Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094992050> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2094992050 endingPage "54" @default.
- W2094992050 startingPage "43" @default.
- W2094992050 abstract "Recent advances in pulmonary regenerative medicine have increased the demand for alveolar epithelial progenitor cells. Fetal lung tissues from spontaneous pregnancy losses may represent a neglected, yet ethically and societally acceptable source of alveolar epithelial cells. The aim of this study was to determine the regenerative capacity of fetal lungs obtained from second trimester stillbirths. Lung tissues were harvested from 11 stillborn fetuses (13 to 22 weeks' gestation) at postdelivery intervals ranging from 10 to 41 hours and grafted to the renal subcapsular space of immune-suppressed rats to provide optimal growth conditions. Histology, epithelial and alveolar type II cell proliferation, and surfactant protein-C mRNA expression were studied in preimplantation lung tissues and in xenografts at posttransplantation week 2. All xenografts displayed advanced architectural maturation compared with their respective preimplantation tissues, regardless of gestational age and postdelivery interval. The proliferative activity of the grafts was significantly higher than that of the preimplantation tissues (mean Ki-67 labeling index 26.7%±7.7% versus 14.7%±10.5%; P<.01). The proliferative activity of grafts obtained after a long (>36 hours) postdelivery interval was significantly higher than that of the corresponding preimplantation tissue, and equivalent to that of grafts obtained after a short postdelivery interval (<14 hours). The regenerative capacity of fetal lung tissue was greater at younger (13 to 17 weeks) than at older (19 to 22 weeks) gestational ages. The presence of inflammation/chorioamnionitis did not appear to affect graft regeneration. All grafts studied displayed robust surfactant protein-C mRNA expression. In conclusion, fetal lung tissues from second trimester stillbirths can regain their inherent high regenerative potential following short-term culture, even if harvested more than 36 hours after delivery." @default.
- W2094992050 created "2016-06-24" @default.
- W2094992050 creator A5011764402 @default.
- W2094992050 creator A5043505435 @default.
- W2094992050 creator A5062185541 @default.
- W2094992050 creator A5083475413 @default.
- W2094992050 creator A5088446802 @default.
- W2094992050 date "2011-12-14" @default.
- W2094992050 modified "2023-10-05" @default.
- W2094992050 title "Resilience of the human fetal lung following stillbirth: Potential relevance for pulmonary regenerative medicine" @default.
- W2094992050 cites W1966230298 @default.
- W2094992050 cites W1978957262 @default.
- W2094992050 cites W2018599317 @default.
- W2094992050 cites W2041073759 @default.
- W2094992050 cites W2054288412 @default.
- W2094992050 cites W2071337295 @default.
- W2094992050 cites W2085393707 @default.
- W2094992050 cites W2087709036 @default.
- W2094992050 cites W2107277218 @default.
- W2094992050 cites W2107291281 @default.
- W2094992050 cites W2111791413 @default.
- W2094992050 cites W2127452986 @default.
- W2094992050 cites W2141535683 @default.
- W2094992050 cites W2147156629 @default.
- W2094992050 cites W2162219673 @default.
- W2094992050 cites W2165871414 @default.
- W2094992050 cites W2325291382 @default.
- W2094992050 cites W4247736539 @default.
- W2094992050 doi "https://doi.org/10.3109/01902148.2011.641139" @default.
- W2094992050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3677542" @default.
- W2094992050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22168578" @default.
- W2094992050 hasPublicationYear "2011" @default.
- W2094992050 type Work @default.
- W2094992050 sameAs 2094992050 @default.
- W2094992050 citedByCount "7" @default.
- W2094992050 countsByYear W20949920502013 @default.
- W2094992050 countsByYear W20949920502014 @default.
- W2094992050 countsByYear W20949920502015 @default.
- W2094992050 countsByYear W20949920502022 @default.
- W2094992050 crossrefType "journal-article" @default.
- W2094992050 hasAuthorship W2094992050A5011764402 @default.
- W2094992050 hasAuthorship W2094992050A5043505435 @default.
- W2094992050 hasAuthorship W2094992050A5062185541 @default.
- W2094992050 hasAuthorship W2094992050A5083475413 @default.
- W2094992050 hasAuthorship W2094992050A5088446802 @default.
- W2094992050 hasBestOaLocation W20949920502 @default.
- W2094992050 hasConcept C126322002 @default.
- W2094992050 hasConcept C142724271 @default.
- W2094992050 hasConcept C16685009 @default.
- W2094992050 hasConcept C171056886 @default.
- W2094992050 hasConcept C172680121 @default.
- W2094992050 hasConcept C2777714996 @default.
- W2094992050 hasConcept C2778376644 @default.
- W2094992050 hasConcept C2779234561 @default.
- W2094992050 hasConcept C46973012 @default.
- W2094992050 hasConcept C54355233 @default.
- W2094992050 hasConcept C71924100 @default.
- W2094992050 hasConcept C86803240 @default.
- W2094992050 hasConcept C95444343 @default.
- W2094992050 hasConceptScore W2094992050C126322002 @default.
- W2094992050 hasConceptScore W2094992050C142724271 @default.
- W2094992050 hasConceptScore W2094992050C16685009 @default.
- W2094992050 hasConceptScore W2094992050C171056886 @default.
- W2094992050 hasConceptScore W2094992050C172680121 @default.
- W2094992050 hasConceptScore W2094992050C2777714996 @default.
- W2094992050 hasConceptScore W2094992050C2778376644 @default.
- W2094992050 hasConceptScore W2094992050C2779234561 @default.
- W2094992050 hasConceptScore W2094992050C46973012 @default.
- W2094992050 hasConceptScore W2094992050C54355233 @default.
- W2094992050 hasConceptScore W2094992050C71924100 @default.
- W2094992050 hasConceptScore W2094992050C86803240 @default.
- W2094992050 hasConceptScore W2094992050C95444343 @default.
- W2094992050 hasIssue "1" @default.
- W2094992050 hasLocation W20949920501 @default.
- W2094992050 hasLocation W20949920502 @default.
- W2094992050 hasLocation W20949920503 @default.
- W2094992050 hasLocation W20949920504 @default.
- W2094992050 hasOpenAccess W2094992050 @default.
- W2094992050 hasPrimaryLocation W20949920501 @default.
- W2094992050 hasRelatedWork W1592788815 @default.
- W2094992050 hasRelatedWork W1962551321 @default.
- W2094992050 hasRelatedWork W2013828790 @default.
- W2094992050 hasRelatedWork W2034531855 @default.
- W2094992050 hasRelatedWork W2048583782 @default.
- W2094992050 hasRelatedWork W2069419762 @default.
- W2094992050 hasRelatedWork W2163638983 @default.
- W2094992050 hasRelatedWork W2280325471 @default.
- W2094992050 hasRelatedWork W2400331667 @default.
- W2094992050 hasRelatedWork W2964727434 @default.
- W2094992050 hasVolume "38" @default.
- W2094992050 isParatext "false" @default.
- W2094992050 isRetracted "false" @default.
- W2094992050 magId "2094992050" @default.
- W2094992050 workType "article" @default.