FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094941393> ?p ?o ?g. }

• W2094941393 endingPage "126" @default.
• W2094941393 startingPage "118" @default.
• W2094941393 abstract "Background: We have previously reported that, in addition to modifying IgG levels and subclass distributions, wasp venom immunotherapy (VIT) rapidly changes IgG antibody specificity.Objectives: We investigated whether such a change can be documented in the IgG response to the major bee venom allergen, phospholipase A2 (PLA2), from patients allergic to bees treated with VIT; whether it is coupled to the shift in IgG subclass distribution (IgG4 predominance) usually observed during VIT; and whether it restores the specificity displayed by IgG antibodies from nonallergic individuals.Methods: Antibody specificity was evaluated in 17 patients allergic to bee venom in competitive ELISAs by using streptavidin biotin technology. Patients were tested before and during specific immunotherapy (at 15 days and 6 months) and compared with another group of 17 patients treated with venom injections for at least 2 years (VIT patients) and 30 healthy individuals.Results: The capacity of individual sera to prevent PLA2 binding of pooled IgG from allergic patients changed rapidly with mean percentage inhibitions falling from 84% ± 14% before starting VIT to 27% ± 13% and 28% ± 7% after 15 days and 6 months of treatment, respectively (p < 0.001 by one-way analysis of variance [ANOVA]). IgG titers were only slightly increased. The capacity of individual sera to prevent the binding of pooled IgG from patients receiving VIT changed rapidly with mean percentage inhibition increasing from 60% ± 12% before starting VIT to 85% ± 6% and 82% ± 6% after 15 days and 6 months of treatment, respectively (p < 0.001 by one-way ANOVA). Similar results were found regardless of whether pooled IgG1 or pooled IgG4 were used.Conclusion: VIT results in a rapid change in the antigenic reactivity of anti-PLA2 IgG antibody of human allergic sera, restoring, although not completely, the specificity peculiar to IgG from healthy individuals. This suggests that allergic status and immunoprotection correlate with the preferential expression of distinct IgG specificities, which appear equally distributed over the IgG1 and IgG4 antibody subclasses. It is, however, not known whether the shift in IgG specificity is one of the operative mechanisms of VIT. (J Allergy Clin Immunol 1998;102:118-26.)" @default.
• W2094941393 created "2016-06-24" @default.
• W2094941393 creator A5008959361 @default.
• W2094941393 creator A5022431389 @default.
• W2094941393 creator A5023442812 @default.
• W2094941393 creator A5031207152 @default.
• W2094941393 creator A5033302467 @default.
• W2094941393 creator A5036601889 @default.
• W2094941393 date "1998-07-01" @default.
• W2094941393 modified "2023-10-11" @default.
• W2094941393 title "Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to subclass expression" @default.
• W2094941393 cites W1511573895 @default.
• W2094941393 cites W1518596541 @default.
• W2094941393 cites W1583886451 @default.
• W2094941393 cites W1882915604 @default.
• W2094941393 cites W1892281418 @default.
• W2094941393 cites W1923951093 @default.
• W2094941393 cites W1974694046 @default.
• W2094941393 cites W1977846299 @default.
• W2094941393 cites W1978601707 @default.
• W2094941393 cites W1990812737 @default.
• W2094941393 cites W1991572244 @default.
• W2094941393 cites W2001190723 @default.
• W2094941393 cites W2002722748 @default.
• W2094941393 cites W2012785799 @default.
• W2094941393 cites W2014666620 @default.
• W2094941393 cites W2020170582 @default.
• W2094941393 cites W2020533246 @default.
• W2094941393 cites W2025092519 @default.
• W2094941393 cites W2037720352 @default.
• W2094941393 cites W2042715085 @default.
• W2094941393 cites W2043837854 @default.
• W2094941393 cites W2046242602 @default.
• W2094941393 cites W2048405383 @default.
• W2094941393 cites W2049317479 @default.
• W2094941393 cites W2049669911 @default.
• W2094941393 cites W2056851955 @default.
• W2094941393 cites W2063269760 @default.
• W2094941393 cites W2069281639 @default.
• W2094941393 cites W2069362757 @default.
• W2094941393 cites W2077806468 @default.
• W2094941393 cites W2087170053 @default.
• W2094941393 cites W2088464284 @default.
• W2094941393 cites W2105086836 @default.
• W2094941393 cites W2109513874 @default.
• W2094941393 cites W2141362092 @default.
• W2094941393 cites W2158860741 @default.
• W2094941393 cites W2164025040 @default.
• W2094941393 cites W2615977127 @default.
• W2094941393 doi "https://doi.org/10.1016/s0091-6749(98)70062-4" @default.
• W2094941393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9679855" @default.
• W2094941393 hasPublicationYear "1998" @default.
• W2094941393 type Work @default.
• W2094941393 sameAs 2094941393 @default.
• W2094941393 citedByCount "22" @default.
• W2094941393 countsByYear W20949413932012 @default.
• W2094941393 countsByYear W20949413932015 @default.
• W2094941393 countsByYear W20949413932016 @default.
• W2094941393 countsByYear W20949413932020 @default.
• W2094941393 crossrefType "journal-article" @default.
• W2094941393 hasAuthorship W2094941393A5008959361 @default.
• W2094941393 hasAuthorship W2094941393A5022431389 @default.
• W2094941393 hasAuthorship W2094941393A5023442812 @default.
• W2094941393 hasAuthorship W2094941393A5031207152 @default.
• W2094941393 hasAuthorship W2094941393A5033302467 @default.
• W2094941393 hasAuthorship W2094941393A5036601889 @default.
• W2094941393 hasConcept C159654299 @default.
• W2094941393 hasConcept C18903297 @default.
• W2094941393 hasConcept C203014093 @default.
• W2094941393 hasConcept C207480886 @default.
• W2094941393 hasConcept C2776194381 @default.
• W2094941393 hasConcept C2777701055 @default.
• W2094941393 hasConcept C2779448229 @default.
• W2094941393 hasConcept C2780510475 @default.
• W2094941393 hasConcept C32611913 @default.
• W2094941393 hasConcept C71924100 @default.
• W2094941393 hasConcept C86803240 @default.
• W2094941393 hasConcept C8891405 @default.
• W2094941393 hasConceptScore W2094941393C159654299 @default.
• W2094941393 hasConceptScore W2094941393C18903297 @default.
• W2094941393 hasConceptScore W2094941393C203014093 @default.
• W2094941393 hasConceptScore W2094941393C207480886 @default.
• W2094941393 hasConceptScore W2094941393C2776194381 @default.
• W2094941393 hasConceptScore W2094941393C2777701055 @default.
• W2094941393 hasConceptScore W2094941393C2779448229 @default.
• W2094941393 hasConceptScore W2094941393C2780510475 @default.
• W2094941393 hasConceptScore W2094941393C32611913 @default.
• W2094941393 hasConceptScore W2094941393C71924100 @default.
• W2094941393 hasConceptScore W2094941393C86803240 @default.
• W2094941393 hasConceptScore W2094941393C8891405 @default.
• W2094941393 hasIssue "1" @default.
• W2094941393 hasLocation W20949413931 @default.
• W2094941393 hasLocation W20949413932 @default.
• W2094941393 hasOpenAccess W2094941393 @default.
• W2094941393 hasPrimaryLocation W20949413931 @default.
• W2094941393 hasRelatedWork W1511067427 @default.
• W2094941393 hasRelatedWork W1549155385 @default.
• W2094941393 hasRelatedWork W2009011029 @default.

• next