496847 @default.
• W2094902392 cites W2000793858 @default.
• W2094902392 cites W2000903823 @default.
• W2094902392 cites W2003014497 @default.
• W2094902392 cites W2006310369 @default.
• W2094902392 cites W2009678908 @default.
• W2094902392 cites W2011780678 @default.
• W2094902392 cites W2018615073 @default.
• W2094902392 cites W2020159458 @default.
• W2094902392 cites W2020285672 @default.
• W2094902392 cites W2042509109 @default.
• W2094902392 cites W2049414505 @default.
• W2094902392 cites W2050728158 @default.
• W2094902392 cites W2051893563 @default.
• W2094902392 cites W2060333964 @default.
• W2094902392 cites W2071443658 @default.
• W2094902392 cites W2071762197 @default.
• W2094902392 cites W2081874034 @default.
• W2094902392 cites W2082110280 @default.
• W2094902392 cites W2082779145 @default.
• W2094902392 cites W2082937244 @default.
• W2094902392 cites W2084921078 @default.
• W2094902392 cites W2086041680 @default.
• W2094902392 cites W2086449586 @default.
• W2094902392 cites W2086858222 @default.
• W2094902392 cites W2106798873 @default.
• W2094902392 cites W2116153685 @default.
• W2094902392 cites W2116947619 @default.
• W2094902392 cites W2117490534 @default.
• W2094902392 cites W2121034044 @default.
• W2094902392 cites W2121508606 @default.
• W2094902392 cites W2122686025 @default.
• W2094902392 cites W2124403636 @default.
• W2094902392 cites W2129439677 @default.
• W2094902392 cites W2130678592 @default.
• W2094902392 cites W2132595000 @default.
• W2094902392 cites W2133578307 @default.
• W2094902392 cites W2159830700 @default.
• W2094902392 cites W2161018612 @default.
• W2094902392 cites W2162040432 @default.
• W2094902392 cites W2182245524 @default.
• W2094902392 cites W2334499091 @default.
• W2094902392 cites W4235521596 @default.
• W2094902392 cites W4245668540 @default.
• W2094902392 doi "https://doi.org/10.1016/j.lfs.2006.12.026" @default.
• W2094902392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17266992" @default.
• W2094902392 hasPublicationYear "2007" @default.
• W2094902392 type Work @default.
• W2094902392 sameAs 2094902392 @default.
• W2094902392 citedByCount "16" @default.
• W2094902392 countsByYear W20949023922012 @default.
• W2094902392 countsByYear W20949023922013 @default.
• W2094902392 countsByYear W20949023922017 @default.
• W2094902392 countsByYear W20949023922020 @default.
• W2094902392 countsByYear W20949023922021 @default.
• W2094902392 countsByYear W20949023922023 @default.
• W2094902392 crossrefType "journal-article" @default.
• W2094902392 hasAuthorship W2094902392A5010201455 @default.
• W2094902392 hasAuthorship W2094902392A5011122165 @default.
• W2094902392 hasAuthorship W2094902392A5018593288 @default.
• W2094902392 hasAuthorship W2094902392A5020102435 @default.
• W2094902392 hasAuthorship W2094902392A5021612103 @default.
• W2094902392 hasAuthorship W2094902392A5027435870 @default.
• W2094902392 hasAuthorship W2094902392A5033605795 @default.
• W2094902392 hasAuthorship W2094902392A5036012653 @default.
• W2094902392 hasAuthorship W2094902392A5036810318 @default.
• W2094902392 hasAuthorship W2094902392A5051431561 @default.
• W2094902392 hasAuthorship W2094902392A5059562776 @default.
• W2094902392 hasAuthorship W2094902392A5063619700 @default.
• W2094902392 hasAuthorship W2094902392A5069650608 @default.
• W2094902392 hasAuthorship W2094902392A5089869480 @default.

• next