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• W2094939958 abstract "Abstract Objectives: Lung cancer is the leading cause of cancer mortality in the United States and worldwide, and Wnt signaling pathway abnormalities have been implicated in its development. We planned to study the expression of Naked cuticle 2 (Nkd2), a Wnt signaling pathway antagonist, in lung adenocarcinoma tissue specimens. Methods: Two hundred patients with lung adenocarcinoma underwent surgical resection. Tumor and adjacent normal specimens were collected at the time of the procedure and stored in liquid nitrogen until analysis. Clinical data, including patient age, sex, vital status, smoking status, as well as tumor histology and stage, were obtained by review of electronic medical records. RNA was extracted using the Qiagen RNeasy Mini Kit, and cDNA was synthesized using the Bio-Rad iScript Kit. Nkd2 expression was measured using a microarray in 110 patients and quantitative polymerase chain reaction (qPCR) in 90 patients. We looked for differences in Nkd2 expression between patients of different sex, histologic subtype, or vital status; and among patients with different smoking status or stage. We described the distribution of Nkd2 expression in both the microarray and qPCR cohorts. We analyzed the relation between Nkd2 expression and survival using the Kaplan-Meier method and a Cox proportional hazards model. Results: There was no difference in Nkd2 expression between patients of different sex, histologic subtype, or vital status; nor among patients with different smoking status or stage. Nkd2 expression in the tumor was upregulated in the microarray cohort, but downregulated in the qpCR cohort, compared to the adjacent normal. In the microarray cohort, Nkd2 expression was not significantly related to survival (p=0.71). In the qPCR cohort, after adjusting for age, sex, smoking status, bronchoalveolar carcinoma status, and stage, lower Nkd2 expression was significantly associated with longer survival (p=0.03). Stage was the only other significant predictor of survival (Wald test, p = 0.0002). Conclusion: In one cohort in our study, lower Nkd2 expression was significantly associated with longer survival. It is unclear why lower expression of Wnt signaling pathway antagonist would be associated with longer survival, when higher Wnt signaling has been associated with carcinogenesis. One hypothesis is that there is a negative feedback mechanism, in which upregulation of Wnt signaling leads to upregulation of Nkd2. Molecular markers have a growing role in cancer research, and further studies on Nkd2 may lead to new diagnostic and therapeutic applications. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B183." @default.
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• W2094939958 date "2011-11-01" @default.
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• W2094939958 title "Abstract B183: Nkd2 expression and survival in lung adenocarcinoma." @default.
• W2094939958 doi "https://doi.org/10.1158/1535-7163.targ-11-b183" @default.
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