FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094949569> ?p ?o ?g. }

• W2094949569 endingPage "202" @default.
• W2094949569 startingPage "195" @default.
• W2094949569 abstract "Oxidative stress has been considered to be a major cause of cellular injuries in a variety of chronic health problems, such as carcinogenesis and neurodegenerative disorders. The brain appears to be more susceptible to oxidative damage than other organs. Therefore, the existence of antioxidants may be essential in brain protective systems. The antioxidative and free radical scavenging effects of endomorphin 1 (EM1) and endomorphin 2 (EM2), endogenous opioid peptides in the brain, have been investigated in vitro. The oxidative damage was initiated by a water-soluble initiator 2,2′-azobis(2-amidinopropane hydrocholoride) (AAPH) and hydrogen peroxide (H 2 O 2 ). The linoleic acid peroxidation, DNA and protein damage were monitored by formation of hydroperoxides, by plasmid pBR 322 DNA nicking assay and single-cell alkaline electrophoresis, and by SDS-polyacrylamide gel electrophoresis. Endomorphins can inhibit lipid peroxidation, DNA strand breakage, and protein fragmentation induced by free radical. Endomorphins also reacted with galvinoxyl radicals in homogeneous solution, and the pseudo-first-order rate constants were determined spectrophotometrically by following the disappearance of galvinoxyl radicals. In all assay systems, EM1 was more potent than EM2 and GSH, a major intracellular water-soluble antioxidant. We propose that endomorphins are one of the protective systems against free radical-induced damage in the brain." @default.
• W2094949569 created "2016-06-24" @default.
• W2094949569 creator A5005660470 @default.
• W2094949569 creator A5049585978 @default.
• W2094949569 creator A5061521733 @default.
• W2094949569 creator A5066707494 @default.
• W2094949569 creator A5070812231 @default.
• W2094949569 creator A5073212256 @default.
• W2094949569 creator A5082062856 @default.
• W2094949569 date "2003-11-01" @default.
• W2094949569 modified "2023-09-27" @default.
• W2094949569 title "Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage" @default.
• W2094949569 cites W1522890520 @default.
• W2094949569 cites W1786911182 @default.
• W2094949569 cites W1965494788 @default.
• W2094949569 cites W1970661834 @default.
• W2094949569 cites W1971004115 @default.
• W2094949569 cites W1971731173 @default.
• W2094949569 cites W1974985599 @default.
• W2094949569 cites W1975262853 @default.
• W2094949569 cites W1975884605 @default.
• W2094949569 cites W1982870743 @default.
• W2094949569 cites W1988474281 @default.
• W2094949569 cites W1989995853 @default.
• W2094949569 cites W1991814119 @default.
• W2094949569 cites W1993867714 @default.
• W2094949569 cites W2000060136 @default.
• W2094949569 cites W2007663048 @default.
• W2094949569 cites W2009760868 @default.
• W2094949569 cites W2010748171 @default.
• W2094949569 cites W2011719985 @default.
• W2094949569 cites W2013021190 @default.
• W2094949569 cites W2019348883 @default.
• W2094949569 cites W2029857257 @default.
• W2094949569 cites W2030020662 @default.
• W2094949569 cites W2039518578 @default.
• W2094949569 cites W2043353183 @default.
• W2094949569 cites W2046181541 @default.
• W2094949569 cites W2050814430 @default.
• W2094949569 cites W2054402386 @default.
• W2094949569 cites W2056540017 @default.
• W2094949569 cites W2059015164 @default.
• W2094949569 cites W2061553681 @default.
• W2094949569 cites W2070046033 @default.
• W2094949569 cites W2073147936 @default.
• W2094949569 cites W2081569286 @default.
• W2094949569 cites W2082296321 @default.
• W2094949569 cites W2092629964 @default.
• W2094949569 cites W2094337876 @default.
• W2094949569 cites W2110223248 @default.
• W2094949569 cites W2132534755 @default.
• W2094949569 cites W2155645216 @default.
• W2094949569 cites W2163736612 @default.
• W2094949569 cites W2167994763 @default.
• W2094949569 doi "https://doi.org/10.1016/j.bbadis.2003.09.007" @default.
• W2094949569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14636951" @default.
• W2094949569 hasPublicationYear "2003" @default.
• W2094949569 type Work @default.
• W2094949569 sameAs 2094949569 @default.
• W2094949569 citedByCount "29" @default.
• W2094949569 countsByYear W20949495692013 @default.
• W2094949569 countsByYear W20949495692014 @default.
• W2094949569 countsByYear W20949495692016 @default.
• W2094949569 countsByYear W20949495692017 @default.
• W2094949569 countsByYear W20949495692018 @default.
• W2094949569 countsByYear W20949495692021 @default.
• W2094949569 countsByYear W20949495692022 @default.
• W2094949569 crossrefType "journal-article" @default.
• W2094949569 hasAuthorship W2094949569A5005660470 @default.
• W2094949569 hasAuthorship W2094949569A5049585978 @default.
• W2094949569 hasAuthorship W2094949569A5061521733 @default.
• W2094949569 hasAuthorship W2094949569A5066707494 @default.
• W2094949569 hasAuthorship W2094949569A5070812231 @default.
• W2094949569 hasAuthorship W2094949569A5073212256 @default.
• W2094949569 hasAuthorship W2094949569A5082062856 @default.
• W2094949569 hasBestOaLocation W20949495691 @default.
• W2094949569 hasConcept C139066938 @default.
• W2094949569 hasConcept C143425029 @default.
• W2094949569 hasConcept C16613235 @default.
• W2094949569 hasConcept C185592680 @default.
• W2094949569 hasConcept C2776151105 @default.
• W2094949569 hasConcept C2778004101 @default.
• W2094949569 hasConcept C2780829032 @default.
• W2094949569 hasConcept C2781119792 @default.
• W2094949569 hasConcept C533411734 @default.
• W2094949569 hasConcept C552990157 @default.
• W2094949569 hasConcept C55493867 @default.
• W2094949569 hasConcept C86803240 @default.
• W2094949569 hasConcept C98274493 @default.
• W2094949569 hasConceptScore W2094949569C139066938 @default.
• W2094949569 hasConceptScore W2094949569C143425029 @default.
• W2094949569 hasConceptScore W2094949569C16613235 @default.
• W2094949569 hasConceptScore W2094949569C185592680 @default.
• W2094949569 hasConceptScore W2094949569C2776151105 @default.
• W2094949569 hasConceptScore W2094949569C2778004101 @default.
• W2094949569 hasConceptScore W2094949569C2780829032 @default.
• W2094949569 hasConceptScore W2094949569C2781119792 @default.
• W2094949569 hasConceptScore W2094949569C533411734 @default.

• next