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- W2094996847 abstract "A method for the design and statistical evaluation of haemagglutination inhibition tests is presented. Erythrocyte settling patterns obtained with antigen dilution series are read against a series of pictures of such patterns. To each pattern a score is assigned. The same dilution factor is used throughout an experiment, so that antigen concentrations can be transformed into simple dilution numbers. The response metameter, defined per series, is the critical dilution number, i.e. the dilution number for which the progressive sum of three scores equals a chosen critical value. This critical dilution number is found by linear interpolation. Potency ratios between antigen preparations are obtained from the differences between their critical dilution numbers. For higher precision experiments are arranged at least in blocks. In order to ensure the independence of observations as required for the statistical analysis the series - not the tubes - are randomised. The procedure was applied to human chorionic gonadotrophin (HCG). In some experiments of the split-plot type the effect of the test reagents on the potency ratios of antigen preparations was investigated. No reagent effect was found when HCG preparations were assayed with an HCG haemagglutination inhibition test against an HCG standard. The statistically designed haemagglutination inhibution assay is very useful for determining potencies of hormone preparations. The high precision and the possibility of calculating confidence intervals are important when e.g. yields and specific activities have to be compared. The efficiency is very high, especially when many unknowns and an appropriate number of standard series are accommodated in one assay." @default.
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- W2094996847 title "Statistically designed haemagglutination inhibition tests" @default.
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- W2094996847 doi "https://doi.org/10.1016/0022-1759(72)90040-3" @default.
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