Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094904848> ?p ?o ?g. }
- W2094904848 endingPage "2086" @default.
- W2094904848 startingPage "2081" @default.
- W2094904848 abstract "The human cytomegalovirus UL99-coded pp28 is a myristoylated phosphoprotein located in the virion tegument domain, which resides between the capsid and envelope. A previous study has demonstrated that BAD sub UL99, a pp28-deficient mutant virus, fails to assemble enveloped virus particles. Capsids, coated with tegument proteins, accumulate in the cytoplasm of mutant virus-infected cells. This phenotype indicates that pp28 is required for the acquisition of an envelope; it presumably acts by directing tegument-associated capsids to bud through an intracellular membrane derived from the cell's secretory apparatus that has been modified to contain viral transmembrane glycoproteins. Here we demonstrate that BAD sub UL99 can spread from cell to cell, even though highly sensitive assays fail to detect infectious virus progeny in cultures of infected fibroblasts. We propose that, in the absence of pp28, tegument-coated capsids might nevertheless bud through cellular membranes, including the plasma membrane. If this suggestion is correct, the enveloped particle could potentially infect an adjacent cell to mediate the cell-to-cell spread that is observed. This mode of spread might also occur after infection with wild-type virus, and it could facilitate immune evasion, assuming that the resulting particles do not have a normal complement of virus-coded envelope glycoproteins." @default.
- W2094904848 created "2016-06-24" @default.
- W2094904848 creator A5000668079 @default.
- W2094904848 creator A5056057404 @default.
- W2094904848 creator A5065208376 @default.
- W2094904848 date "2005-01-31" @default.
- W2094904848 modified "2023-09-27" @default.
- W2094904848 title "Human cytomegalovirus cell-to-cell spread in the absence of an essential assembly protein" @default.
- W2094904848 cites W1508127078 @default.
- W2094904848 cites W1513464990 @default.
- W2094904848 cites W1519702874 @default.
- W2094904848 cites W1523497932 @default.
- W2094904848 cites W1539619662 @default.
- W2094904848 cites W1546496433 @default.
- W2094904848 cites W1608297032 @default.
- W2094904848 cites W1614146403 @default.
- W2094904848 cites W1746954312 @default.
- W2094904848 cites W1922854624 @default.
- W2094904848 cites W1964781173 @default.
- W2094904848 cites W1977225005 @default.
- W2094904848 cites W1980343850 @default.
- W2094904848 cites W1980647075 @default.
- W2094904848 cites W2001465532 @default.
- W2094904848 cites W2003434242 @default.
- W2094904848 cites W2014567309 @default.
- W2094904848 cites W201594725 @default.
- W2094904848 cites W2029987769 @default.
- W2094904848 cites W2043522420 @default.
- W2094904848 cites W2060583702 @default.
- W2094904848 cites W2061757869 @default.
- W2094904848 cites W2066956738 @default.
- W2094904848 cites W2069023071 @default.
- W2094904848 cites W2082773355 @default.
- W2094904848 cites W2110712815 @default.
- W2094904848 cites W2114858538 @default.
- W2094904848 cites W2122933800 @default.
- W2094904848 cites W2123193533 @default.
- W2094904848 cites W2124669617 @default.
- W2094904848 cites W2137526395 @default.
- W2094904848 cites W2139482242 @default.
- W2094904848 cites W2142404794 @default.
- W2094904848 cites W2148382823 @default.
- W2094904848 cites W2153924587 @default.
- W2094904848 cites W2163409698 @default.
- W2094904848 cites W2163805059 @default.
- W2094904848 cites W2170308653 @default.
- W2094904848 cites W2171983197 @default.
- W2094904848 doi "https://doi.org/10.1073/pnas.0409597102" @default.
- W2094904848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/548577" @default.
- W2094904848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15684067" @default.
- W2094904848 hasPublicationYear "2005" @default.
- W2094904848 type Work @default.
- W2094904848 sameAs 2094904848 @default.
- W2094904848 citedByCount "65" @default.
- W2094904848 countsByYear W20949048482013 @default.
- W2094904848 countsByYear W20949048482014 @default.
- W2094904848 countsByYear W20949048482016 @default.
- W2094904848 countsByYear W20949048482017 @default.
- W2094904848 countsByYear W20949048482018 @default.
- W2094904848 countsByYear W20949048482019 @default.
- W2094904848 countsByYear W20949048482020 @default.
- W2094904848 countsByYear W20949048482021 @default.
- W2094904848 countsByYear W20949048482022 @default.
- W2094904848 countsByYear W20949048482023 @default.
- W2094904848 crossrefType "journal-article" @default.
- W2094904848 hasAuthorship W2094904848A5000668079 @default.
- W2094904848 hasAuthorship W2094904848A5056057404 @default.
- W2094904848 hasAuthorship W2094904848A5065208376 @default.
- W2094904848 hasBestOaLocation W20949048482 @default.
- W2094904848 hasConcept C108625454 @default.
- W2094904848 hasConcept C140704245 @default.
- W2094904848 hasConcept C146998594 @default.
- W2094904848 hasConcept C1491633281 @default.
- W2094904848 hasConcept C153911025 @default.
- W2094904848 hasConcept C159047783 @default.
- W2094904848 hasConcept C190062978 @default.
- W2094904848 hasConcept C202878990 @default.
- W2094904848 hasConcept C2522874641 @default.
- W2094904848 hasConcept C2909404852 @default.
- W2094904848 hasConcept C40479148 @default.
- W2094904848 hasConcept C55493867 @default.
- W2094904848 hasConcept C58475186 @default.
- W2094904848 hasConcept C86803240 @default.
- W2094904848 hasConcept C92488253 @default.
- W2094904848 hasConcept C95444343 @default.
- W2094904848 hasConcept C97380033 @default.
- W2094904848 hasConceptScore W2094904848C108625454 @default.
- W2094904848 hasConceptScore W2094904848C140704245 @default.
- W2094904848 hasConceptScore W2094904848C146998594 @default.
- W2094904848 hasConceptScore W2094904848C1491633281 @default.
- W2094904848 hasConceptScore W2094904848C153911025 @default.
- W2094904848 hasConceptScore W2094904848C159047783 @default.
- W2094904848 hasConceptScore W2094904848C190062978 @default.
- W2094904848 hasConceptScore W2094904848C202878990 @default.
- W2094904848 hasConceptScore W2094904848C2522874641 @default.
- W2094904848 hasConceptScore W2094904848C2909404852 @default.
- W2094904848 hasConceptScore W2094904848C40479148 @default.
- W2094904848 hasConceptScore W2094904848C55493867 @default.