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- W2094962008 abstract "An enantioselective Diels−Alder reaction catalyzed by an Evans' copper−bis(oxazoline) complex was utilized to construct a highly functionalized spirolactam, a key intermediate in our projected total synthesis of the marine toxin, gymnodimine. Additional transformations, including a mild N-tosyl group deprotection, afforded a keto spirocyclic imine moiety, the proposed pharmacophore of gymnodimine. Thus, the prepared ketone is a potentially useful intermediate for conjugation to provide an immunogen for eventual monitoring of gymnodimine and congeners." @default.
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- W2094962008 date "2005-10-14" @default.
- W2094962008 modified "2023-10-10" @default.
- W2094962008 title "Studies toward a Marine Toxin Immunogen: Enantioselective Synthesis of the Spirocyclic Imine of (−)-Gymnodimine" @default.
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- W2094962008 doi "https://doi.org/10.1021/ol051840r" @default.
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