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- W2094995306 abstract "The serum levels of matrix metalloproteinase-9 (MMP-9) in neuropsychiatric disorders of adults have been widely investigated. So far, no studies have been conducted on the relationship of MMP-9 and cognitive domains in children with two phenotype models, attention deficit/hyperactivity disorder and hyperkinetic disorder (ADHD/HKD). The aim of this research was to evaluate and test the hypothesis that serum MMP-9 levels are associated with the severity of symptoms in children with ADHD/HKD and to compare the results in two models of this disorder. The study group comprised 37 Caucasian boys aged 7–12 years with HKD, being a subset of the combined ADHD subtype. Intellectual functions were measured using Wechsler Intelligence Scale for Children-Revised. The analysis of serum concentrations of MMP-9 was based on a quantitative sandwich ELISA. The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD (β = 0.33; p = 0.043) and HKD (β = 0.34, p = 0.037) model. According to the results, elevated levels of serum MMP-9 in boys with HKD may be associated with clinical impulsivity domain (β = 0.38; p = 0.019)." @default.
- W2094995306 created "2016-06-24" @default.
- W2094995306 creator A5020480934 @default.
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- W2094995306 creator A5037510184 @default.
- W2094995306 creator A5048321103 @default.
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- W2094995306 date "2014-03-17" @default.
- W2094995306 modified "2023-09-25" @default.
- W2094995306 title "Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD" @default.
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- W2094995306 doi "https://doi.org/10.1007/s00787-014-0533-z" @default.
- W2094995306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4291510" @default.
- W2094995306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24633733" @default.
- W2094995306 hasPublicationYear "2014" @default.
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