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- W2094954676 endingPage "B125" @default.
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- W2094954676 abstract "Killing of Neisseria meningitidis can result from complement-mediated serum bactericidal activity (SBA) or opsonophagocytosis (OPA), or a combination of the two mechanisms. While SBA titers > or =1:4 confer protection, recent evidence suggests that this threshold titer may not be required. For example, the incidence of meningococcal disease declines between ages 1 and 4 years without evidence of acquisition of SBA titers > or =1:4. Meningococcal polysaccharide vaccination also elicited OPA and lowered the risk of disease in patients with late complement component deficiencies whose sera did not support SBA. Sera from healthy adults immunized with an outer membrane vesicle vaccine showed OPA killing of N. meningitidis with C6-depleted complement, and whole blood from complement-sufficient non-immunized adults with SBA titers <1:4 also frequently had killing activity. Collectively the data indicate that SBA titers <1:4 and/or vaccine-induced OPA can confer protection against meningococcal disease." @default.
- W2094954676 created "2016-06-24" @default.
- W2094954676 creator A5006315819 @default.
- W2094954676 date "2009-06-01" @default.
- W2094954676 modified "2023-10-12" @default.
- W2094954676 title "Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease" @default.
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- W2094954676 doi "https://doi.org/10.1016/j.vaccine.2009.04.066" @default.
- W2094954676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2751589" @default.
- W2094954676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19477054" @default.
- W2094954676 hasPublicationYear "2009" @default.
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