FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094906472> ?p ?o ?g. }

• W2094906472 endingPage "796" @default.
• W2094906472 startingPage "792" @default.
• W2094906472 abstract "Treatment with anti-estrogens or aromatase inhibitors (AI) is the main therapeutic strategy used against estrogen receptor ERα-positive breast cancer. Resistance to these therapies presents a major challenge in the management of breast cancer. Little is known about ERβ in breast carcinogenesis. Our aim in this study is to examine potential novel strategies utilizing ERβ activity to overcome AI resistance. We provide evidence that ERβ agonist can reduce the growth of AI-resistant breast cancer cells. Our data further confirm that therapeutic activation of ERβ by DPN, an ERβ agonist, blocks letrozole-resistant tumor growth in a xenograft model. Interestingly, DPN exerted tumor growth inhibition only in the presence of the AI letrozole, suggesting that combination therapy including ERβ activators and AI may be used in the clinical setting treating AI resistant breast cancer. An increase in ERβ levels, with diminished ERα/ERβ ratio, was observed in the tumors from mice treated with DPN/letrozole combination compared to single agents and control. Decreased Cyclin D1 and increased CyclinD1/CDK inhibitors p21 and p27 levels in DPN/letrozole treated tumors were observed, suggesting that the combination treatment may inhibit tumor growth by blocking G1/S phase cell cycle progression. Our data show a decrease in MAPK phosphorylation levels without affecting total levels. In addition to providing evidence suggesting the potential use of ERβ agonists in combination with letrozole in treating AI resistant breast cancer and prolonging sensitivity to AI, we also provide mechanistic evidence supporting the role of ERβ in altering the expression profile associated with resistance." @default.
• W2094906472 created "2016-06-24" @default.
• W2094906472 creator A5010406195 @default.
• W2094906472 creator A5025974251 @default.
• W2094906472 creator A5031605337 @default.
• W2094906472 creator A5054763940 @default.
• W2094906472 creator A5090010000 @default.
• W2094906472 date "2011-07-01" @default.
• W2094906472 modified "2023-09-26" @default.
• W2094906472 title "Estrogen receptor-β activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy" @default.
• W2094906472 cites W1494693924 @default.
• W2094906472 cites W1965701270 @default.
• W2094906472 cites W1969070090 @default.
• W2094906472 cites W1979374580 @default.
• W2094906472 cites W1991638932 @default.
• W2094906472 cites W1999312756 @default.
• W2094906472 cites W2011925462 @default.
• W2094906472 cites W2014584008 @default.
• W2094906472 cites W2017886735 @default.
• W2094906472 cites W2018552063 @default.
• W2094906472 cites W2027570854 @default.
• W2094906472 cites W2029521041 @default.
• W2094906472 cites W2046484711 @default.
• W2094906472 cites W2077448555 @default.
• W2094906472 cites W2092411075 @default.
• W2094906472 cites W2106181427 @default.
• W2094906472 cites W2121048892 @default.
• W2094906472 cites W2127603929 @default.
• W2094906472 cites W2127654933 @default.
• W2094906472 cites W2133010239 @default.
• W2094906472 cites W2141232624 @default.
• W2094906472 cites W2155225555 @default.
• W2094906472 cites W2164609052 @default.
• W2094906472 cites W2166766053 @default.
• W2094906472 cites W4245711986 @default.
• W2094906472 cites W4247105274 @default.
• W2094906472 doi "https://doi.org/10.1016/j.steroids.2011.02.038" @default.
• W2094906472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21477609" @default.
• W2094906472 hasPublicationYear "2011" @default.
• W2094906472 type Work @default.
• W2094906472 sameAs 2094906472 @default.
• W2094906472 citedByCount "19" @default.
• W2094906472 countsByYear W20949064722012 @default.
• W2094906472 countsByYear W20949064722013 @default.
• W2094906472 countsByYear W20949064722014 @default.
• W2094906472 countsByYear W20949064722015 @default.
• W2094906472 countsByYear W20949064722016 @default.
• W2094906472 countsByYear W20949064722017 @default.
• W2094906472 countsByYear W20949064722020 @default.
• W2094906472 countsByYear W20949064722023 @default.
• W2094906472 crossrefType "journal-article" @default.
• W2094906472 hasAuthorship W2094906472A5010406195 @default.
• W2094906472 hasAuthorship W2094906472A5025974251 @default.
• W2094906472 hasAuthorship W2094906472A5031605337 @default.
• W2094906472 hasAuthorship W2094906472A5054763940 @default.
• W2094906472 hasAuthorship W2094906472A5090010000 @default.
• W2094906472 hasConcept C121608353 @default.
• W2094906472 hasConcept C126322002 @default.
• W2094906472 hasConcept C134018914 @default.
• W2094906472 hasConcept C170493617 @default.
• W2094906472 hasConcept C184235292 @default.
• W2094906472 hasConcept C185592680 @default.
• W2094906472 hasConcept C199835354 @default.
• W2094906472 hasConcept C2776166826 @default.
• W2094906472 hasConcept C2776999253 @default.
• W2094906472 hasConcept C2778504769 @default.
• W2094906472 hasConcept C2778812593 @default.
• W2094906472 hasConcept C2778938600 @default.
• W2094906472 hasConcept C2780482068 @default.
• W2094906472 hasConcept C29537977 @default.
• W2094906472 hasConcept C502942594 @default.
• W2094906472 hasConcept C530470458 @default.
• W2094906472 hasConcept C55493867 @default.
• W2094906472 hasConcept C57074206 @default.
• W2094906472 hasConcept C71924100 @default.
• W2094906472 hasConcept C84606932 @default.
• W2094906472 hasConcept C98274493 @default.
• W2094906472 hasConceptScore W2094906472C121608353 @default.
• W2094906472 hasConceptScore W2094906472C126322002 @default.
• W2094906472 hasConceptScore W2094906472C134018914 @default.
• W2094906472 hasConceptScore W2094906472C170493617 @default.
• W2094906472 hasConceptScore W2094906472C184235292 @default.
• W2094906472 hasConceptScore W2094906472C185592680 @default.
• W2094906472 hasConceptScore W2094906472C199835354 @default.
• W2094906472 hasConceptScore W2094906472C2776166826 @default.
• W2094906472 hasConceptScore W2094906472C2776999253 @default.
• W2094906472 hasConceptScore W2094906472C2778504769 @default.
• W2094906472 hasConceptScore W2094906472C2778812593 @default.
• W2094906472 hasConceptScore W2094906472C2778938600 @default.
• W2094906472 hasConceptScore W2094906472C2780482068 @default.
• W2094906472 hasConceptScore W2094906472C29537977 @default.
• W2094906472 hasConceptScore W2094906472C502942594 @default.
• W2094906472 hasConceptScore W2094906472C530470458 @default.
• W2094906472 hasConceptScore W2094906472C55493867 @default.
• W2094906472 hasConceptScore W2094906472C57074206 @default.
• W2094906472 hasConceptScore W2094906472C71924100 @default.
• W2094906472 hasConceptScore W2094906472C84606932 @default.
• W2094906472 hasConceptScore W2094906472C98274493 @default.

• next