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- W2094937078 startingPage "e15780" @default.
- W2094937078 abstract "Insulin-like peptides (ILPs) regulate growth, reproduction, metabolic homeostasis, life span and stress resistance in worms, flies and mammals. A set of insulin producing cells (IPCs) in the Drosophila brain that express three ILPs (DILP2, 3 and 5) have been the main focus of interest in hormonal DILP signaling. Little is, however, known about factors that regulate DILP production and release by these IPCs. Here we show that the IPCs express the metabotropic GABAB receptor (GBR), but not the ionotropic GABAA receptor subunit RDL. Diminishing the GBR expression on these cells by targeted RNA interference abbreviates life span, decreases metabolic stress resistance and alters carbohydrate and lipid metabolism at stress, but not growth in Drosophila. A direct effect of diminishing GBR on IPCs is an increase in DILP immunofluorescence in these cells, an effect that is accentuated at starvation. Knockdown of irk3, possibly part of a G protein-activated inwardly rectifying K+ channel that may link to GBRs, phenocopies GBR knockdown in starvation experiments. Our experiments suggest that the GBR is involved in inhibitory control of DILP production and release in adult flies at metabolic stress and that this receptor mediates a GABA signal from brain interneurons that may convey nutritional signals. This is the first demonstration of a neurotransmitter that inhibits insulin signaling in its regulation of metabolism, stress and life span in an invertebrate brain." @default.
- W2094937078 created "2016-06-24" @default.
- W2094937078 creator A5000832298 @default.
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- W2094937078 creator A5016075960 @default.
- W2094937078 creator A5073366463 @default.
- W2094937078 date "2010-12-30" @default.
- W2094937078 modified "2023-09-27" @default.
- W2094937078 title "Insulin Signaling, Lifespan and Stress Resistance Are Modulated by Metabotropic GABA Receptors on Insulin Producing Cells in the Brain of Drosophila" @default.
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- W2094937078 doi "https://doi.org/10.1371/journal.pone.0015780" @default.
- W2094937078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3012717" @default.
- W2094937078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209905" @default.
- W2094937078 hasPublicationYear "2010" @default.
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