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• W2094984037 abstract "Summary Introduction Previous studies have indicated that a deletion on the short arm of chromosome 1 negatively predicts survival in patients with multiple myeloma ( MM ). Due to the small sample size in each study, we performed this meta‐analysis to comprehensively investigate the association between the 1p deletion and survival in patients with MM . Methods A literature search was conducted in both foreign and C hinese databases, including SinoMed, CNKI, Wanfang, PubMed, EMBASE, and Scopus. Hazard ratios ( HR ) with 95% confidence intervals ( CI ) for overall survival ( OS ) and progression‐free survival ( PFS ) in 11 eligible articles were extracted or calculated to analyze the pooled HR , which was estimated by fixed‐effect or random‐effect models based on the heterogeneity between included articles. A subgroup analysis and a meta‐regression were conducted, and Galbraith plots were generated to examine any possible heterogeneity. Results The HR s for OS were available in nine articles, whereas five articles discussed HR s for PFS . The HR with 95% CI was 1.989 (95% CI 1.522–2.600, P = 0.017, I 2 = 57.1%) when comparing the OS of patients with 1p deletion with the OS of those without this deletion. For PFS , 1p deletion still predicted a poor prognosis ( HR 2.11, 95% CI 1.54–2.88, P = 0.292, I 2 = 19.3%). Moreover, the subgroup analysis suggested that either the deleted gene on 1p or techniques for detecting chromosome abnormalities contributed to the heterogeneity, which was partially consistent with the results derived from a meta‐regression analysis and the Galbraith plot method. Conclusion Our meta‐analysis provides globally quantifiable confirmation of the adverse prognostic role of 1p deletion in OS and PFS for patients with MM ." @default.
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• W2094984037 date "2014-01-27" @default.
• W2094984037 modified "2023-10-04" @default.
• W2094984037 title "Prognostic value of 1p deletion for multiple myeloma: a meta‐analysis" @default.
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• W2094984037 doi "https://doi.org/10.1111/ijlh.12189" @default.
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